[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555582":3},{"organization":4,"outcomesModule":7,"designInfo":64,"detailedDescription":71,"studyPopulation":67,"armGroups":72,"interventions":88,"overallOfficials":124,"centralContacts":67,"locations":128,"responsibleParty":2589,"collaborators":67,"id":2591,"slug":67,"hasResults":2592,"nctId":2593,"briefTitle":2594,"officialTitle":2595,"acronym":67,"eligibilityCriteria":2596,"healthyVolunteers":2592,"sex":2597,"minAge":67,"maxAge":2598,"enrollmentInfo":2599,"targetDuration":67,"studyType":2602,"phases":2603,"briefSummary":2605,"conditions":2606,"keywords":67,"overallStatus":131,"whyStopped":67,"lastUpdateSubmitDate":2609,"lastUpdatePostDateStruct":2610,"startDateStruct":2613,"completionDateStruct":2615,"leadSponsor":2617,"locationsCount":2618},{"fullName":5,"class":6},"Children's Oncology Group","NETWORK",{"primaryOutcomes":8,"secondaryOutcomes":20,"otherOutcomes":57},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Number of enrollments of newly diagnosed AYA female cancer patients age \u003C 40 years","Number of enrollments by the end of the DOD funded grant period, and ideally prior to Year 4 to enable greater duration of follow-up time. Will help determine if a larger efficacy study can be successfully completed as a cross network trial in a reasonable funding period.","Up to 2 years post-chemotherapy",{"measure":14,"description":15,"timeFrame":12},"Accrual rates of newly diagnosed AYA female cancer patients age \u003C 40 years","Accrual rates of newly diagnosed AYA female cancer patients age \\\u003C 40 years. Over the second half of the funding period, demonstrate a positive trajectory in accrual rates that provides data to inform future funding proposals that would seek to complete the overall larger study within a typical 5-year funding period.",{"measure":17,"description":18,"timeFrame":19},"Anti-mullerian hormone (AMH) levels","AMH values will be examined to confirm that the combined variability of AMH in both arms is consistent with our a priori assumptions.","At 2 years post-chemotherapy",[21,24,27,30,33,36,39,42,45,48,51,54],{"measure":22,"description":23,"timeFrame":12},"Longitudinal AMH along with other ovarian hormone levels","These measurements will help inform rates of missingness. Will be used to estimate the longitudinal trajectory of change in these hormones by triptorelin randomization status.",{"measure":25,"description":26,"timeFrame":12},"Estrogen deprivation symptoms: Hot flashes","Estrogen deprivation symptoms include hot flashes. The Patient-Reported Outcomes version of the Common Terminology for Adverse Events (PRO-CTCAE) will be used to collect information on the frequency and interference of hot flashes.",{"measure":28,"description":29,"timeFrame":12},"Estrogen deprivation symptoms: Headaches","Estrogen deprivation symptoms include headaches. The Patient-Reported Outcomes version of the Common Terminology for Adverse Events (PRO-CTCAE) will be used to collect information on the frequency and interference of headaches.",{"measure":31,"description":32,"timeFrame":12},"Estrogen deprivation symptoms: Vaginal\u002Fvulvar symptoms","Estrogen deprivation symptoms include vaginal\u002Fvulvar symptoms. The Patient-Reported Outcomes version of the Common Terminology for Adverse Events (PRO-CTCAE) will be used to collect information on the frequency and interference of vaginal\u002Fvulvar symptoms. The PROMIS Sexual Function and Satisfaction version (v) 2.0 Brief Profile - Female (PROMIS SexFS) will be used to evaluate vaginal and vulvar discomfort, pain, and lubrication.",{"measure":34,"description":35,"timeFrame":12},"Estrogen deprivation symptoms: Sexual function","Estrogen deprivation symptoms include sexual