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Phase 1\u002F2 is an open-label, single arm, sequential dose escalation. Phase 3 is a multicenter, double-blind, randomized, parallel group, sham controlled study.","TREATMENT",{"masking":30,"maskingDescription":31,"whoMasked":32},"TRIPLE","This is a two-phase study. Phase 1\u002F2 is open-label and unmasked. Phase 3 is blinded with participant, part of investigator team, and outcomes assessor masked to treatment assignment.",[33,34,35],"PARTICIPANT","INVESTIGATOR","OUTCOMES_ASSESSOR","Subjects will undergo a single CT or MRI-guided intracerebral administration of human interneurons that secrete the inhibitory neurotransmitter, gamma-aminobutyric acid (GABA), into the temporal lobe region of the brain where the seizures are thought to arise. NRTX-1001 is intended to suppress the onset and spread of seizures. Safety, efficacy, tolerability, and effects on reducing seizure frequency and epilepsy disease symptoms will be assessed at regular intervals for 2 years after the administration of NRTX-1001. After the two-year period, subjects will be followed with quarterly phone calls and annual visits in years 3 through 5, and then annual visits in years 6 through 15. Subjects will be placed on an immunosuppressant medication regimen for a duration of one year to partially suppress the subjects' immune system to promote the intended long-term persistence of NRTX-1001. This immunosuppressant medication is intended to be discontinued after the first year; however, the NRTX-1001 cells are intended to persist long-term.",[38,44,48],{"label":39,"type":40,"description":41,"interventionNames":42},"NRTX-1001 (Phase 1\u002F2)","EXPERIMENTAL","Up to 28 subjects",[43],"Biological: NRTX-1001",{"label":45,"type":40,"description":46,"interventionNames":47},"NRTX-1001 (Phase 3)","Approximately 40 subjects",[43],{"label":49,"type":50,"description":51,"interventionNames":52},"Sham Comparator (Phase 3)","SHAM_COMPARATOR","Approximately 20 subjects",[53],"Procedure: Sham Comparator",[55,62,65],{"type":56,"name":57,"description":58,"armGroupLabels":59,"otherNames":60},"BIOLOGICAL","NRTX-1001","Biological: NRTX-1001 is an experimental neural cell therapy product candidate derived from an allogeneic human embryonic stem cell line. 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MA","650-460-9260","jseliger@stanford.edu",{"name":216,"role":103,"phone":23,"phoneExt":23,"email":23},"Kevin Graber, MD",{"facility":218,"status":85,"city":219,"state":158,"zip":220,"country":89,"countryCode":90,"cosmosGeoPoint":221,"geoPoint":225,"contacts":226},"University of California Davis","Sacramento","95817",{"type":92,"coordinates":222},[223,224],-121.4944,38.58157,{"lat":224,"lon":223},[227,231],{"name":228,"role":76,"phone":229,"phoneExt":23,"email":230},"Evan Y Shen, BA","916-734-3009","evshen@ucdavis.edu",{"name":232,"role":103,"phone":23,"phoneExt":23,"email":23},"Jack J Lin, MD",{"facility":234,"status":85,"city":235,"state":158,"zip":236,"country":89,"countryCode":90,"cosmosGeoPoint":237,"geoPoint":241,"contacts":242},"University of California San Diego","San Diego","92037",{"type":92,"coordinates":238},[239,240],-117.16472,32.71571,{"lat":240,"lon":239},[243,247],{"name":244,"role":76,"phone":245,"phoneExt":23,"email":246},"Mateo Santizo","858-583-0929","msantizo@health.ucsd.edu",{"name":248,"role":103,"phone":23,"phoneExt":23,"email":23},"Jerry J Shih, MD",{"facility":250,"status":85,"city":251,"state":158,"zip":252,"country":89,"countryCode":90,"cosmosGeoPoint":253,"geoPoint":257,"contacts":258},"University