[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612334":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":24,"locations":30,"responsibleParty":472,"collaborators":18,"id":474,"slug":18,"hasResults":475,"nctId":476,"briefTitle":477,"officialTitle":478,"acronym":479,"eligibilityCriteria":480,"healthyVolunteers":475,"sex":481,"minAge":482,"maxAge":18,"enrollmentInfo":483,"targetDuration":18,"studyType":486,"phases":487,"briefSummary":489,"conditions":490,"keywords":496,"overallStatus":33,"whyStopped":18,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":511,"completionDateStruct":513,"leadSponsor":515,"locationsCount":516},{"fullName":5,"class":6},"Revolution Medicines, Inc.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"daraxonrasib","EXPERIMENTAL","study drug",[13],"Drug: daraxonrasib",{"label":15,"type":16,"description":17,"interventionNames":18},"SOC Observation","NO_INTERVENTION","Patients randomized to the comparator control arm will receive SOC observation.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"DRUG","oral tablets",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"Revolution Medicines Study Director","CONTACT","1-844-2-REVMED","medinfo@revmed.com",[31,50,64,78,88,103,118,133,148,158,176,186,195,210,225,241,250,261,271,286,301,311,321,334,349,359,370,380,395,408,423,438,452,463],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"University of California, Los Angeles","RECRUITING","Los Angeles","California","90404","United States",{"type":39,"coordinates":40},"Point",[41,42],-118.24368,34.05223,{"lat":42,"lon":41},[45],{"name":46,"role":27,"phone":47,"phoneExt":48,"email":49},"Madeleine Manahan","310-633-8400","x19212","mmanahan@mednet.ucla.edu",{"facility":51,"status":33,"city":52,"state":35,"zip":53,"country":37,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"Stanford Cancer Institute","Palo Alto","94304",{"type":39,"coordinates":55},[56,57],-122.14302,37.44188,{"lat":57,"lon":56},[60],{"name":61,"role":27,"phone":62,"phoneExt":18,"email":63},"Cassandra Blake","650-725-9895","cblake1@stanford.edu",{"facility":65,"status":33,"city":66,"state":35,"zip":67,"country":37,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"University of California, San Francisco","San Francisco","94143",{"type":39,"coordinates":69},[70,71],-122.41942,37.77493,{"lat":71,"lon":70},[74],{"name":75,"role":27,"phone":76,"phoneExt":18,"email":77},"Kevin Lopez","415-502-3310","Kevin.lopez@ucsf.edu",{"facility":79,"status":33,"city":80,"state":81,"zip":82,"country":37,"cosmosGeoPoint":83,"geoPoint":87,"contacts":18},"Rocky Mountain Cancer Centers, LLP","Lakewood","Colorado","80228",{"type":39,"coordinates":84},[85,86],-105.08137,39.70471,{"lat":86,"lon":85},{"facility":89,"status":33,"city":90,"state":91,"zip":92,"country":37,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"Hartford Healthcare","Hartford","Connecticut","06103",{"type":39,"coordinates":94},[95,96],-72.68509,41.76371,{"lat":96,"lon":95},[99],{"name":100,"role":27,"phone":101,"phoneExt":18,"email":102},"Jonathan Steinmetz","860-972-4183","jonathan.steinmetz@hhchealth.org",{"facility":104,"status":33,"city":105,"state":106,"zip":107,"country":37,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"University of Miami Hospital and Clinics, Sylvester Comprehensive Cancer Center","Miami","Florida","33136",{"type":39,"coordinates":109},[110,111],-80.19366,25.77427,{"lat":111,"lon":110},[114],{"name":115,"role":27,"phone":116,"phoneExt":18,"email":117},"Yolanda Justal","305-243-2647","yxj512@med.miami.edu",{"facility":119,"status":33,"city":120,"state":121,"zip":122,"country":37,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"Winship Cancer Institute, Emory University","Atlanta","Georgia","30322",{"type":39,"coordinates":124},[125,126],-84.38798,33.749,{"lat":126,"lon":125},[129],{"name":130,"role":27,"phone":131,"phoneExt":18,"email":132},"Kathleen