function. The Patient-Reported Outcomes version of the Common Terminology for Adverse Events (PRO-CTCAE) will be used to collect information on the frequency and interference of sexual function. The PROMIS Sexual Function and Satisfaction version (v) 2.0 Brief Profile - Female (PROMIS SexFS) will be used to evaluate sexual activity, desire, and satisfaction among all participants.",{"measure":37,"description":38,"timeFrame":12},"Sexual Health","Sexual dysfunction will be assessed using PROMIS SexFS.",{"measure":40,"description":41,"timeFrame":12},"Menstrual patterns","Menstrual patterns will be assessed using standard items and characterized according to the Staging of Reproductive Aging Workshop criteria.",{"measure":43,"description":44,"timeFrame":12},"Global health-related quality of life: Anxiety","Global health-related quality of life will be assessed using the PROMIS 29 Profile v2.1, which includes assessment of anxiety. For adolescent participants, the PROMIS Pediatric Profile-25 v2.0 will be used to measure health domains.",{"measure":46,"description":47,"timeFrame":12},"Global health-related quality of life: Fatigue","Global health-related quality of life will be assessed using the PROMIS 29 Profile v2.1, which includes assessment of fatigue. For adolescent participants, the PROMIS Pediatric Profile-25 v2.0 will be used to measure health domains.",{"measure":49,"description":50,"timeFrame":12},"Global health-related quality of life: Depression","Global health-related quality of life will be assessed using the PROMIS 29 Profile v2.1, which includes assessment of depression. For adolescent participants, the PROMIS Pediatric Profile-25 v2.0 will be used to measure health domains.",{"measure":52,"description":53,"timeFrame":12},"Global health-related quality of life: Sleep disturbance","Global health-related quality of life will be assessed using the PROMIS 29 Profile v2.1, which includes assessment of sleep disturbance. For adolescent participants, the PROMIS Pediatric Profile-25 v2.0 will be used to measure health domains, with the addition of the PROMIS Pediatric Sleep Disturbance 4a scale.",{"measure":55,"description":56,"timeFrame":12},"Global health-related quality of life: Participation in social activities","Global health-related quality of life will be assessed using the PROMIS 29 Profile v2.1, which includes assessment of participation in social activities. For adolescent participants, the PROMIS Pediatric Profile-25 v2.0 will be used to measure health domains.",[58,61],{"measure":59,"description":60,"timeFrame":12},"Reproductive concerns","The reproductive concerns after cancer scale will be used for fertility potential and acceptance.",{"measure":62,"description":63,"timeFrame":12},"Reproductive outcomes","Reproductive outcomes will be assessed using selected questions from the US Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey's (NHANES) Reproductive Health module.",{"allocation":65,"interventionModel":66,"interventionModelDescription":67,"primaryPurpose":68,"observationalModel":67,"timePerspective":67,"maskingInfo":69},"RANDOMIZED","PARALLEL",null,"PREVENTION",{"masking":70,"maskingDescription":67,"whoMasked":67},"NONE","PRIMARY OBJECTIVES:\n\nI. Determine the feasibility of conducting a cross network, multi-site, randomized clinical trial of triptorelin among newly diagnosed adolescent and young adult (AYA) female cancer patients age \\\u003C 40 years (exclusive of breast cancer).\n\nII. Measure ovarian reserve via anti-Mullerian hormone (AMH) at 2-years post completion of alkylating agent-containing chemotherapy among randomized patients.\n\nSECONDARY OBJECTIVES:\n\nI. Collect information on the longitudinal trajectory of change in AMH and other ovarian hormone levels from cancer diagnosis to 2 years post cancer treatment completion among randomized patients.