Health Trials

About this trial

The purpose of this investigator-initiated randomized control trial is to determine whether oral Nifedipine versus oral Labetalol is superior in controlling high blood pressures in the postpartum period.

Eligibility criteria

Qualifiers

Female

Women who develop postpartum hypertension* after delivery of the placenta or chronic hypertensive postpartum women who require medication for blood pressure control.

Postpartum hypertension requiring treatment are defined as systolic blood pressure greater than or equal to 140mmHg or diastolic blood pressure greater than or equal to 90mmHg on at least 2 occasions at least 4 hours apart, or systolic blood pressure greater than or equal to 160mmHg or diastolic blood pressure greater than 110mmHg sustained for more than 15 minutes.

Disqualifiers

History of moderate persistent asthma, coronary artery disease, heart failure, AV heart block, pulmonary edema

Contraindication to either Nifedipine or Labetalol

HR <60 or >110

Native language other than English or Spanish

Trial design

Treatments tested in this trial

  • Oral Nifedipine
  • Oral Labetalol

Treatment groups

500 Participants
are divided into 2 treatment groups

Locations

1
Loma Linda University Health92350, Loma LindaCalifornia, United States

Sponsors and collaborators

Loma Linda University

Lead sponsor

Source ClinicalTrials.gov