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Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy","Warsaw","02781",{"type":58,"coordinates":652},[653,654],21.01178,52.22977,{"lat":654,"lon":653},{"facility":657,"status":52,"city":658,"state":30,"zip":659,"country":660,"cosmosGeoPoint":661,"geoPoint":665,"contacts":30},"Hospital Universitari Vall d'Hebron","Barcelona","08035","Spain",{"type":58,"coordinates":662},[663,664],2.15899,41.38879,{"lat":664,"lon":663},{"facility":667,"status":52,"city":658,"state":30,"zip":668,"country":660,"cosmosGeoPoint":669,"geoPoint":671,"contacts":30},"Hospital Clinico de Barcelona","08036",{"type":58,"coordinates":670},[663,664],{"lat":664,"lon":663},{"facility":673,"status":52,"city":674,"state":30,"zip":675,"country":660,"cosmosGeoPoint":676,"geoPoint":680,"contacts":30},"Hospital General Universitario Gregorio Marañon","Madrid","28007",{"type":58,"coordinates":677},[678,679],-3.70256,40.4165,{"lat":679,"lon":678},{"facility":682,"status":52,"city":674,"state":30,"zip":683,"country":660,"cosmosGeoPoint":684,"geoPoint":686,"contacts":30},"Hospital Universitario Ramon y Cajal","28034",{"type":58,"coordinates":685},[678,679],{"lat":679,"lon":678},{"facility":688,"status":52,"city":689,"state":30,"zip":690,"country":660,"cosmosGeoPoint":691,"geoPoint":695,"contacts":30},"Hospital Regional Universitario de Malaga","Málaga","29010",{"type":58,"coordinates":692},[693,694],-4.42034,36.72016,{"lat":694,"lon":693},{"facility":697,"status":52,"city":698,"state":30,"zip":699,"country":660,"cosmosGeoPoint":700,"geoPoint":704,"contacts":30},"Hospital General Universitario de Valencia","Valencia","46014",{"type":58,"coordinates":701},[702,703],-0.37966,39.47391,{"lat":703,"lon":702},{"facility":706,"status":52,"city":707,"state":30,"zip":708,"country":709,"cosmosGeoPoint":710,"geoPoint":714,"contacts":30},"Kantonsspital St. Gallen","Sankt Gallen","9000","Switzerland",{"type":58,"coordinates":711},[712,713],9.37477,47.42391,{"lat":713,"lon":712},{"facility":716,"status":52,"city":717,"state":30,"zip":718,"country":709,"cosmosGeoPoint":719,"geoPoint":723,"contacts":30},"Universitaetsspital Zurich","Zurich","8058",{"type":58,"coordinates":720},[721,722],8.55,47.36667,{"lat":722,"lon":721},{"facility":725,"status":52,"city":726,"state":727,"zip":728,"country":729,"cosmosGeoPoint":730,"geoPoint":734,"contacts":30},"Addenbrooke's Hospital","Cambridge","Cambridgeshire","CB2 0QQ","United Kingdom",{"type":58,"coordinates":731},[732,733],0.11667,52.2,{"lat":733,"lon":732},{"facility":736,"status":52,"city":737,"state":738,"zip":739,"country":729,"cosmosGeoPoint":740,"geoPoint":744,"contacts":30},"The Christie NHS Foundation Trust","Manchester","England","M20 4BX",{"type":58,"coordinates":741},[742,743],-2.23743,53.48095,{"lat":743,"lon":742},{"facility":746,"status":52,"city":747,"state":748,"zip":749,"country":729,"cosmosGeoPoint":750,"geoPoint":754,"contacts":30},"Queen Elizabeth Hospital","Birmingham","West Midlands","B15 2TH",{"type":58,"coordinates":751},[752,753],-1.89983,52.48142,{"lat":753,"lon":752},{"facility":756,"status":52,"city":757,"state":30,"zip":758,"country":729,"cosmosGeoPoint":759,"geoPoint":763,"contacts":30},"Leeds General Infirmary","Leeds","LS1 3EX",{"type":58,"coordinates":760},[761,762],-1.54785,53.79648,{"lat":762,"lon":761},{"facility":765,"status":52,"city":766,"state":30,"zip":767,"country":729,"cosmosGeoPoint":768,"geoPoint":772,"contacts":30},"Guys & St Thomas' NHS Foundation Trust","London","SE1 9RT",{"type":58,"coordinates":769},[770,771],-0.12574,51.50853,{"lat":771,"lon":770},{"facility":774,"status":52,"city":766,"state":30,"zip":767,"country":729,"cosmosGeoPoint":775,"geoPoint":777,"contacts":30},"Sarah Cannon Research Institute UK",{"type":58,"coordinates":776},[770,771],{"lat":771,"lon":770},{"facility":779,"status":52,"city":766,"state":30,"zip":780,"country":729,"cosmosGeoPoint":781,"geoPoint":783,"contacts":30},"Royal Marsden Hospital - Chelsea","SW3 6JJ",{"type":58,"coordinates":782},[770,771],{"lat":771,"lon":770},{"facility":785,"status":52,"city":786,"state":30,"zip":787,"country":729,"cosmosGeoPoint":788,"geoPoint":792,"contacts":30},"Mount Vernon Cancer Center","Middlesex","HA6 