Coleman","404-251-1278","kathleen.marie.coleman@emory.edu",{"facility":134,"status":33,"city":135,"state":136,"zip":137,"country":37,"cosmosGeoPoint":138,"geoPoint":142,"contacts":143},"Community Health Network","Indianapolis","Indiana","46250",{"type":39,"coordinates":139},[140,141],-86.15804,39.76838,{"lat":141,"lon":140},[144],{"name":145,"role":27,"phone":146,"phoneExt":18,"email":147},"Adam Norris","317-621-3858","anorris@ecommunity.com",{"facility":149,"status":33,"city":150,"state":151,"zip":152,"country":37,"cosmosGeoPoint":153,"geoPoint":157,"contacts":18},"University of Kansas Medical Center Research Institute, Inc.","Lawrence","Kansas","66045",{"type":39,"coordinates":154},[155,156],-95.23525,38.97167,{"lat":156,"lon":155},{"facility":159,"status":33,"city":160,"state":161,"zip":162,"country":37,"cosmosGeoPoint":163,"geoPoint":167,"contacts":168},"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins & Sibley Memorial Hospital","Baltimore","Maryland","21287",{"type":39,"coordinates":164},[165,166],-76.61219,39.29038,{"lat":166,"lon":165},[169,173],{"name":170,"role":27,"phone":171,"phoneExt":18,"email":172},"GI Clinical Trial Referrals","410-614-3644","giclinicaltrials@jhmi.edu",{"name":174,"role":27,"phone":175,"phoneExt":18,"email":18},"Mike Pishvaian","202-660-6500",{"facility":177,"status":33,"city":178,"state":179,"zip":180,"country":37,"cosmosGeoPoint":181,"geoPoint":185,"contacts":18},"Massachusetts General Hospital","Boston","Massachusetts","02114",{"type":39,"coordinates":182},[183,184],-71.05977,42.35843,{"lat":184,"lon":183},{"facility":187,"status":33,"city":178,"state":179,"zip":188,"country":37,"cosmosGeoPoint":189,"geoPoint":191,"contacts":192},"Dana Farber Cancer Institute (DFCI)","02215",{"type":39,"coordinates":190},[183,184],{"lat":184,"lon":183},[193],{"name":18,"role":27,"phone":194,"phoneExt":18,"email":18},"617-632-3000",{"facility":196,"status":33,"city":197,"state":198,"zip":199,"country":37,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"Saint Luke's Cancer Institute","Kansas City","Missouri","64111",{"type":39,"coordinates":201},[202,203],-94.57857,39.09973,{"lat":203,"lon":202},[206],{"name":207,"role":27,"phone":208,"phoneExt":18,"email":209},"Marc Roth","816-932-2677","mroth@saint-lukes.org",{"facility":211,"status":33,"city":212,"state":213,"zip":214,"country":37,"cosmosGeoPoint":215,"geoPoint":219,"contacts":220},"Comprehensive Cancer Centers of Nevada","Las Vegas","Nevada","89169",{"type":39,"coordinates":216},[217,218],-115.13722,36.17497,{"lat":218,"lon":217},[221],{"name":222,"role":27,"phone":223,"phoneExt":18,"email":224},"Ann Lovelace","702-609-9460","ann.lovelace@usoncology.com",{"facility":226,"status":33,"city":227,"state":227,"zip":228,"country":37,"cosmosGeoPoint":229,"geoPoint":233,"contacts":234},"Laura and Issac Perlmutter Cancer Center at NYU Langone-Ambulatory Care Center","New York","10016",{"type":39,"coordinates":230},[231,232],-74.00597,40.71427,{"lat":232,"lon":231},[235,239],{"name":236,"role":27,"phone":237,"phoneExt":18,"email":238},"Mark Bond","212-731-6120","Ct.gov@nyulangone.org",{"name":240,"role":27,"phone":237,"phoneExt":18,"email":238},"Jennifer Coffey",{"facility":242,"status":33,"city":227,"state":227,"zip":243,"country":37,"cosmosGeoPoint":244,"geoPoint":246,"contacts":247},"Columbia University Medical Center","10032",{"type":39,"coordinates":245},[231,232],{"lat":232,"lon":231},[248],{"name":18,"role":27,"phone":18,"phoneExt":18,"email":249},"cancerclinicaltrials@cumc.columbia.edu",{"facility":251,"status":33,"city":227,"state":227,"zip":252,"country":37,"cosmosGeoPoint":253,"geoPoint":255,"contacts":256},"Memorial Sloan Kettering Cancer Center","10065",{"type":39,"coordinates":254},[231,232],{"lat":232,"lon":231},[257],{"name":258,"role":27,"phone":259,"phoneExt":18,"email":260},"Eileen O'Reilly","646-888-4182","oreillye@MSKCC.ORG",{"facility":262,"status":33,"city":263,"state":264,"zip":265,"country":37,"cosmosGeoPoint":266,"geoPoint":270,"contacts":18},"Duke