[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616911":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":257,"collaborators":260,"id":285,"slug":26,"hasResults":286,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":26,"eligibilityCriteria":290,"healthyVolunteers":286,"sex":291,"minAge":292,"maxAge":293,"enrollmentInfo":294,"targetDuration":26,"studyType":297,"phases":298,"briefSummary":300,"conditions":301,"keywords":304,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":315},{"fullName":5,"class":6},"Sun Yat-sen University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Houyanqing Oral Liquid combined with Conventional Treatment","EXPERIMENTAL","This arm involves Houyanqing Oral Liquid combined with conventional treatment for preventing radiation-induced oral mucositis (RIOM) in nasopharyngeal carcinoma patients receiving radical radiotherapy. Specific interventions include: 1) Houyanqing Oral Liquid administration before and during radiotherapy; 2) Conventional treatment (same as the control arm): oral hygiene management, epithelial repair promotion, and symptomatic support therapy; 3) Radical radiotherapy (conventional fractionation). The aim is to evaluate the effect of this combined regimen on reducing RIOM severity.",[13,14],"Drug: Houyanqing Oral Liquid","Other: Conventional Treatment for Radiation-Induced Oral Mucositis",{"label":16,"type":17,"description":18,"interventionNames":19},"Conventional Treatment","ACTIVE_COMPARATOR","This arm consists of conventional treatment for preventing radiation-induced oral mucositis (RIOM) in nasopharyngeal carcinoma patients undergoing radical radiotherapy. Specific interventions include: 1) Oral hygiene management; 2) Epithelial repair promotion; 3) Symptomatic support . Patients in this arm will receive radical radiotherapy (conventional fractionation) but will not be administered Houyanqing Oral Liquid.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Houyanqing Oral Liquid","Houyanqing Oral Liquid is a Chinese herbal preparation formulated with Achyranthes aspera L., Kalimeris indica (L.) Sch.-Bip., Plantago asiatica L., and Carpesium abrotanoides L.. For this study, it is used in nasopharyngeal carcinoma patients receiving radical radiotherapy: the dosage is 10mL per administration, 4 times daily. The medication is initiated prior to radiotherapy and continued until the completion of radiotherapy, with the purpose of preventing and treating radiation-induced oral mucositis.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Conventional Treatment for Radiation-Induced Oral Mucositis","This intervention refers to the conventional management measures for radiation-induced oral mucositis (RIOM) in nasopharyngeal carcinoma patients undergoing radical radiotherapy, including three modules: 1) Oral hygiene management; 2) Epithelial repair promotion; 3) Symptomatic support. These measures are implemented throughout the radiotherapy period to alleviate RIOM-related symptoms.",[16,9],[32],{"name":33,"affiliation":34,"role":35},"Ming-Yuan Chen, MD, PhD","Fifth Affiliated Hospital of Sun Yat-sen University","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","86-13903052650","chmingy@mail.sysu.edu.cn",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Yan-Rou Xie, MD","86-13751762936","292352606@qq.com",[46,64,78,92,102,115,126,140,153,167,177,191,205,219,233,243],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Cancer Hospital Chinese Academy of Medical Science","RECRUITING","Beijing","Beijing Municipality","100021","China",{"type":54,"coordinates":55},"Point",[56,57],116.39723,39.9075,{"lat":57,"lon":56},[60],{"name":61,"role":38,"phone":62,"phoneExt":26,"email":63},"Jun-Ling Yi, PhD.","+86 13661217998","yijunlin1969@163.com",{"facility":65,"status":48,"city":66,"state":67,"zip":68,"country":52,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Fujian Medical University Cancer Hospital","Fuzhou","Fujian","350014",{"type":54,"coordinates":70},[71,72],119.30611,26.06139,{"lat":72,"lon":71},[75],{"name":76,"role":38,"phone":77,"phoneExt":26,"email":26},"Sufang Qiu","86-13609589163",{"facility":79,"status":48,"city":80,"state":81,"zip":82,"country":52,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Sun