\n\nII. Determine the feasibility of measuring estrogen deprivation symptoms (i.e., hot flashes, sexual dysfunction) menstrual pattern, and quality of life among randomized patients.\n\nEXPLORATORY OBJECTIVE:\n\nI. Establish a unique cohort of female AYA patients treated with alkylating agent chemotherapy and randomized to receive or not receive triptorelin, that can be followed long-term to study reproductive health concerns and outcomes as well as genetic risk factors for premature menopause.\n\nOUTLINE: Patients are randomized to 1 of 2 arms.\n\nARM A: Patients receive triptorelin intramuscularly (IM) up to 14 days prior to standard chemotherapy. For patients whose chemotherapy exceeds 24 weeks, a second dose of triptorelin may be given 24 weeks after the first dose at the treating physician's discretion. Patients also undergo blood sample collection throughout the study.\n\nARM B: Patients receive standard chemotherapy. Patients also undergo blood sample collection throughout the study.\n\nAfter completion of study treatment, patients are followed up at 1 and 2 years.",[73,82],{"label":74,"type":75,"description":76,"interventionNames":77},"Arm A (triptorelin)","EXPERIMENTAL","Patients receive triptorelin IM up to 14 days prior to standard chemotherapy. For patients whose chemotherapy exceeds 24 weeks, a second dose of triptorelin may be given 24 weeks after the first dose at the treating physician's discretion. Patients also undergo blood sample collection throughout the study.",[78,79,80,81],"Procedure: Biospecimen Collection","Other: Electronic Health Record Review","Other: Survey Administration","Drug: Triptorelin Pamoate",{"label":83,"type":84,"description":85,"interventionNames":86},"Arm B (usual care)","ACTIVE_COMPARATOR","Patients receive standard chemotherapy. Patients also undergo blood sample collection throughout the study.",[87,78,79,80],"Other: Best Practice",[89,97,106,110,113],{"type":90,"name":91,"description":92,"armGroupLabels":93,"otherNames":94},"OTHER","Best Practice","Receive standard chemotherapy",[83],[95,96],"standard of care","standard therapy",{"type":98,"name":99,"description":100,"armGroupLabels":101,"otherNames":102},"PROCEDURE","Biospecimen Collection","Undergo blood sample collection",[74,83],[103,104,105],"Biological Sample Collection","Biospecimen Collected","Specimen Collection",{"type":90,"name":107,"description":108,"armGroupLabels":109,"otherNames":67},"Electronic Health Record Review","Ancillary studies",[74,83],{"type":90,"name":111,"description":108,"armGroupLabels":112,"otherNames":67},"Survey Administration",[74,83],{"type":114,"name":115,"description":116,"armGroupLabels":117,"otherNames":118},"DRUG","Triptorelin Pamoate","Given IM",[74],[119,120,121,122,123],"Decapeptyl","Diphereline","Pamorelin","Trelstar","Triptorelin Embonate",[125],{"name":126,"affiliation":5,"role":127},"Eric J Chow","PRINCIPAL_INVESTIGATOR",[129,151,161,175,190,205,219,230,246,261,275,289,304,319,333,343,354,370,385,400,416,428,442,450,459,471,483,495,511,527,542,557,569,583,594,605,620,629,643,658,665,679,695,710,724,732,741,755,766,775,784,793,807,822,830,844,856,871,886,895,904,913,929,939,954,968,981,989,1001,1016,1025,1033,1043,1051,1059,1073,1087,1099,1111,1123,1132,1147,1159,1175,1190,1202,1218,1226,1241,1255,1270,1275,1290,1302,1310,1318,1330,1338,1348,1357,1369,1381,1393,1405,1417,1425,1437,1449,1465,1476,1491,1505,1517,1530,1542,1556,1568,1582,1592,1607,1621,1634,1644,1657,1668,1677,1689,1698,1709,1718,1727,1736,1749,1764,1775,1790,1806,1817,1832,1846,1857,1871,1885,1900,1916,1930,1944,1960,1975,1990,2005,2019,2035,2045,2061,2074,2088,2103,2114,2129,2144,2160,2176,2192,2206,2217,2232,2244,2254,2269,2284,2299,2310,2325,2341,2356,2370,2381,2390,2405,2420,2436,2446,2461,2470,2485,2496,2508,2520,2528,2540,2558,2574],{"facility":130,"status":131,"city":132,"state":133,"zip":134,"country":135,"countryCode":136,"cosmosGeoPoint":137,"geoPoint":142,"contacts":143},"Children's