The Efficiency of Surgery and Radiotherapy After SHR-1316 (Adebrelimab) and Platinum-containing Doublet Induction Therapy for Limited-stage Small Cell Lung Cancer

Trial statusNot yet recruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18-70
SponsorShanghai Pulmonary Hospital, Shanghai, China

About this trial

To compare the efficiency between surgery and radiotherapy after SHR-1316 (Adebrelimab)and platinum-containing doublet induction therapy for limited-stage small cell lung cancer

Eligibility criteria

Qualifiers

after signing informed consent;

Aged 18-70;

Histologically or cytologically confirmed SCLC, imaging examination and other confirmed limited-stage small cell lung cancer, and without previous treatment;

For clinical stage IIB-III, all patients should have clear lymph node pathology by EBUS to exclud occult lymph node metastasis.

Disqualifiers

Received any systemic anticancer therapy, including surgery, local radiotherapy, cytotoxic drug therapy, targeted drug therapy, and experimental therapy;

Patients with other malignancies within five years prior to the start of the trial;

Combined with unstable systemic diseases, such as uncontrolled hypertension, severe arrhythmia, etc;

With active, known or suspected autoimmune disease, or autoimmune paraneoplastic syndrome requiring systemic therapy;

Trial design

Treatments tested in this trial

  • chemotherapy and SHR-1316(Adebrelimab) comnined with surgery or radiotherapy

Treatment groups

348 Participants
are divided into 2 treatment groups

Locations

1
Shanghai Pulmonary Hospital200433, Shang'aiShanghai Municipality, China

Sponsors and collaborators

Shanghai Pulmonary Hospital, Shanghai, China

Lead sponsor

Jiangsu HengRui Medicine Co., Ltd.

Collaborator