[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100565445":3},{"organization":4,"outcomesModule":7,"designInfo":40,"detailedDescription":16,"studyPopulation":16,"armGroups":47,"interventions":57,"overallOfficials":16,"centralContacts":64,"locations":74,"responsibleParty":173,"collaborators":16,"id":176,"slug":16,"hasResults":177,"nctId":178,"briefTitle":179,"officialTitle":179,"acronym":180,"eligibilityCriteria":181,"healthyVolunteers":177,"sex":182,"minAge":183,"maxAge":16,"enrollmentInfo":184,"targetDuration":16,"studyType":187,"phases":188,"briefSummary":190,"conditions":191,"keywords":16,"overallStatus":77,"whyStopped":16,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":204},{"fullName":5,"class":6},"Herlev and Gentofte Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":30},[9],{"measure":10,"description":11,"timeFrame":12},"Time to the first occurrence of any of the components of the composite: all-cause mortality, hospitalization for heart failure, hospitalization for myocardial infarction, hospitalization for ischemic stroke, and incident or worsening nephropathy.","Incident or worsening nephropathy is defined as:\n\n* A sustained decrease in estimated glomerular filtration rate (eGFR) of ≥40% from baseline\n* A sustained decrease in eGFR of ≤10 per minute per 1.73 m2\n* Initiation of dialysis\n* Kidney transplantation","Up to 24 months",[14,17,19,21,23,26,28],{"measure":15,"description":16,"timeFrame":12},"All-cause mortality",null,{"measure":18,"description":16,"timeFrame":12},"Hospitalization for heart failure",{"measure":20,"description":16,"timeFrame":12},"Hospitalization for myocardial infarction",{"measure":22,"description":16,"timeFrame":12},"Hospitalization for ischemic stroke",{"measure":24,"description":25,"timeFrame":12},"Incident or worsening nephropathy","Defined as a sustained decrease in estimated glomerular filtration rate (eGFR) of ≥40% from baseline, a sustained decrease in eGFR of ≤10 per minute per 1.73 m2, initiation of dialysis, or kidney transplantation",{"measure":27,"description":16,"timeFrame":12},"Hospitalization for coronary revascularization",{"measure":29,"description":16,"timeFrame":12},"Hospitalization for unstable angina",[31,34,36,38],{"measure":32,"description":33,"timeFrame":12},"Hospitalization for ketoacidosis","Safety outcome",{"measure":35,"description":33,"timeFrame":12},"Hospitalization for limb amputation",{"measure":37,"description":33,"timeFrame":12},"Hospitalization for genitourinary infection",{"measure":39,"description":33,"timeFrame":12},"Hospitalization for fracture",{"allocation":41,"interventionModel":42,"interventionModelDescription":16,"primaryPurpose":43,"observationalModel":16,"timePerspective":16,"maskingInfo":44},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":45,"maskingDescription":46,"whoMasked":16},"NONE","Treatment assignment will be blinded to the statistician analysing the trial data.",[48,53],{"label":49,"type":6,"description":50,"interventionNames":51},"Empagliflozin 10 MG","Head-to-head comparator",[52],"Drug: Empagliflozin 10 MG",{"label":54,"type":6,"description":50,"interventionNames":55},"Dapagliflozin 10 MG",[56],"Drug: Dapagliflozin 10 MG",[58,62],{"type":59,"name":49,"description":60,"armGroupLabels":61,"otherNames":16},"DRUG","Once daily",[49],{"type":59,"name":54,"description":60,"armGroupLabels":63,"otherNames":16},[54],[65,70],{"name":66,"role":67,"phone":68,"phoneExt":16,"email":69},"Morten Schou, Professor","CONTACT","004540523920","morten.schou.04@regionh.dk",{"name":71,"role":67,"phone":72,"phoneExt":16,"email":73},"Daniel M. Christensen, MD, PhD","004526248546","dmc@dadlnet.dk",[75,87,92,105,110,118,126,134,142,150,157,165],{"facility":76,"status":77,"city":78,"state":16,"zip":16,"country":79,"countryCode":80,"cosmosGeoPoint":81,"geoPoint":86,"contacts":16},"Bispebjerg