of California San Francisco","San Francisco","94143",{"type":92,"coordinates":254},[255,256],-122.41942,37.77493,{"lat":256,"lon":255},[259,263],{"name":260,"role":76,"phone":261,"phoneExt":23,"email":262},"Sydnie Beausoleil","631-428-9688","Sydnie.Beausoleil@ucsf.edu",{"name":264,"role":103,"phone":23,"phoneExt":23,"email":23},"Robert C Knowlton, MD",{"facility":266,"status":85,"city":267,"state":268,"zip":269,"country":89,"countryCode":90,"cosmosGeoPoint":270,"geoPoint":274,"contacts":275},"University of Colorado Anschutz Medical Campus","Aurora","Colorado","80045",{"type":92,"coordinates":271},[272,273],-104.83192,39.72943,{"lat":273,"lon":272},[276,280],{"name":277,"role":76,"phone":278,"phoneExt":23,"email":279},"Trey Jouard, MS","970-817-4272","Trey.Jouard@cuanschutz.edu",{"name":281,"role":103,"phone":23,"phoneExt":23,"email":23},"Lesley Kaye, MD",{"facility":283,"status":85,"city":284,"state":285,"zip":286,"country":89,"countryCode":90,"cosmosGeoPoint":287,"geoPoint":291,"contacts":292},"George Washington University","Washington D.C.","District of Columbia","20037",{"type":92,"coordinates":288},[289,290],-77.03637,38.89511,{"lat":290,"lon":289},[293,297],{"name":294,"role":76,"phone":295,"phoneExt":23,"email":296},"Preethy Feit, SC","202-677-6765","pfeit@mfa.gwu.edu",{"name":298,"role":103,"phone":23,"phoneExt":23,"email":23},"Mohamad Koubeissi, MD",{"facility":300,"status":85,"city":301,"state":302,"zip":303,"country":89,"countryCode":90,"cosmosGeoPoint":304,"geoPoint":308,"contacts":309},"University of Miami","Miami","Florida","33136",{"type":92,"coordinates":305},[306,307],-80.19366,25.77427,{"lat":307,"lon":306},[310,314],{"name":311,"role":76,"phone":312,"phoneExt":23,"email":313},"Letitia Fisher","305-775-8582","lfisher@miami.edu",{"name":315,"role":103,"phone":23,"phoneExt":23,"email":23},"Jonathan R. Jagid, MD",{"facility":317,"status":85,"city":318,"state":319,"zip":320,"country":89,"countryCode":90,"cosmosGeoPoint":321,"geoPoint":325,"contacts":326},"Rush University Medical Center","Chicago","Illinois","60612",{"type":92,"coordinates":322},[323,324],-87.65005,41.85003,{"lat":324,"lon":323},[327,331],{"name":328,"role":76,"phone":329,"phoneExt":23,"email":330},"Amanda Sremac, BS","312-942-0539","Amanda_C_Sremac@rush.edu",{"name":332,"role":103,"phone":23,"phoneExt":23,"email":23},"Rebecca O'Dwyer, MD",{"facility":334,"status":85,"city":318,"state":319,"zip":335,"country":89,"countryCode":90,"cosmosGeoPoint":336,"geoPoint":338,"contacts":339},"University of Chicago","60637",{"type":92,"coordinates":337},[323,324],{"lat":324,"lon":323},[340,344],{"name":341,"role":76,"phone":342,"phoneExt":23,"email":343},"Agnieszka Stadnik, MS","773-702-8996","astadnik@bsd.uchicago.edu",{"name":345,"role":103,"phone":23,"phoneExt":23,"email":23},"Peter Warnke, MD",{"facility":347,"status":85,"city":348,"state":349,"zip":350,"country":89,"countryCode":90,"cosmosGeoPoint":351,"geoPoint":355,"contacts":356},"University of Iowa Health Care","Iowa City","Iowa","52242",{"type":92,"coordinates":352},[353,354],-91.53017,41.66113,{"lat":354,"lon":353},[357,361],{"name":358,"role":76,"phone":359,"phoneExt":23,"email":360},"Loraine Brenner, MSN","319-356-4361","loraine-brenner@uiowa.edu",{"name":362,"role":103,"phone":23,"phoneExt":23,"email":23},"Mark Granner, MD",{"facility":364,"status":85,"city":365,"state":366,"zip":367,"country":89,"countryCode":90,"cosmosGeoPoint":368,"geoPoint":372,"contacts":373},"Ochsner Clinic Foundation","New