Hospital of Alabama","RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":138,"coordinates":139},"Point",[140,141],-86.80249,33.52066,{"lat":141,"lon":140},[144,149],{"name":145,"role":146,"phone":147,"phoneExt":67,"email":148},"Site Public Contact","CONTACT","205-638-9285","oncologyresearch@peds.uab.edu",{"name":150,"role":127,"phone":67,"phoneExt":67,"email":67},"Jamie M. Aye",{"facility":152,"status":131,"city":132,"state":133,"zip":134,"country":135,"countryCode":136,"cosmosGeoPoint":153,"geoPoint":155,"contacts":156},"University of Alabama at Birmingham Cancer Center",{"type":138,"coordinates":154},[140,141],{"lat":141,"lon":140},[157,159],{"name":145,"role":146,"phone":67,"phoneExt":67,"email":158},"gingerreeves@uabmc.edu",{"name":160,"role":127,"phone":67,"phoneExt":67,"email":67},"Vanessa Eulo",{"facility":162,"status":131,"city":163,"state":133,"zip":164,"country":135,"countryCode":136,"cosmosGeoPoint":165,"geoPoint":169,"contacts":170},"USA Health Strada Patient Care Center","Mobile","36604",{"type":138,"coordinates":166},[167,168],-88.04305,30.69436,{"lat":168,"lon":167},[171,173],{"name":145,"role":146,"phone":172,"phoneExt":67,"email":67},"800-388-8721",{"name":174,"role":127,"phone":67,"phoneExt":67,"email":67},"Hamayun Imran",{"facility":176,"status":131,"city":177,"state":178,"zip":179,"country":135,"countryCode":136,"cosmosGeoPoint":180,"geoPoint":184,"contacts":185},"Phoenix Childrens Hospital","Phoenix","Arizona","85016",{"type":138,"coordinates":181},[182,183],-112.07404,33.44838,{"lat":183,"lon":182},[186,188],{"name":145,"role":146,"phone":187,"phoneExt":67,"email":67},"602-546-0920",{"name":189,"role":127,"phone":67,"phoneExt":67,"email":67},"Alexandra M. Walsh",{"facility":191,"status":131,"city":192,"state":193,"zip":194,"country":135,"countryCode":136,"cosmosGeoPoint":195,"geoPoint":199,"contacts":200},"Mercy Hospital Fort Smith","Fort Smith","Arkansas","72903",{"type":138,"coordinates":196},[197,198],-94.39855,35.38592,{"lat":198,"lon":197},[201,203],{"name":145,"role":146,"phone":202,"phoneExt":67,"email":67},"800-378-9373",{"name":204,"role":127,"phone":67,"phoneExt":67,"email":67},"Jay W. Carlson",{"facility":206,"status":131,"city":207,"state":193,"zip":208,"country":135,"countryCode":136,"cosmosGeoPoint":209,"geoPoint":213,"contacts":214},"Arkansas Children's Hospital","Little Rock","72202-3591",{"type":138,"coordinates":210},[211,212],-92.28959,34.74648,{"lat":212,"lon":211},[215,217],{"name":145,"role":146,"phone":216,"phoneExt":67,"email":67},"501-364-7373",{"name":218,"role":127,"phone":67,"phoneExt":67,"email":67},"Michael W. Bishop",{"facility":220,"status":131,"city":207,"state":193,"zip":221,"country":135,"countryCode":136,"cosmosGeoPoint":222,"geoPoint":224,"contacts":225},"CARTI Cancer Center","72205",{"type":138,"coordinates":223},[211,212],{"lat":212,"lon":211},[226,229],{"name":145,"role":146,"phone":227,"phoneExt":67,"email":228},"501-906-4199","Research@CARTI.com",{"name":204,"role":127,"phone":67,"phoneExt":67,"email":67},{"facility":231,"status":131,"city":232,"state":233,"zip":234,"country":135,"countryCode":136,"cosmosGeoPoint":235,"geoPoint":239,"contacts":240},"City of Hope Comprehensive Cancer Center","Duarte","California","91010",{"type":138,"coordinates":236},[237,238],-117.97729,34.13945,{"lat":238,"lon":237},[241,244],{"name":145,"role":146,"phone":242,"phoneExt":67,"email":243},"800-826-4673","becomingapatient@coh.org",{"name":245,"role":127,"phone":67,"phoneExt":67,"email":67},"Rusha