Yat-sen University Cancer Center","Guangzhou","Guangdong","510060",{"type":54,"coordinates":84},[85,86],113.25,23.11667,{"lat":86,"lon":85},[89],{"name":90,"role":38,"phone":91,"phoneExt":26,"email":26},"Pei-Yu Huang, MD","86-18928013516",{"facility":93,"status":48,"city":80,"state":81,"zip":94,"country":52,"cosmosGeoPoint":95,"geoPoint":97,"contacts":98},"Affiliated Cancer Hospital & Institute of Guangzhou Medical University","510095",{"type":54,"coordinates":96},[85,86],{"lat":86,"lon":85},[99],{"name":100,"role":38,"phone":101,"phoneExt":26,"email":26},"Bin Qi","86-13580580985",{"facility":103,"status":48,"city":104,"state":81,"zip":105,"country":52,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"Cancer Hospital of Shantou University Medical College","Shantou","515041",{"type":54,"coordinates":107},[108,109],116.67876,23.35489,{"lat":109,"lon":108},[112],{"name":113,"role":38,"phone":114,"phoneExt":26,"email":26},"Kai Chen","86-13005222990",{"facility":34,"status":48,"city":116,"state":81,"zip":117,"country":52,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Zhuhai","519000",{"type":54,"coordinates":119},[120,121],113.56778,22.27694,{"lat":121,"lon":120},[124],{"name":125,"role":38,"phone":39,"phoneExt":26,"email":40},"Ming-Yuan Chen, PhD.",{"facility":127,"status":48,"city":128,"state":129,"zip":130,"country":52,"cosmosGeoPoint":131,"geoPoint":135,"contacts":136},"Cancer Hospital of Guangxi Medical University","Nanning","Guangxi","530021",{"type":54,"coordinates":132},[133,134],108.31667,22.81667,{"lat":134,"lon":133},[137],{"name":138,"role":38,"phone":139,"phoneExt":26,"email":26},"Song Qu","86-13607887386",{"facility":141,"status":48,"city":142,"state":129,"zip":143,"country":52,"cosmosGeoPoint":144,"geoPoint":148,"contacts":149},"Wuzhou Red Cross Hospital","Wuzhou","543002",{"type":54,"coordinates":145},[146,147],111.28848,23.48054,{"lat":147,"lon":146},[150],{"name":151,"role":38,"phone":152,"phoneExt":26,"email":26},"Jin-Hui Liang","86-13878480806",{"facility":154,"status":48,"city":155,"state":156,"zip":157,"country":52,"cosmosGeoPoint":158,"geoPoint":162,"contacts":163},"Xiangya Hospital of Central South University","Changsha","Hunan","410008",{"type":54,"coordinates":159},[160,161],112.97087,28.19874,{"lat":161,"lon":160},[164],{"name":165,"role":38,"phone":166,"phoneExt":26,"email":26},"Yu-Xiang He","86-13786112914",{"facility":168,"status":48,"city":155,"state":156,"zip":169,"country":52,"cosmosGeoPoint":170,"geoPoint":172,"contacts":173},"Hunan Cancer Hospital","410013",{"type":54,"coordinates":171},[160,161],{"lat":161,"lon":160},[174],{"name":175,"role":38,"phone":176,"phoneExt":26,"email":26},"Ya-Qian Han","86-18673176667",{"facility":178,"status":48,"city":179,"state":180,"zip":181,"country":52,"cosmosGeoPoint":182,"geoPoint":186,"contacts":187},"The First People's Hospital of Changzhou","Changzhou","Jiangsu","213003",{"type":54,"coordinates":183},[184,185],119.95401,31.77359,{"lat":185,"lon":184},[188],{"name":189,"role":38,"phone":190,"phoneExt":26,"email":26},"Wen-Dong Gu","86-13861220022",{"facility":192,"status":48,"city":193,"state":194,"zip":195,"country":52,"cosmosGeoPoint":196,"geoPoint":200,"contacts":201},"Eye & ENT Hospital of Fudan University","Shanghai","Shanghai Municipality","200031",{"type":54,"coordinates":197},[198,199],121.45806,31.22222,{"lat":199,"lon":198},[202],{"name":203,"role":38,"phone":204,"phoneExt":26,"email":26},"Xiao-Shen Wang","86-18917785187",{"facility":206,"status":48,"city":207,"state":208,"zip":209,"country":52,"cosmosGeoPoint":210,"geoPoint":214,"contacts":215},"West China Hospital of Sichuan University","Chengdu","Sichuan","610041",{"type":54,"coordinates":211},[212,213],104.06667,30.66667,{"lat":213,"lon":212},[216],{"name":217,"role":38,"phone":218,"phoneExt":26,"email":26},"Lei Liu","86-18980606231",{"facility":220,"status":48,"city":221,"state":222,"zip":223,"country":52,"cosmosGeoPoint":224,"geoPoint":228,"contacts":229},"The First Affiliated Hospital of Kunming Medical University","Kunming","Yunnan","650032",{"type":54,"coordinates":225},[226,227],102.71833,25.03889,{"lat":227,"lon":226},[230],{"name":231,"role":38,"phone":232,"phoneExt":26,"email":26},"Zhi-Qiang