[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640974":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":31,"responsibleParty":186,"collaborators":26,"id":188,"slug":26,"hasResults":189,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":189,"sex":195,"minAge":196,"maxAge":197,"enrollmentInfo":198,"targetDuration":26,"studyType":201,"phases":202,"briefSummary":204,"conditions":205,"keywords":207,"overallStatus":144,"whyStopped":26,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":222},{"fullName":5,"class":6},"Sun Pharma Japan Limited","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Deuruxolitinib 8 mg","EXPERIMENTAL","Participants in this arm will receive deuruxolitinib 8 mg administered orally twice daily (BID) during the 24-week double-blind treatment period and continue to receive deuruxolitinib 8 mg administered orally BID up to 52 weeks",[13],"Drug: Deuruxolitinib",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Participants in this arm will receive matching placebo administered orally BID during the 24-week double-blind treatment period and then receive deuruxolitinib 8 mg administered orally BID up to 52 weeks.",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Deuruxolitinib","Deuruxolitinib will be dosed orally as tablets at a dose of 8 mg",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"Deuruxolitinib matching placebo will be dosed orally as tablets for up to 24 weeks and then deuruxolitinib will be dosed for up to 52 weeks",[15],[23],[32,44,53,62,71,80,89,98,107,116,125,129,133,142,158,164,173,177],{"facility":33,"status":34,"city":35,"state":26,"zip":36,"country":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":26},"Study Site 102","NOT_YET_RECRUITING","Asahikawa","078-8510","Japan",{"type":39,"coordinates":40},"Point",[41,42],142.36489,43.77063,{"lat":42,"lon":41},{"facility":45,"status":34,"city":46,"state":26,"zip":47,"country":37,"cosmosGeoPoint":48,"geoPoint":52,"contacts":26},"Study Site 117","Bunkyō City","113-8431",{"type":39,"coordinates":49},[50,51],139.4217,35.5331,{"lat":51,"lon":50},{"facility":54,"status":34,"city":55,"state":26,"zip":56,"country":37,"cosmosGeoPoint":57,"geoPoint":61,"contacts":26},"Study Site 119","Ebina","243-0432",{"type":39,"coordinates":58},[59,60],139.39651,35.38121,{"lat":60,"lon":59},{"facility":63,"status":34,"city":64,"state":26,"zip":65,"country":37,"cosmosGeoPoint":66,"geoPoint":70,"contacts":26},"Study Site 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114","Miyagi-gun","981-0112",{"facility":134,"status":34,"city":135,"state":26,"zip":136,"country":37,"cosmosGeoPoint":137,"geoPoint":141,"contacts":26},"Study Site 104","Niigata","951-8520",{"type":39,"coordinates":138},[139,140],139.04125,37.92259,{"lat":140,"lon":139},{"facility":143,"status":144,"city":145,"state":26,"zip":146,"country":37,"cosmosGeoPoint":147,"geoPoint":151,"contacts":152},"Study Site 109","RECRUITING","Osaka","542-0081",{"type":39,"coordinates":148},[149,150],135.50107,34.69379,{"lat":150,"lon":149},[153],{"name":154,"role":155,"phone":156,"phoneExt":26,"email":157},"Inui","CONTACT","+81-6-6484-5755","JPS.clinicaltrial@sunpharma.com",{"facility":159,"status":34,"city":145,"state":26,"zip":160,"country":37,"cosmosGeoPoint":161,"geoPoint":163,"contacts":26},"Study Site 108","545-0051",{"type":39,"coordinates":162},[149,150],{"lat":150,"lon":149},{"facility":165,"status":34,"city":166,"state":26,"zip":167,"country":37,"cosmosGeoPoint":168,"geoPoint":172,"contacts":26},"Study Site 103","Sapporo","060-8648",{"type":39,"coordinates":169},[170,171],141.35,43.06667,{"lat":171,"lon":170},{"facility":174,"status":34,"city":175,"state":26,"zip":176,"country":37,"cosmosGeoPoint":26,"geoPoint":26,"contacts":26},"Study Site 105","Shinjuku-Ku","160-0023",{"facility":178,"status":34,"city":179,"state":26,"zip":180,"country":37,"cosmosGeoPoint":181,"geoPoint":185,"contacts":26},"Study Site 111","Ube","755-8505",{"type":39,"coordinates":182},[183,184],131.25111,33.94306,{"lat":184,"lon":183},{"type":187,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100640974",false,"NCT07617597","Study to Evaluate the Efficacy and Safety of Deuruxolitinib in Japanese Adults With Severe Alopecia Areata","A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Deuruxolitinib in Adult Patients With Severe Alopecia Areata With an Open-Label Extension Period","THRIVE-AAJP","Inclusion Criteria:\n\n* Written informed consent has been obtained.\n* Japanese subjects with severe alopecia areata who are between 18 and 65 years of age, inclusive, at the time of informed consent.\n* Definitive diagnosis of alopecia areata with a current episode of scalp hair loss lasting at least 6 months.\n* SALT score of 50 or more at both Screening and Baseline.\n\nExclusion Criteria:\n\n* Treatment with systemic immunosuppressive medications or agents, including Janus kinase inhibitors, within 4 months prior to randomization.\n* Treatment with biologics within 6 months prior to Screening.\n* Positive test results for hepatitis B virus, hepatitis C virus, or human immunodeficiency virus at Screening.\n* History of active tuberculosis, a positive interferon gamma release assay at Screening, or evidence of tuberculosis-related lesions on chest radiography.\n* Clinically significant hematologic abnormalities, hepatic impairment, or renal impairment at Screening.","ALL","18 Years","65 Years",{"count":199,"type":200},78,"ESTIMATED","INTERVENTIONAL",[203],"PHASE3","This study evaluates the efficacy and safety of deuruxolitinib in Japanese Adults between 18 and 65 years of age who have 50% or greater scalp hair loss.",[206],"Alopecia Areata",[208,209,210,211,212],"alopecia areata","severe alopecia areata","hair loss","deuruxolitinib","JAK inhibitor","2026-06-30",{"date":215,"type":216},"2026-07-02","ACTUAL",{"date":218,"type":216},"2026-06-19",{"date":220,"type":200},"2028-09",{"name":5,"class":6},18]