2RN",{"type":58,"coordinates":789},[790,791],-0.26856,51.53174,{"lat":791,"lon":790},{"facility":794,"status":52,"city":795,"state":30,"zip":796,"country":729,"cosmosGeoPoint":797,"geoPoint":801,"contacts":30},"Royal Marsden Hospital - Sutton","Sutton","SM2 5PT",{"type":58,"coordinates":798},[799,800],-0.2,51.35,{"lat":800,"lon":799},{"type":803,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100481461",false,"NCT05549297","Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)","Phase 2\u002F3 Randomized Study of Tebentafusp as Monotherapy and in Combination With Pembrolizumab Versus Investigator's Choice in HLA-A*02:01-positive Participants With Previously Treated Advanced Melanoma (TEBE-AM)","Inclusion Criteria:\n\n* HLA-A\\*02:01-positive\n* unresectable Stage III or Stage IV non-ocular melanoma\n* archival tumor tissue sample or a newly obtained biopsy of a tumor lesion not previously irradiated has been provided.\n* measurable or non-measurable disease per RECIST 1.1\n* Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1\n* If applicable, must agree to use highly effective contraception\n* Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the Informed Consent (ICF) and protocol\n* Must agree to provide protocol specified samples for biomarker analyses.\n\nExclusion Criteria:\n\n* Pregnant or lactating women\n* diagnosis of ocular or metastatic uveal melanoma\n* history of a malignant disease other than those being treated in this study\n* ineligible to be retreated with pembrolizumab due to a treatment-related AE\n* known untreated or symptomatic central nervous system (CNS) metastases and\u002For carcinomatous meningitis\n* previous severe hypersensitivity reaction to treatment with another monoclonal antibody (mAb)\n* active autoimmune disease requiring immunosuppressive treatment\n* known psychiatric or substance abuse disorders\n* received prior treatment with a licensed or investigative Immune-mobilizing monoclonal T-cell receptor Against Cancer (ImmTAC) medication or who have not completed adequate washout from prior medications.\n* received chemotherapy or biological cancer therapy (excluding anti-PD(L)1 mAb, ipilimumab, and BRAF TKI regimen) within 14 days of first dose\n* received cellular therapies within 90 days of study intervention\n* ongoing Common Terminology Criteria for Adverse Events(CTCAE) Grade ≥ 2 clinically significant who in the opinion of the investigator could affect the outcome of the study\n* received systemic treatment with steroids or any other immunosuppressive drug within 2 weeks of first dose\n* have not progressed on treatment with an anti-PD(L)1 mAb\n* have not received prior treatment with an approved anti-CTLA-4 mAb\n* have a BRAF V600 mutation, who have not received a prior BRAF\u002FMEK TKI regimen\n* currently participating or have participated in a study of an investigational agent or using an investigational device within 30 days of the first dose\n* known history of chronic viral infections such as hepatitis B virus (HBV) or hepatitis C virus (HCV)\n* known clinically significant pulmonary or cardiac disease or impaired lung or cardiac function\n* Out of range Laboratory values\n* history of allogenic tissue\u002Fsolid organ transplant","ALL","18 Years",{"count":813,"type":814},540,"ESTIMATED","INTERVENTIONAL",[817],"PHASE3","The purpose of this study is to evaluate the efficacy and safety of tebentafusp-based regimens, including tebentafusp monotherapy and in combination with anti-PD1 vs investigator choice (including clinical trials of investigational agents, salvage therapy per local standard of care \\[SoC\\], best supportive care \\[BSC\\] on protocol survivor follow up) in patients with advanced non-ocular melanoma.",[820],"Advanced Melanoma",[822,823,27,824,825,826,827,828,829,830,831,832,833,834,835,836,837],"Melanoma","IMCgp100","Cutaneous Melanoma","Immunotherapy","gp100","TCR","Pembrolizumab","Bispecific T cell receptor fusion protein","ImmTAC (Immune-mobilizing monoclonal T-cell receptor Against Cancer)","Immune mobilizing monoclonal T cell receptor against cancer","KIMMTRAK","Acral Melanoma","Mucosal Melanoma","Blue Nevus","anti-PDL1","checkpoint therapy","2026-02-23",{"date":840,"type":841},"2026-02-25","ACTUAL",{"date":843,"type":841},"2022-12-19",{"date":845,"type":814},"2028-07",{"name":5,"class":6},82]