Cancer Center","Durham","North Carolina","27710",{"type":39,"coordinates":267},[268,269],-78.89862,35.99403,{"lat":269,"lon":268},{"facility":272,"status":33,"city":273,"state":274,"zip":275,"country":37,"cosmosGeoPoint":276,"geoPoint":280,"contacts":281},"Taylor Cancer Research Center","Maumee","Ohio","43537",{"type":39,"coordinates":277},[278,279],-83.65382,41.56283,{"lat":279,"lon":278},[282],{"name":283,"role":27,"phone":284,"phoneExt":18,"email":285},"Stephanie Ambrose","567-402-4502","sambrose@tcrcpt.org",{"facility":287,"status":33,"city":288,"state":289,"zip":290,"country":37,"cosmosGeoPoint":291,"geoPoint":295,"contacts":296},"Avera Cancer Institute","Sioux Falls","South Dakota","57105",{"type":39,"coordinates":292},[293,294],-96.72796,43.54369,{"lat":294,"lon":293},[297],{"name":298,"role":27,"phone":299,"phoneExt":18,"email":300},"Heidi McKean","605-322-6900","heidi.mckean@avera.org",{"facility":302,"status":33,"city":303,"state":304,"zip":305,"country":37,"cosmosGeoPoint":306,"geoPoint":310,"contacts":18},"SCRI Oncology Partners","Nashville","Tennessee","37203",{"type":39,"coordinates":307},[308,309],-86.78444,36.16589,{"lat":309,"lon":308},{"facility":312,"status":33,"city":313,"state":314,"zip":315,"country":37,"cosmosGeoPoint":316,"geoPoint":320,"contacts":18},"Texas Oncology - DFW","Dallas","Texas","75246",{"type":39,"coordinates":317},[318,319],-96.80667,32.78306,{"lat":319,"lon":318},{"facility":322,"status":33,"city":323,"state":314,"zip":324,"country":37,"cosmosGeoPoint":325,"geoPoint":329,"contacts":330},"Texas Oncology - Northeast Texas","Longview","75601",{"type":39,"coordinates":326},[327,328],-94.74049,32.5007,{"lat":328,"lon":327},[331],{"name":332,"role":27,"phone":18,"phoneExt":18,"email":333},"Angie Smith","Angie.smith2@usoncology.com",{"facility":335,"status":33,"city":336,"state":337,"zip":338,"country":37,"cosmosGeoPoint":339,"geoPoint":343,"contacts":344},"University of Utah, Huntsman Cancer Institute","Salt Lake City","Utah","94112",{"type":39,"coordinates":340},[341,342],-111.89105,40.76078,{"lat":342,"lon":341},[345],{"name":346,"role":27,"phone":347,"phoneExt":18,"email":348},"Susan Sherry","801-585-3453","susan.sharry@hci.utah.edu",{"facility":350,"status":33,"city":351,"state":352,"zip":353,"country":37,"cosmosGeoPoint":354,"geoPoint":358,"contacts":18},"Virginia Cancer Specialists","Fairfax","Virginia","22031",{"type":39,"coordinates":355},[356,357],-77.30637,38.84622,{"lat":357,"lon":356},{"facility":360,"status":33,"city":361,"state":362,"zip":363,"country":364,"cosmosGeoPoint":365,"geoPoint":369,"contacts":18},"Hôpital Paul Brousse","Villejuif","Val-De- Marne","94804","France",{"type":39,"coordinates":366},[367,368],2.35992,48.7939,{"lat":368,"lon":367},{"facility":371,"status":33,"city":372,"state":18,"zip":373,"country":374,"cosmosGeoPoint":375,"geoPoint":379,"contacts":18},"IEO - Instituto Europeo di Oncologia","Milan","20141","Italy",{"type":39,"coordinates":376},[377,378],12.59836,42.78235,{"lat":378,"lon":377},{"facility":381,"status":33,"city":382,"state":383,"zip":384,"country":385,"cosmosGeoPoint":386,"geoPoint":390,"contacts":391},"Kanagawa Cancer Center","Yokohama","Kanagawa","241-8515","Japan",{"type":39,"coordinates":387},[388,389],139.65,35.43333,{"lat":389,"lon":388},[392],{"name":393,"role":27,"phone":18,"phoneExt":18,"email":394},"Makoto Ueno","kccmakoto23u@gmail.com",{"facility":396,"status":33,"city":397,"state":18,"zip":398,"country":385,"cosmosGeoPoint":399,"geoPoint":403,"contacts":404},"Cancer Institute Hospital of JFCR","Tokyo","135-8550",{"type":39,"coordinates":400},[401,402],139.69171,35.6895,{"lat":402,"lon":401},[405],{"name":406,"role":27,"phone":18,"phoneExt":18,"email":407},"Masato Ozaka","masato.ozaka@jfcr.or.jp",{"facility":409,"status":33,"city":410,"state":18,"zip":411,"country":412,"cosmosGeoPoint":413,"geoPoint":417,"contacts":418},"Pan American