Hospital","RECRUITING","Copenhagen","Denmark","DK",{"type":82,"coordinates":83},"Point",[84,85],12.56553,55.67594,{"lat":85,"lon":84},{"facility":88,"status":77,"city":78,"state":16,"zip":16,"country":79,"countryCode":80,"cosmosGeoPoint":89,"geoPoint":91,"contacts":16},"Rigshospitalet",{"type":82,"coordinates":90},[84,85],{"lat":85,"lon":84},{"facility":5,"status":77,"city":93,"state":16,"zip":16,"country":79,"countryCode":80,"cosmosGeoPoint":94,"geoPoint":98,"contacts":99},"Herlev",{"type":82,"coordinates":95},[96,97],12.43998,55.72366,{"lat":97,"lon":96},[100,101,102],{"name":66,"role":67,"phone":68,"phoneExt":16,"email":69},{"name":71,"role":67,"phone":72,"phoneExt":16,"email":73},{"name":103,"role":104,"phone":16,"phoneExt":16,"email":16},"Morten Schou","PRINCIPAL_INVESTIGATOR",{"facility":106,"status":77,"city":93,"state":16,"zip":16,"country":79,"countryCode":80,"cosmosGeoPoint":107,"geoPoint":109,"contacts":16},"Steno Diabetes Center Copenhagen",{"type":82,"coordinates":108},[96,97],{"lat":97,"lon":96},{"facility":111,"status":77,"city":112,"state":16,"zip":16,"country":79,"countryCode":80,"cosmosGeoPoint":113,"geoPoint":117,"contacts":16},"Nordsjællands Hospital","Hillerød",{"type":82,"coordinates":114},[115,116],12.30081,55.92791,{"lat":116,"lon":115},{"facility":119,"status":77,"city":120,"state":16,"zip":16,"country":79,"countryCode":80,"cosmosGeoPoint":121,"geoPoint":125,"contacts":16},"Holbæk Sygehus","Holbæk",{"type":82,"coordinates":122},[123,124],11.71279,55.7175,{"lat":124,"lon":123},{"facility":127,"status":77,"city":128,"state":16,"zip":16,"country":79,"countryCode":80,"cosmosGeoPoint":129,"geoPoint":133,"contacts":16},"Hvidovre Hospital","Hvidovre",{"type":82,"coordinates":130},[131,132],12.47708,55.64297,{"lat":132,"lon":131},{"facility":135,"status":77,"city":136,"state":16,"zip":16,"country":79,"countryCode":80,"cosmosGeoPoint":137,"geoPoint":141,"contacts":16},"Sjællands Universitetshospital","Køge",{"type":82,"coordinates":138},[139,140],12.18214,55.45802,{"lat":140,"lon":139},{"facility":143,"status":77,"city":144,"state":16,"zip":16,"country":79,"countryCode":80,"cosmosGeoPoint":145,"geoPoint":149,"contacts":16},"Nykøbing F. Sygehus","Nykøbing Falster",{"type":82,"coordinates":146},[147,148],11.87425,54.76906,{"lat":148,"lon":147},{"facility":135,"status":77,"city":151,"state":16,"zip":16,"country":79,"countryCode":80,"cosmosGeoPoint":152,"geoPoint":156,"contacts":16},"Roskilde",{"type":82,"coordinates":153},[154,155],12.08035,55.64152,{"lat":155,"lon":154},{"facility":158,"status":77,"city":159,"state":16,"zip":16,"country":79,"countryCode":80,"cosmosGeoPoint":160,"geoPoint":164,"contacts":16},"Bornholms Hospital","Rønne",{"type":82,"coordinates":161},[162,163],14.70664,55.10091,{"lat":163,"lon":162},{"facility":166,"status":77,"city":167,"state":16,"zip":16,"country":79,"countryCode":80,"cosmosGeoPoint":168,"geoPoint":172,"contacts":16},"Slagelse Sygehus","Slagelse",{"type":82,"coordinates":169},[170,171],11.35459,55.40276,{"lat":171,"lon":170},{"type":104,"investigatorFullName":174,"investigatorTitle":175,"investigatorAffiliation":5,"oldNameTitle":16,"oldOrganization":16},"Daniel Mølager Christensen","Investigator","100565445",false,"NCT06642272","A Pragmatic Trial Comparing Empagliflozin and Dapagliflozin Through Cluster Randomization Embedded in the Electronic Health Record","APPLE TREE","Inclusion Criteria:\n\n* Adults aged 18 years or more\n\nExclusion Criteria:\n\n* Incapabability of giving informed consent\n* Withdrawal of informed consent","ALL","18 Years",{"count":185,"type":186},17200,"ESTIMATED","INTERVENTIONAL",[189],"PHASE4","The aim of this clinical trial is investigate the comparative effectiveness of empagliflozin and dapagliflozin for the treatment of diabetes, chronic kidney disease, and heart failure.\n\nPatients who are prescribed either empagliflozin or dapagliflozin, as part of daily clinical practice at the participating sites, will be included in the study. Treatment will be randomized automatically through the electronic health record software in clusters defined by time of day.\n\nhttps:\u002F\u002Fwww.appletreestudy.com",[192,193,194],"Diabetes Mellitus, Type 2","Heart Failure","Chronic Kidney Diseases","2024-11-01",{"date":197,"type":198},"2024-11-05","ACTUAL",{"date":200,"type":198},"2024-10-10",{"date":202,"type":186},"2028-12-31",{"name":5,"class":6},12]