Bhandari",{"facility":247,"status":131,"city":248,"state":233,"zip":249,"country":135,"countryCode":136,"cosmosGeoPoint":250,"geoPoint":254,"contacts":255},"UC San Diego Moores Cancer Center","La Jolla","92093",{"type":138,"coordinates":251},[252,253],-117.2742,32.84727,{"lat":253,"lon":252},[256,259],{"name":145,"role":146,"phone":257,"phoneExt":67,"email":258},"858-822-5354","cancercto@ucsd.edu",{"name":260,"role":127,"phone":67,"phoneExt":67,"email":67},"H. I. Su",{"facility":262,"status":131,"city":263,"state":233,"zip":264,"country":135,"countryCode":136,"cosmosGeoPoint":265,"geoPoint":269,"contacts":270},"Loma Linda University Medical Center","Loma Linda","92354",{"type":138,"coordinates":266},[267,268],-117.26115,34.04835,{"lat":268,"lon":267},[271,273],{"name":145,"role":146,"phone":272,"phoneExt":67,"email":67},"909-558-4050",{"name":274,"role":127,"phone":67,"phoneExt":67,"email":67},"Albert Kheradpour",{"facility":276,"status":131,"city":277,"state":233,"zip":278,"country":135,"countryCode":136,"cosmosGeoPoint":279,"geoPoint":283,"contacts":284},"Mattel Children's Hospital UCLA","Los Angeles","90095",{"type":138,"coordinates":280},[281,282],-118.24368,34.05223,{"lat":282,"lon":281},[285,287],{"name":145,"role":146,"phone":286,"phoneExt":67,"email":67},"310-825-6708",{"name":288,"role":127,"phone":67,"phoneExt":67,"email":67},"Satiro N. De Oliveira",{"facility":290,"status":131,"city":291,"state":233,"zip":292,"country":135,"countryCode":136,"cosmosGeoPoint":293,"geoPoint":297,"contacts":298},"Kaiser Permanente-Oakland","Oakland","94611",{"type":138,"coordinates":294},[295,296],-122.2708,37.80437,{"lat":296,"lon":295},[299,302],{"name":145,"role":146,"phone":300,"phoneExt":67,"email":301},"877-642-4691","Kpoct@kp.org",{"name":303,"role":127,"phone":67,"phoneExt":67,"email":67},"Aarati V. Rao",{"facility":305,"status":131,"city":306,"state":233,"zip":307,"country":135,"countryCode":136,"cosmosGeoPoint":308,"geoPoint":312,"contacts":313},"Children's Hospital of Orange County","Orange","92868",{"type":138,"coordinates":309},[310,311],-117.85311,33.78779,{"lat":311,"lon":310},[314,317],{"name":145,"role":146,"phone":315,"phoneExt":67,"email":316},"714-509-8646","oncresearch@choc.org",{"name":318,"role":127,"phone":67,"phoneExt":67,"email":67},"Elyssa M. Rubin",{"facility":320,"status":131,"city":321,"state":233,"zip":322,"country":135,"countryCode":136,"cosmosGeoPoint":323,"geoPoint":327,"contacts":328},"Sutter Medical Center Sacramento","Sacramento","95816",{"type":138,"coordinates":324},[325,326],-121.4944,38.58157,{"lat":326,"lon":325},[329,331],{"name":145,"role":146,"phone":67,"phoneExt":67,"email":330},"clinicalresearch@sutterhealth.org",{"name":332,"role":127,"phone":67,"phoneExt":67,"email":67},"Sandra Baril",{"facility":334,"status":335,"city":336,"state":233,"zip":337,"country":135,"countryCode":136,"cosmosGeoPoint":338,"geoPoint":342,"contacts":67},"UC San Diego Medical Center - Hillcrest","SUSPENDED","San Diego","92103",{"type":138,"coordinates":339},[340,341],-117.16472,32.71571,{"lat":341,"lon":340},{"facility":344,"status":131,"city":336,"state":233,"zip":345,"country":135,"countryCode":136,"cosmosGeoPoint":346,"geoPoint":348,"contacts":349},"Rady Children's Hospital - San Diego","92123",{"type":138,"coordinates":347},[340,341],{"lat":341,"lon":340},[350,352],{"name":145,"role":146,"phone":351,"phoneExt":67,"email":67},"858-966-5934",{"name":353,"role":127,"phone":67,"phoneExt":67,"email":67},"William D. Roberts",{"facility":355,"status":131,"city":356,"state":357,"zip":358,"country":135,"countryCode":136,"cosmosGeoPoint":359,"geoPoint":363,"contacts":364},"Children's Hospital