Orleans","Louisiana","70121",{"type":92,"coordinates":369},[370,371],-90.07507,29.95465,{"lat":371,"lon":370},[374,378],{"name":375,"role":76,"phone":376,"phoneExt":23,"email":377},"Neydin Osorio, BS, CRC","504-703-5577","neydin.tejeda@ochsner.org",{"name":379,"role":103,"phone":23,"phoneExt":23,"email":23},"Fawad Khan, MD",{"facility":381,"status":85,"city":382,"state":383,"zip":384,"country":89,"countryCode":90,"cosmosGeoPoint":385,"geoPoint":389,"contacts":390},"Beth Israel Deaconess Medical Center","Boston","Massachusetts","02215",{"type":92,"coordinates":386},[387,388],-71.05977,42.35843,{"lat":388,"lon":387},[391,395],{"name":392,"role":76,"phone":393,"phoneExt":23,"email":394},"Anna George, MSc","617-632-7031","ageorge5@bidmc.harvard.edu",{"name":396,"role":103,"phone":23,"phoneExt":23,"email":23},"Joshua P Aronson, MD",{"facility":398,"status":85,"city":399,"state":400,"zip":401,"country":89,"countryCode":90,"cosmosGeoPoint":402,"geoPoint":406,"contacts":407},"Wayne State University\u002FDetroit Medical Center Comprehensive Epilepsy Program","Detroit","Michigan","48201",{"type":92,"coordinates":403},[404,405],-83.04575,42.33143,{"lat":405,"lon":404},[408,412],{"name":409,"role":76,"phone":410,"phoneExt":23,"email":411},"Kelly X Jia, MD","313-966-9407","xjia@med.wayne.edu",{"name":413,"role":103,"phone":23,"phoneExt":23,"email":23},"Maysaa Basha, MD",{"facility":415,"status":85,"city":416,"state":417,"zip":418,"country":89,"countryCode":90,"cosmosGeoPoint":419,"geoPoint":423,"contacts":424},"Washington University at St. Louis","St Louis","Missouri","63100",{"type":92,"coordinates":420},[421,422],-90.19789,38.62727,{"lat":422,"lon":421},[425,429],{"name":426,"role":76,"phone":427,"phoneExt":23,"email":428},"Victoria Taylor, SC","314-362-7871","v.taylor@wustl.edu",{"name":430,"role":103,"phone":23,"phoneExt":23,"email":23},"R. Edward Hogan, MD",{"facility":432,"status":85,"city":433,"state":434,"zip":435,"country":89,"countryCode":90,"cosmosGeoPoint":436,"geoPoint":440,"contacts":441},"Dartmouth Hitchcock Medical Center\u002F Department of Neurology","Lebanon","New Hampshire","03756",{"type":92,"coordinates":437},[438,439],-72.25176,43.64229,{"lat":439,"lon":438},[442,446],{"name":443,"role":76,"phone":444,"phoneExt":23,"email":445},"Anastasia Kanishcheva, PM","603) 650-0260","anastasia.kanishcheva@hitchcock.org",{"name":447,"role":103,"phone":23,"phoneExt":23,"email":23},"Krzysztof A, Bujarski, MD",{"facility":449,"status":85,"city":450,"state":451,"zip":452,"country":89,"countryCode":90,"cosmosGeoPoint":453,"geoPoint":457,"contacts":458},"Hofstra Northwell Comprehensive Epilepsy Center","Great Neck","New York","11021",{"type":92,"coordinates":454},[455,456],-73.72846,40.80066,{"lat":456,"lon":455},[459,463],{"name":460,"role":76,"phone":461,"phoneExt":23,"email":462},"Isabella Henderson","212-434-4837","IHenderson@northwell.edu",{"name":464,"role":103,"phone":23,"phoneExt":23,"email":23},"Sean Hwang, MD",{"facility":466,"status":85,"city":451,"state":451,"zip":467,"country":89,"countryCode":90,"cosmosGeoPoint":468,"geoPoint":472,"contacts":473},"NYU Langone Comprehensive Epilepsy Center","10016",{"type":92,"coordinates":469},[470,471],-74.00597,40.71427,{"lat":471,"lon":470},[474,478],{"name":475,"role":76,"phone":476,"phoneExt":23,"email":477},"Jack C Carter, BS","646-558-0841","jack.carter@nyulangone.org",{"name":479,"role":103,"phone":23,"phoneExt":23,"email":23},"Orrin Devinsky, MD",{"facility":481,"status":85,"city":482,"state":451,"zip":483,"country":89,"countryCode":90,"cosmosGeoPoint":484,"geoPoint":488,"contacts":489},"SUNY