[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633463":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":24,"locations":30,"responsibleParty":45,"collaborators":48,"id":52,"slug":18,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":18,"enrollmentInfo":61,"targetDuration":18,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":18,"overallStatus":74,"whyStopped":18,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Beijing Tiantan Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Stratified blood pressure management group","EXPERIMENTAL","Participants allocated to the intervention arm will be subjected to a stratified blood pressure (BP) management strategy, which is tailored to their pre-procedural pial collateral status as evaluated by the ASITN\u002FSIR collateral grading system.",[13],"Other: Stratified Blood Pressure Management",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","Subjects allocated to the control arm will be managed in accordance with the standard-of-care blood pressure targets recommended by prevailing clinical guidelines.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"Stratified Blood Pressure Management","For participants in the intervention arm whose systolic blood pressure (SBP) exceeds the assigned target post-randomization, antihypertensive therapy must be initiated immediately within the neurology ward or neuro intensive care unit. The SBP should be brought below the designated target within 2 hours and maintained within the assigned range for the subsequent 24 hours (or until hospital discharge or death, whichever occurs first). The BP-lowering process must be smooth and gradual to avoid precipitous drops or severe fluctuations.\n\nThe SBP target is determined by the following criteria:\n\nSafety Constraint: The maximum reduction in SBP must not exceed 20% relative to the baseline BP measured at randomization.\n\nStratified Targets based on Collateral Status: ASITN\u002FSIR Grade 0-2; ASITN\u002FSIR Grade 3-4.",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"Liping Liu","CONTACT","+86-010-59978328","lipingsister@gmail.com",[31],{"facility":32,"status":18,"city":33,"state":34,"zip":35,"country":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Beijing Tiantan Hospital, Capital Medical University","Beijing","Beijing Municipality","100070","China",{"type":38,"coordinates":39},"Point",[40,41],116.39723,39.9075,{"lat":41,"lon":40},[44],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},{"type":46,"investigatorFullName":26,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Professor",[49],{"name":50,"class":51},"Central Hospital of Dalian University of Technology","UNKNOWN","100633463",false,"NCT07527013","Stratified Blood Pressure Management After Endovascular Treatment for Acute Ischemic Stroke","Stratified Blood Pressure Management After Endovascular Treatment for Acute Ischemic Stroke (RESCUE-BP)","RESCUE-BP","Inclusion Criteria:\n\n* Age ≥ 18 years；\n* Clinical diagnosis of acute ischemic stroke caused by anterior circulation large vessel occlusion (internal carotid artery or M1\u002FM2 segment of the middle cerebral artery)；\n* Received EVT (including direct EVT and bridging therapy) within 24 hours of symptom onset；\n* Baseline ASPECTS score ≥ 3；\n* Baseline NIHSS score ≥ 6；\n* Successful recanalization achieved post-procedure (defined as expanded Thrombolysis in Cerebral Infarction \\[eTICI\\] grade ≥ 2b50);\n* Two consecutive systolic blood pressure (SBP) measurements ≥ 150 mmHg within 3 hours post-recanalization (with a measurement interval of no less than 5 minutes)；\n* Able to complete randomization within 3 hours post-recanalization；\n* Informed consent signed by the patient or their legal representative.\n\nExclusion Criteria:\n\n* Pre-stroke mRS score \\> 1；\n* Comatose state (Glasgow Coma Scale \\[GCS\\] score \\\u003C 8);\n* Symptomatic intracerebral hemorrhage occurred before randomization;\n* Within the past 3 months, occurrence of acute ST-segment elevation myocardial infarction (MI), acute decompensated heart failure, QTc \\> 500 ms, hospitalization or involuntary coronary intervention due to acute coronary syndrome, MI, or cardiac arrest; or heart failure (New York Heart Association \\[NYHA\\] class III\u002FIV or left ventricular ejection fraction \\\u003C 35%); or known history of ventricular tachycardia;\n* History of severe renal insufficiency, acute renal failure, dialysis, or estimated glomerular filtration rate (eGFR) \\\u003C 20 ml\u002Fmin\u002F1.72m²;\n* History of severe hepatic disease, or Aspartate Aminotransferase (AST) and\u002For Alanine Aminotransferase (ALT) and\u002For Gamma-Glutamyl Transferase (GGT) ≥ 3×ULN and\u002For Total Bilirubin (TBIL) ≥ 2×ULN;\n* Aortic dissection, cervical artery dissection, or cerebral artery dissection; unruptured aortic aneurysm or cerebral aneurysm; or known arteriovenous malformation;\n* Comorbidities with a life expectancy \\\u003C 6 months (e.g., malignant tumors);\n* Pregnant or lactating women;\n* Participation in another clinical trial within the past 30 days;\n* Any clinical condition judged by the research team that might limit compliance with study procedures.","ALL","18 Years",{"count":62,"type":63},544,"ESTIMATED","INTERVENTIONAL",[66],"PHASE3","The RESCUE-BP is a multi-centered, prospective, randomized, open label, blinded endpoint (PROBE) phase III trial. In patients with acute ischemic stroke who have undergone endovascular treatment and achieved successful recanalization, the evaluation will compare a stratified blood pressure management strategy based on the collateral circulation status with the guideline-recommended conventional blood pressure management strategy. Within each stratum, participants will be randomized in a 1:1 ratio to either the stratified blood pressure management strategy group or the guideline-recommended conventional blood pressure management group. The goal is to determine whether this can improve good functional outcomes at 90 days (90-day Modified Rankin Scale \\[mRS\\] score 0-2).\n\nThe study consists of four visits including the day of randomization, 24±4 hours after randomization, 7±1 days after randomization and 90±7 days after randomization. Demographic information, symptoms and signs, laboratory test, neuro-imaging assessment, neurological function rating scale will be recorded during the program.\n\nThe primary outcome is the modified Rankin Scale (mRS) score of 0 to 2 at 90±7 days after randomization. The primary safety outcome is the incidence of sICH within 24±4 hours after randomization.",[69,70,71,72,73],"Endovascular Therapy","Acute Ischaemic Stroke","Collateral Circulation","Blood Pressure Management","Prognosis","NOT_YET_RECRUITING","2026-04-17",{"date":77,"type":78},"2026-04-22","ACTUAL",{"date":80,"type":63},"2026-06-01",{"date":82,"type":63},"2028-02-29",{"name":5,"class":6},1]