Colorado","Aurora","Colorado","80045",{"type":138,"coordinates":360},[361,362],-104.83192,39.72943,{"lat":362,"lon":361},[365,368],{"name":145,"role":146,"phone":366,"phoneExt":67,"email":367},"303-764-5056","josh.b.gordon@nsmtp.kp.org",{"name":369,"role":127,"phone":67,"phoneExt":67,"email":67},"Jenna M. Demedis",{"facility":371,"status":131,"city":372,"state":357,"zip":373,"country":135,"countryCode":136,"cosmosGeoPoint":374,"geoPoint":378,"contacts":379},"Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center","Denver","80218",{"type":138,"coordinates":375},[376,377],-104.9847,39.73915,{"lat":377,"lon":376},[380,383],{"name":145,"role":146,"phone":381,"phoneExt":67,"email":382},"303-832-2344","PSGResearchSharedMailbox@HCAHealthcare.com",{"name":384,"role":127,"phone":67,"phoneExt":67,"email":67},"Florence Choo",{"facility":386,"status":131,"city":387,"state":388,"zip":389,"country":135,"countryCode":136,"cosmosGeoPoint":390,"geoPoint":394,"contacts":395},"Connecticut Children's Medical Center","Hartford","Connecticut","06106",{"type":138,"coordinates":391},[392,393],-72.68509,41.76371,{"lat":393,"lon":392},[396,398],{"name":145,"role":146,"phone":397,"phoneExt":67,"email":67},"860-545-9981",{"name":399,"role":127,"phone":67,"phoneExt":67,"email":67},"Michael S. Isakoff",{"facility":401,"status":131,"city":402,"state":403,"zip":404,"country":135,"countryCode":136,"cosmosGeoPoint":405,"geoPoint":409,"contacts":410},"Beebe Medical Center","Lewes","Delaware","19958",{"type":138,"coordinates":406},[407,408],-75.13935,38.77456,{"lat":408,"lon":407},[411,414],{"name":145,"role":146,"phone":412,"phoneExt":67,"email":413},"302-291-6730","research@beebehealthcare.org",{"name":415,"role":127,"phone":67,"phoneExt":67,"email":67},"Gregory A. 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Villeneuve",{"facility":2559,"status":131,"city":2560,"state":2561,"zip":2562,"country":2545,"countryCode":2546,"cosmosGeoPoint":2563,"geoPoint":2567,"contacts":2568},"The Montreal Children's Hospital of the MUHC","Montreal","Quebec","H3H 1P3",{"type":138,"coordinates":2564},[2565,2566],-73.58781,45.50884,{"lat":2566,"lon":2565},[2569,2572],{"name":145,"role":146,"phone":2570,"phoneExt":67,"email":2571},"514-412-4445","info@thechildren.com",{"name":2573,"role":127,"phone":67,"phoneExt":67,"email":67},"Stephanie Mourad",{"facility":2575,"status":131,"city":2576,"state":67,"zip":2577,"country":2545,"countryCode":2546,"cosmosGeoPoint":2578,"geoPoint":2582,"contacts":2583},"CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)","Québec","G1V 4G2",{"type":138,"coordinates":2579},[2580,2581],-71.21454,46.81228,{"lat":2581,"lon":2580},[2584,2587],{"name":145,"role":146,"phone":2585,"phoneExt":67,"email":2586},"418-525-4444","rechclinique@crchudequebec.ulaval.ca",{"name":2588,"role":127,"phone":67,"phoneExt":67,"email":67},"Bruno Michon",{"type":2590,"investigatorFullName":67,"investigatorTitle":67,"investigatorAffiliation":67,"oldNameTitle":67,"oldOrganization":67},"SPONSOR","100555582",false,"NCT06513962","Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer","Triptorelin and Protection of Ovarian Reserve in Adolescents and Young Adults With Cancer","Inclusion Criteria:\n\n* \\\u003C 40 years of age at the time of enrollment\n* Patient must be a post-menarchal female and report that their initial menstrual period occurred \\> 6 months prior to enrollment. (Current menstrual status is not part of the inclusion criteria.)\n* Newly diagnosed with first cancer, exclusive of breast cancer.\n\n  * Note: Apart from breast carcinoma, other tumor types originating in the breast are permitted (e.g., sarcoma, lymphoma).\n* Planned treatment must include one or more of the following alkylating agents delivered with curative intent: cyclophosphamide, ifosfamide, procarbazine, chlorambucil, carmustine (BCNU), lomustine (CCNU), melphalan, thiotepa, busulfan, nitrogen mustard.