Upstate Medical University","Syracuse","13210",{"type":92,"coordinates":485},[486,487],-76.14742,43.04812,{"lat":487,"lon":486},[490,494],{"name":491,"role":76,"phone":492,"phoneExt":23,"email":493},"Lena F Deb, 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Benitez-Rosas","919-681-4974","Hazani.benitez-rosas@duke.edu",{"name":528,"role":103,"phone":23,"phoneExt":23,"email":23},"Derek Southwell, MD, PhD",{"facility":530,"status":85,"city":531,"state":499,"zip":532,"country":89,"countryCode":90,"cosmosGeoPoint":533,"geoPoint":537,"contacts":538},"Atrium Wake Forest Baptist","Winston-Salem","27157",{"type":92,"coordinates":534},[535,536],-80.24422,36.09986,{"lat":536,"lon":535},[539,543],{"name":540,"role":76,"phone":541,"phoneExt":23,"email":542},"Carolyn W Hedrick, RMA, CCRP","336-716-8694","cwhedric@wakehealth.edu",{"name":544,"role":103,"phone":23,"phoneExt":23,"email":23},"Gautam S Popli, MBBS, MBA",{"facility":546,"status":85,"city":547,"state":548,"zip":549,"country":89,"countryCode":90,"cosmosGeoPoint":550,"geoPoint":554,"contacts":555},"Oregon Health and Science University","Portland","Oregon","97239",{"type":92,"coordinates":551},[552,553],-122.67621,45.52345,{"lat":553,"lon":552},[556,560],{"name":557,"role":76,"phone":558,"phoneExt":23,"email":559},"Claire Dorfman, BA","971-413-9201","dorfman@ohsu.edu",{"name":561,"role":103,"phone":23,"phoneExt":23,"email":23},"David C Spencer, MD",{"facility":563,"status":85,"city":564,"state":565,"zip":566,"country":89,"countryCode":90,"cosmosGeoPoint":567,"geoPoint":571,"contacts":572},"Thomas Jefferson University Hospital","Philadelphia","Pennsylvania","19107",{"type":92,"coordinates":568},[569,570],-75.16362,39.95238,{"lat":570,"lon":569},[573,577],{"name":574,"role":76,"phone":575,"phoneExt":23,"email":576},"Latasha Adams, MBS","215-955-2606","Latasha.adams2@jefferson.edu",{"name":578,"role":103,"phone":23,"phoneExt":23,"email":23},"Michael Sperling, MD",{"facility":580,"status":85,"city":581,"state":582,"zip":583,"country":89,"countryCode":90,"cosmosGeoPoint":584,"geoPoint":588,"contacts":589},"UT Southwestern Medical Center","Dallas","Texas","75390",{"type":92,"coordinates":585},[586,587],-96.80667,32.78306,{"lat":587,"lon":586},[590,594],{"name":591,"role":76,"phone":592,"phoneExt":23,"email":593},"Vamsi Vemireddy, SC","214-645-8159","vamsidhara.vemireddy@utsouthwestern.edu",{"name":595,"role":103,"phone":23,"phoneExt":23,"email":23},"Sasha Alick-Lindstrom, MD",{"facility":597,"status":85,"city":598,"state":582,"zip":599,"country":89,"countryCode":90,"cosmosGeoPoint":600,"geoPoint":604,"contacts":605},"UTHealth Houston","Houston","77030",{"type":92,"coordinates":601},[602,603],-95.36327,29.76328,{"lat":603,"lon":602},[606,610],{"name":607,"role":76,"phone":608,"phoneExt":23,"email":609},"Eliana M Klier, PhD","713-500-5442","Eliana.Klier@uth.tmc.edu",{"name":611,"role":103,"phone":23,"phoneExt":23,"email":23},"Nitin Tandon, MD",{"facility":613,"status":85,"city":614,"state":615,"zip":616,"country":89,"countryCode":90,"cosmosGeoPoint":617,"geoPoint":621,"contacts":622},"University of Utah Health","Salt Lake City","Utah","84108",{"type":92,"coordinates":618},[619,620],-111.89105,40.76078,{"lat":620,"lon":619},[623,627],{"name":624,"role":76,"phone":625,"phoneExt":23,"email":626},"Laura Beeler, BS","928-530-7990","laura.beeler@hsc.utah.edu",{"name":628,"role":103,"phone":23,"phoneExt":23,"email":23},"Amir Arain, MD",{"facility":630,"status":85,"city":631,"state":632,"zip":633,"country":89,"countryCode":90,"cosmosGeoPoint":634,"geoPoint":638,"contacts":639},"University