Oncology Trials, LLC","San Juan","00909","Puerto Rico",{"type":39,"coordinates":414},[415,416],-66.10572,18.46633,{"lat":416,"lon":415},[419],{"name":420,"role":27,"phone":421,"phoneExt":18,"email":422},"Principal Investigator","787-407-3333","info@panoncologytrials.com",{"facility":424,"status":33,"city":425,"state":18,"zip":426,"country":427,"cosmosGeoPoint":428,"geoPoint":432,"contacts":433},"University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Medical Centre","Birmingham","B15 2TH","United Kingdom",{"type":39,"coordinates":429},[430,431],-1.89983,52.48142,{"lat":431,"lon":430},[434],{"name":435,"role":27,"phone":436,"phoneExt":18,"email":437},"Shivan Shivakumar","0121 371 3571","Shivan.Sivakumar@uhb.nhs.uk",{"facility":439,"status":33,"city":440,"state":18,"zip":441,"country":427,"cosmosGeoPoint":442,"geoPoint":446,"contacts":447},"The Royal Marsden NHS Foundation Trust, Royal Marsden Hospital-London","London","SW3 6JJ",{"type":39,"coordinates":443},[444,445],-0.12574,51.50853,{"lat":445,"lon":444},[448],{"name":449,"role":27,"phone":450,"phoneExt":18,"email":451},"Naureen Starling","02078118460","gitrials@rmh.nhs.uk",{"facility":453,"status":33,"city":440,"state":18,"zip":454,"country":427,"cosmosGeoPoint":455,"geoPoint":457,"contacts":458},"Imperial College Healthcare NHS Foundation Trust, Hammersmith Hospital","W12 0HS",{"type":39,"coordinates":456},[444,445],{"lat":445,"lon":444},[459],{"name":460,"role":27,"phone":461,"phoneExt":18,"email":462},"Michela Cicchetti","0203 313 8364","michela.cicchetti@nhs.ne",{"facility":464,"status":33,"city":465,"state":18,"zip":466,"country":427,"cosmosGeoPoint":467,"geoPoint":471,"contacts":18},"The Christie NHS Foundation Trust","Manchester","M20 4BX",{"type":39,"coordinates":468},[469,470],-2.23743,53.48095,{"lat":470,"lon":469},{"type":473,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100612334",false,"NCT07252232","Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)","RASolute 304: A Phase 3 Multicenter, Open-label, Randomized, 2-Arm Study of Adjuvant Daraxonrasib Versus Standard of Care Observation Following Completion of Neoadjuvant and\u002For Adjuvant Chemotherapy in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)","RASolute 304","Inclusion Criteria:\n\n* At least 18 years old and has provided informed consent.\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.\n* Histologically confirmed PDAC with successful (R0\u002FR1) curative intent surgical resection and no evidence of recurrent or metastatic disease.\n* Must have received perioperative (neoadjuvant, adjuvant, or a combination of both) multi-agent chemotherapy.\n* Must have completed most recent treatment within the past 12 weeks.\n* Adequate organ function (bone marrow, liver, kidney, coagulation).\n* Documented RAS mutation status.\n* Able to take oral medications.\n\nExclusion Criteria:\n\n* Prior therapy with direct RAS-targeted therapy (eg. degraders and\u002For inhibitors).\n* Any conditions that may affect the ability to take or absorb study drug.\n* Major surgery within 28 days prior to randomization.\n* Patient is unable or unwilling to comply with protocol-required study visits or procedures.","ALL","18 Years",{"count":484,"type":485},500,"ESTIMATED","INTERVENTIONAL",[488],"PHASE3","The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard of care (SOC) observation only.",[491,492,493,494,495],"Pancreatic Cancer","PDAC","PDAC - Pancreatic Ductal Adenocarcinoma","Resectable Pancreatic Ductal Adenocarcinoma (PDAC)","Resected Pancreatic Adenocarcinoma",[491,492,497,498,499,500,501,502,503,504,505,495,506],"Pancreatic Ductal Adenocarcinoma","RAS","KRAS","NRAS","HRAS","RAS Wild-Type","RASolute","Resectable Pancreatic Ductal Adenocarcinoma","Resectable PDAC","RAS Mutation","2026-06-17",{"date":509,"type":510},"2026-06-22","ACTUAL",{"date":512,"type":510},"2025-12-15",{"date":514,"type":485},"2030-07-10",{"name":5,"class":6},34]