Wang","86-15887085161",{"facility":234,"status":48,"city":221,"state":222,"zip":235,"country":52,"cosmosGeoPoint":236,"geoPoint":238,"contacts":239},"Yunnan Cancer Hospital","650118",{"type":54,"coordinates":237},[226,227],{"lat":227,"lon":226},[240],{"name":241,"role":38,"phone":242,"phoneExt":26,"email":26},"Ji-Yong Qin","86-13808757779",{"facility":244,"status":48,"city":245,"state":246,"zip":247,"country":52,"cosmosGeoPoint":248,"geoPoint":252,"contacts":253},"Zhejiang Cancer Hospital","Hangzhou","Zhengjiang","310022",{"type":54,"coordinates":249},[250,251],120.16142,30.29365,{"lat":251,"lon":250},[254],{"name":255,"role":38,"phone":256,"phoneExt":26,"email":26},"Feng Jiang","86-13858065192",{"type":35,"investigatorFullName":258,"investigatorTitle":259,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Ming-Yuan Chen","Professor",[261,264,265,266,268,269,271,272,273,275,276,277,278,279,281,283],{"name":262,"class":263},"Fujian Cancer Hospital","OTHER_GOV",{"name":192,"class":6},{"name":244,"class":6},{"name":267,"class":6},"West China Hospital",{"name":234,"class":6},{"name":270,"class":6},"First Affiliated Hospital of Kunming Medical University",{"name":178,"class":6},{"name":154,"class":6},{"name":274,"class":6},"Affiliated Cancer Hospital of Shantou University Medical College",{"name":141,"class":6},{"name":168,"class":6},{"name":127,"class":6},{"name":93,"class":6},{"name":280,"class":6},"Sun Yat-Sen University Cancer Center",{"name":47,"class":282},"UNKNOWN",{"name":284,"class":282},"The Fifth Affiliated Hospital, Sun Yat-sen University","100616911",false,"NCT07311772","Prevention and Treatment of Radiation-Induced Oral Mucositis in NPC With Houyanqing Oral Liquid","A Randomized Controlled Study of Houyanqing Oral Liquid Combined With Conventional Treatment Versus Conventional Treatment Alone for Preventing and Treating Radiation-Induced Oral Mucositis in Nasopharyngeal Carcinoma","Inclusion Criteria:\n\n1. Staged as Stage I-IV according to the 9th edition of the TNM Classification of Malignant Tumors formulated by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC);\n2. Age: 18 to 75 years old;\n3. Karnofsky Performance Status (KPS) score ≥ 80 before treatment;\n4. No oral diseases (such as oral mucositis or salivary gland damage) before radiotherapy;\n5. Requiring radical radiotherapy;\n6. The patient has signed the informed consent form and is willing and able to comply with the study's follow-up visits, treatment plan, laboratory tests, and other research procedures.\n\nExclusion Criteria:\n\n1. Patients with confirmed tumor recurrence, distant tumor metastasis, or who have received other anti-tumor treatments;\n2. Previous history of head and neck radiotherapy;\n3. Known allergy to the drugs used in this study (Houyanqing Oral Liquid, any conventional treatment drugs);\n4. Local use of Houyanqing Oral Liquid, Recombinant Human Epidermal Growth Factor (rhEGF) Topical Solution, Vitamin B12 Solution, or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) mouthwash in the oral cavity within one month before enrollment;\n5. Comorbidities requiring long-term treatment with immunosuppressive drugs, or systemic\u002Flocal use of corticosteroids at immunosuppressive doses before enrollment;\n6. HIV-positive patients;\n7. Pregnant women or lactating women;\n8. Patients with severe mental illnesses;\n9. Patients with severe cardio-cerebrovascular diseases, endocrine disorders, infectious diseases, or other tumors.","ALL","18 Years","75 Years",{"count":295,"type":296},386,"ESTIMATED","INTERVENTIONAL",[299],"PHASE3","To explore the efficacy of Houyanqing Oral Liquid combined with conventional treatment in preventing and treating radiation-induced oral mucositis, so as to improve the quality of life of nasopharyngeal carcinoma patients received radiotherapy.",[302,303],"Nasopharyngeal Cancinoma (NPC)","Radiation-induced Oral Mucositis",[305,303,23],"Nasopharyngeal Cancinoma","2026-05-06",{"date":308,"type":309},"2026-05-07","ACTUAL",{"date":311,"type":309},"2025-12-16",{"date":313,"type":296},"2027-08-15",{"name":5,"class":6},16]