[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577802":3},{"organization":4,"outcomesModule":7,"designInfo":19,"detailedDescription":27,"studyPopulation":18,"armGroups":28,"interventions":45,"overallOfficials":18,"centralContacts":65,"locations":71,"responsibleParty":91,"collaborators":95,"id":98,"slug":18,"hasResults":99,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":18,"eligibilityCriteria":103,"healthyVolunteers":99,"sex":104,"minAge":105,"maxAge":106,"enrollmentInfo":107,"targetDuration":18,"studyType":110,"phases":111,"briefSummary":113,"conditions":114,"keywords":116,"overallStatus":74,"whyStopped":18,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":124,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},{"fullName":5,"class":6},"Bir Hospital","OTHER_GOV",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":18},[9],{"measure":10,"description":11,"timeFrame":12},"alleviating Ureteral stent related symptoms","mitigating the ureteric stent related symptoms using structured questionnaire","2 weeks",[14],{"measure":15,"description":16,"timeFrame":17},"early removal of ureteral stent","early removal of stent due to stent migration, fever, urosepsis","before 2 weeks",null,{"allocation":20,"interventionModel":21,"interventionModelDescription":18,"primaryPurpose":22,"observationalModel":18,"timePerspective":18,"maskingInfo":23},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":24,"maskingDescription":18,"whoMasked":25},"SINGLE",[26],"PARTICIPANT","Ureteral stent related symptoms can be a major issue in patient undergoing stent placement after any procedure such as- complains of pain, urinary symptoms, sex related and work related and other symptoms. These symptoms can be alleviated with use of drugs such as Tamsulosin, Solifenacin and Mirabegron. Patient recruited in each arm of the study will have their stent related symptoms scoring done using a validated outcome assessment tool to measure the ureteral stent-related symptoms, Ureteral Stent Symptom Questionnaire (USSQ) on day 1, day 7 and day 14 after the stent placement.",[29,35,40],{"label":30,"type":31,"description":32,"interventionNames":33},"Tamsulosin group","ACTIVE_COMPARATOR","placement of ureteral stents followed by Cap. Tamsulosin 0.4 mg once daily, to relieve the symptom",[34],"Drug: Tamsulosin Hydrochloride 0.4 mg",{"label":36,"type":31,"description":37,"interventionNames":38},"Solifenacin group","placement of ureteral stents followed by Tab Solifenacin 5 mg once daily, to relieve the symptom",[39],"Drug: Solifenacin Succinate 5 mg",{"label":41,"type":31,"description":42,"interventionNames":43},"Mirabegron group","placement of ureteral stents followed by Tab. Mirabegron 25 mg once daily, to relieve the symptom",[44],"Drug: Mirabegron 25 mg",[46,53,59],{"type":47,"name":48,"description":49,"armGroupLabels":50,"otherNames":51},"DRUG","Tamsulosin Hydrochloride 0.4 mg","placement of ureteral stents followed by Cap. Tamsulosin 0.4 mg once daily",[30],[52],"Cap. Urimax 0.4 mg",{"type":47,"name":54,"description":55,"armGroupLabels":56,"otherNames":57},"Solifenacin Succinate 5 mg","placement of ureteral stents followed by Tab. Solifenacin 5 mg once daily",[36],[58],"Tab. Solay 5 mg",{"type":47,"name":60,"description":61,"armGroupLabels":62,"otherNames":63},"Mirabegron 25 mg","placement of ureteral stents followed by Tab. Mirabegron 25 mg once daily",[41],[64],"Tab. Mirasin 25 mg",[66],{"name":67,"role":68,"phone":69,"phoneExt":18,"email":70},"Baikuntha Adhikari, MCh","CONTACT","+977 9849896780","baikadhe@gmail.com",[72],{"facility":73,"status":74,"city":75,"state":76,"zip":77,"country":78,"countryCode":79,"cosmosGeoPoint":80,"geoPoint":85,"contacts":86},"NAMS, Bir Hospital","RECRUITING","Kathmandu","Bagmati","44600","Nepal","NP",{"type":81,"coordinates":82},"Point",[83,84],85.3206,27.70169,{"lat":84,"lon":83},[87],{"name":88,"role":68,"phone":89,"phoneExt":18,"email":90},"Jainendra K Manoj, Dr","9841529629","drjkmanoj@gmail.com",{"type":92,"investigatorFullName":93,"investigatorTitle":94,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Jainendra Kumar Manoj","M Ch Urology Resident",[96],{"name":97,"class":6},"Nepal Health Research Council","100577802",false,"NCT06803030","Study of Tamsulosin, Solifenacin and Mirabegron in Alleviating Ureteral Stent-related Symptoms","A Comparative Study on the Efficacy of Tamsulosin, Solifenacin and Mirabegron in Alleviating Ureteral Stent-related Symptoms: a Randomized Controlled Trial","Inclusion Criteria:\n\n• Eligible participants were adult patients (aged 19-80 years) who underwent unilateral retrograde rigid ureteroscopy (URS) or retrograde intrarenal surgery (RIRS) with planned ureteric stent insertion for urinary tract stones\n\nExclusion Criteria:\n\n* Concomitant use of a-blockers, anticholinergics, corticosteroids, calcium channel blockers, and analgesics\n* Undergoing percutaneous nephrolithotomy, open ureteric surgery or laparoscopic ureteric surgery, including ureterolithotomy\n* Neurogenic bladder, Over Active Bladder (OAB) syndrome, and neurological and psychiatric diseases\n* Preoperative febrile Urinary Tract Infection (UTI)\n* Pregnancy or breastfeeding;\n* A single kidney\n* Moderate or severe cardiovascular or cerebrovascular disease\n* Hepatic dysfunction\n* History of pelvic surgery or irradiation\n* History of bladder or prostate surgery\n* Other acute medical conditions (including acute pancreatitis, acute gastroenteritis, musculoskeletal disorders) that might influence the Ureteral Stent Symptom Questionnaire(USSQ) pain score\n* Allergy to any medication","ALL","18 Years","80 Years",{"count":108,"type":109},189,"ESTIMATED","INTERVENTIONAL",[112],"PHASE3","A comparative study on the efficacy of Tamsulosin, Solifenacin and Mirabegron in alleviating ureteral stent-related symptoms: a randomized controlled trial.",[115],"Ureteral Stent-Related Symptom",[117,118,119],"Mirabegron","Tamsulosin","Solifenacin","2025-08-30",{"date":122,"type":123},"2025-09-08","ACTUAL",{"date":120,"type":123},{"date":126,"type":109},"2026-12-31",{"name":5,"class":6},1]