of Washington Regional Epilepsy Center","Seattle","Washington","98104",{"type":92,"coordinates":635},[636,637],-122.33207,47.60621,{"lat":637,"lon":636},[640,644],{"name":641,"role":76,"phone":642,"phoneExt":23,"email":643},"Jennifer Steele, CRC","206-744-2336","recresearch@uw.edu",{"name":645,"role":103,"phone":23,"phoneExt":23,"email":23},"Shahin Hakimian, MD, PhD",{"facility":647,"status":85,"city":648,"state":649,"zip":650,"country":89,"countryCode":90,"cosmosGeoPoint":651,"geoPoint":655,"contacts":656},"Medical College of Wisconsin","Milwaukee","Wisconsin","53226",{"type":92,"coordinates":652},[653,654],-87.90647,43.0389,{"lat":654,"lon":653},[657,661],{"name":658,"role":76,"phone":659,"phoneExt":23,"email":660},"Sarah Young, MS","414-955-0989","scyoung@mcw.edu",{"name":662,"role":103,"phone":23,"phoneExt":23,"email":23},"Sean Lew, MD",{"type":664,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR",[666],{"name":667,"class":668},"California Institute for Regenerative Medicine (CIRM)","OTHER","100449638",false,"NCT05135091","Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))","A Study of Inhibitory Interneurons (NRTX-1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)","EPIC","Key Inclusion Criteria:\n\n1. Male or Female, age ≥18 to ≤75\n2. Focal seizures, clinically defined as unilateral MTLE\n3. Has failed to achieve seizure control despite adequate trials of at least 2 ASDs at appropriate doses\n4. Currently on stable doses (at least 1 month prior to Screening) of approved ASDs\n5. Single seizure focus confirmed within one hippocampus\n6. Seizure frequency averages ≥4 per 28-day period, including at least 2 clinical focal seizures per 28-day period with objective manifestations or more severe types, over the 6 months prior to the Screening Visit. (Phase 1\u002F2 only)\n7. Disabling seizure frequency of ≥2 per 28-day period averaged over 3 months prior to the Screening visit and over a prospective 10-week baseline period prior to Randomization (Phase 3 Only)\n\nKey Exclusion Criteria:\n\n1. Epilepsy due to other medical conditions and\u002For progressive neurologic disease\n2. Evidence of seizure focus outside of the hippocampus or evidence of seizures of non- focal origin.\n3. Significant other medical conditions which would impair safe participation\n4. History of status epilepticus in the 3 years prior to screening.\n5. Primary or secondary immunodeficiency\n6. Suicide attempts in the past year 3 years\n7. Severe psychiatric disorders\n8. Prior lobectomy or LITT procedure\n9. MRI indicating potential malignant lesion\n10. Pregnancy, or currently breastfeeding.","ALL","18 Years","75 Years",{"count":680,"type":681},88,"ESTIMATED","INTERVENTIONAL",[684],"PHASE3","This clinical trial is designed to test whether a single image-guided intracerebral administration of inhibitory nerve cells, called interneurons (NRTX-1001), into subjects with drug-resistant unilateral mesial temporal lobe epilepsy (MTLE), with or without mesial temporal sclerosis (MTS), is safe (frequency of adverse events) and effective (seizure frequency). NRTX-1001 comprises human interneurons that secrete a neurotransmitter, gamma-aminobutyric acid (GABA).",[687],"Mesial Temporal Lobe Epilepsy",[689,690,691,674,692,693],"Epilepsy","MTLE","seizure","focal seizures","hippocampus","2026-06-06",{"date":696,"type":697},"2026-06-09","ACTUAL",{"date":699,"type":697},"2022-06-16",{"date":701,"type":681},"2043-09",{"name":5,"class":6},35]