\n* For patients \\\u003C 20 years of age at enrollment, the expected alkylator dose must be ≥ 4 g\u002Fm\\^2 cumulative cyclophosphamide equivalent dose (CED). For patients ≥ 20 years of age at enrollment, any planned alkylator dose is permitted. Eligible patients must receive at least one of the alkylators that contribute to CED.\n* All patients and\u002For their parents or legal guardians must sign a written informed consent.\n* All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met.\n\nExclusion Criteria:\n\n* Any planned radiation to the pelvis; or cranial radiation ≥ 30 gray (Gy) to the hypothalamus, inclusive of any total body irradiation (TBI).\n* Planned bilateral oophorectomy. Note: A participant's desire to pursue alternative fertility preservation procedures (i.e., embryo, oocyte, or ovarian tissue cryopreservation) will be allowed (and in fact encouraged).\n* Congenital syndromes associated with infertility and decreased ovarian reserve at baseline. For example: Turner's Syndrome, Fragile X premutation carriers, Down syndrome, etc.\n* Pre-existing seizure disorder, congenital long QT syndrome, pseudotumor cerebri; history of pulmonary embolism, venous thrombosis, or myocardial infarction. Note: Contact study chairs if questions arise about other pre-existing conditions.\n* Receipt of long acting (depot) GnRH agonists within 6 months before enrollment. In contrast, subcutaneous GnRH agonist used for oocyte retrieval is not an exclusion; oral and other hormonal contraceptive use is also not an exclusion. Note: Please see protocol for the concomitant therapy restrictions for patients during the study treatment period. See protocol for information about oral and other hormonal contractive use during the study treatment period.\n* Prior receipt of systemic chemotherapy. However, steroids and intrathecal chemotherapy are permitted prior to study enrollment.\n* Any prior radiation to the pelvis; or cranial radiation ≥ 30 Gy to the hypothalamus, inclusive of any total body irradiation (TBI).\n* Patients who are pregnant are not eligible. A pregnancy test is required for female patients of childbearing potential.\n* Lactating females who plan to breastfeed their infants for the duration of triptorelin therapy (24 weeks per dose).\n* Sexually active patients of reproductive potential who have not agreed to use an effective contraceptive method for the duration of triptorelin therapy (24 weeks per dose).","FEMALE","39 Years",{"count":2600,"type":2601},60,"ESTIMATED","INTERVENTIONAL",[2604],"PHASE3","This phase III trial compares the effect of giving triptorelin vs no triptorelin in preventing ovarian damage in adolescents and young adults (AYAs) with cancer receiving chemotherapy with an alkylating agents. Alkylating agents are part of standard chemotherapy, but may cause damage to the ovaries. If the ovaries are not working well or completely shut down, then it will be difficult or impossible to get pregnant in the future. Triptorelin works by blocking certain hormones and causing the ovaries to slow down or pause normal activity. The triptorelin used in this study stays active in the body for 24 weeks or about 6 months after a dose is given. After triptorelin is cleared from the body, the ovaries resume normal activities. Adding triptorelin before the start of chemotherapy treatment may reduce the chances of damage to the ovaries.",[2607,2608],"Hematopoietic and Lymphatic System Neoplasm","Malignant Solid Neoplasm","2026-05-01",{"date":2611,"type":2612},"2026-05-05","ACTUAL",{"date":2614,"type":2612},"2025-02-27",{"date":2616,"type":2601},"2029-10-30",{"name":5,"class":6},193]