[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100550531":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":112,"centralContacts":117,"locations":124,"responsibleParty":141,"collaborators":122,"id":143,"slug":122,"hasResults":144,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":122,"eligibilityCriteria":148,"healthyVolunteers":144,"sex":149,"minAge":150,"maxAge":122,"enrollmentInfo":151,"targetDuration":122,"studyType":154,"phases":155,"briefSummary":157,"conditions":158,"keywords":122,"overallStatus":160,"whyStopped":122,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":170},{"fullName":5,"class":6},"Jonsson Comprehensive Cancer Center","OTHER",[8,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Group I (standard of care surgical resection)","ACTIVE_COMPARATOR","Patients undergo surgical resection with standard intraoperative guidance using contrast-enhanced MRI. Patients also undergo post operative standard of care radiation therapy over 30 fractions and receive standard of care temozolomide PO for 6 weeks. Additionally, patients undergo MRI during follow up.",[13,14,15,16,17],"Procedure: Contrast-enhanced Magnetic Resonance Imaging","Procedure: Magnetic Resonance Imaging","Radiation: Radiation Therapy","Procedure: Surgical Procedure","Drug: Temozolomide",{"label":19,"type":20,"description":21,"interventionNames":22},"Group II (CEST MRI based surgical resection)","EXPERIMENTAL","Patients undergo surgical resection with intraoperative guidance using CEST MRI. Patients also undergo post operative standard of care radiation therapy over 30 fractions and receive standard of care temozolomide PO for 6 weeks. Additionally, patients undergo MRI during follow up.",[23,14,15,16,17],"Procedure: Chemical Exchange Saturation Transfer Magnetic Resonance Imaging",[25,32,40,60,78,92],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"PROCEDURE","Chemical Exchange Saturation Transfer Magnetic Resonance Imaging","Undergo CEST MRI",[19],[31],"Chemical Exchange Saturation Transfer MRI",{"type":26,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Contrast-enhanced Magnetic Resonance Imaging","Undergo contrast-enhanced MRI",[9],[37,38,39],"CONTRAST ENHANCED MRI","Contrast-enhanced MRI","MRI With Contrast",{"type":26,"name":41,"description":42,"armGroupLabels":43,"otherNames":44},"Magnetic Resonance Imaging","Undergo MRI",[9,19],[45,46,47,48,49,50,51,52,53,54,55,56,57,58,59],"Magnetic Resonance","Magnetic Resonance Imaging (MRI)","Magnetic resonance imaging (procedure)","Magnetic Resonance Imaging Scan","Medical Imaging, Magnetic Resonance \u002F Nuclear Magnetic Resonance","MR","MR Imaging","MRI","MRI Scan","MRIs","NMR Imaging","NMRI","Nuclear Magnetic Resonance Imaging","sMRI","Structural MRI",{"type":61,"name":62,"description":63,"armGroupLabels":64,"otherNames":65},"RADIATION","Radiation Therapy","Undergo standard of care radiation therapy",[9,19],[66,67,68,69,70,71,72,73,74,75,76,77],"Cancer Radiotherapy","Energy Type","ENERGY_TYPE","Irradiate","Irradiated","Irradiation","Radiation","Radiation Therapy, NOS","Radiotherapeutics","Radiotherapy","RT","Therapy, Radiation",{"type":26,"name":79,"description":80,"armGroupLabels":81,"otherNames":82},"Surgical Procedure","Undergo surgical resection",[9,19],[83,84,85,86,87,88,89,90,91],"Operation","Surgery","Surgery Type","Surgery, NOS","Surgical","Surgical Intervention","Surgical Interventions","Surgical Procedures","Type of Surgery",{"type":93,"name":94,"description":95,"armGroupLabels":96,"otherNames":97},"DRUG","Temozolomide","Given PO",[9,19],[98,99,100,101,102,103,104,105,106,107,108,109,110,111],"CCRG-81045","Gliotem","Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-","M & B 39831","M and B 39831","Methazolastone","RP-46161","SCH 52365","Temcad","Temizole","Temodal","Temodar","Temomedac","TMZ",[113],{"name":114,"affiliation":115,"role":116},"Kunal S Patel, MD","UCLA \u002F Jonsson Comprehensive Cancer Center","PRINCIPAL_INVESTIGATOR",[118],{"name":119,"role":120,"phone":121,"phoneExt":122,"email":123},"Kunal Patel, MD","CONTACT","310-825-5111",null,"KunalPatel@mednet.ucla.edu",[125],{"facility":115,"status":122,"city":126,"state":127,"zip":128,"country":129,"cosmosGeoPoint":130,"geoPoint":135,"contacts":136},"Los Angeles","California","90095","United States",{"type":131,"coordinates":132},"Point",[133,134],-118.24368,34.05223,{"lat":134,"lon":133},[137,140],{"name":138,"role":120,"phone":121,"phoneExt":122,"email":139},"Kunal S. Patel","kunalpatel@mednet.ucla.edu",{"name":138,"role":116,"phone":122,"phoneExt":122,"email":122},{"type":142,"investigatorFullName":122,"investigatorTitle":122,"investigatorAffiliation":122,"oldNameTitle":122,"oldOrganization":122},"SPONSOR","100550531",false,"NCT06448286","PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma","PH Weighted Chemical Exchange Saturation Transfer Based Surgical Resections of Glioblastoma","Inclusion Criteria:\n\n* Male or female ≥ 18 years of age\n* Documentation of a newly diagnosed World Health Organization (WHO) grade IV glioblastoma as evidenced by clinical features and imaging data\n* Written informed consent (and assent when applicable) obtained from subject or subject's legal representative and ability for subject to comply with the requirements of the study\n\nExclusion Criteria:\n\n* Male or female \\\u003C 18 years of age\n* Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data\n* Not medically cleared for surgery\n* Previous treatment (any chemotherapy, molecular therapy, immunotherapy, or radiation therapy)","ALL","18 Years",{"count":152,"type":153},60,"ESTIMATED","INTERVENTIONAL",[156],"PHASE3","This phase III trial compares pH weighted chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI)-based surgical resections to standard of care surgical resections for the treatment of patients with glioblastoma. Standard of care therapy for glioblastoma is surgery to remove tumor tissue that enhances on standard MRI imaging, however, it has been shown that significant tumor burden exists in the region around the tumor tissue that does not enhance with standard MRI. MRI is a procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body. These pictures can show the difference between normal and tumor tissue. CEST MRI is a technique that uses differences in the tissue environment, like protein concentration or intracellular pH, to generate contrast differences. CEST MRI may identify tumor tissue that does not enhance with standard of care MRI. PH weighted CEST MRI based surgical resection may be more effective compared to standard of care surgical resection in treating patients with glioblastoma.",[159],"Glioblastoma","NOT_YET_RECRUITING","2026-06-11",{"date":163,"type":164},"2026-06-15","ACTUAL",{"date":166,"type":153},"2026-12-01",{"date":168,"type":153},"2030-06-01",{"name":5,"class":6},1]