[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560863":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":34,"centralContacts":39,"locations":49,"responsibleParty":70,"collaborators":11,"id":73,"slug":11,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":11,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":11,"enrollmentInfo":81,"targetDuration":11,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":11,"overallStatus":52,"whyStopped":11,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8,14,17,20,23,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo, then Propranolol, then Metoprolol","EXPERIMENTAL",null,[13],"Other: Ambient Heat",{"label":15,"type":10,"description":11,"interventionNames":16},"Placebo, then Metoprolol, then Propranolol",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"Propranolol, then Placebo, then Metoprolol",[13],{"label":21,"type":10,"description":11,"interventionNames":22},"Propranolol, then Metoprolol, then Placebo",[13],{"label":24,"type":10,"description":11,"interventionNames":25},"Metoprolol, then Placebo, then Propranolol",[13],{"label":27,"type":10,"description":11,"interventionNames":28},"Metoprolol, then Propranolol, then Placebo",[13],[30],{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":11},"Ambient Heat","Subjects will spend 3-hours in a heat chamber at 41°C and 40% humidity.",[24,27,15,9,21,18],[35],{"name":36,"affiliation":37,"role":38},"Craig Crandall, PhD","Univ of Texas Southwestern Med Ctr","PRINCIPAL_INVESTIGATOR",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":11,"email":44},"Erin Harper, MS","CONTACT","214-345-4737","erinharper@texashealth.org",{"name":46,"role":42,"phone":47,"phoneExt":11,"email":48},"Courtney Kirby, RN","214-345-6502","courtneykirby@texashealth.org",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"IEEM Texas Health Presbyterian Hospital Dallas","RECRUITING","Dallas","Texas","75231","United States",{"type":58,"coordinates":59},"Point",[60,61],-96.80667,32.78306,{"lat":61,"lon":60},[64,68,69],{"name":65,"role":42,"phone":66,"phoneExt":11,"email":67},"Taysom Wallace, MS","214-345-5022","taysomwallace@texashealth.org",{"name":46,"role":42,"phone":47,"phoneExt":11,"email":48},{"name":36,"role":38,"phone":11,"phoneExt":11,"email":11},{"type":38,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Craig Crandall","Professor of Internal Medicine","100560863",false,"NCT06582680","Aging, Beta Blockers, and Thermoregulatory Responses","Inclusion Criteria:\n\n* Healthy and free of any significant medical problems\n* Normal resting electrocardiogram\n* 65+ years of age\n* Controlled cholesterol of less than 200 mg\u002Fdl\n* Controlled blood pressure of less than 140\u002F90 mmHg\n\nExclusion Criteria:\n\n* Known diseases or other chronic conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia\n* Serious abnormalities detected on routine screening\n* Taking prescribed medications or over-the-counter medications that have known influences on either cardiac function or sweating\n* Current smokers, as well as individuals who regularly smoked within the past 3 years\n* body mass index ≥31 kg\u002Fm2",true,"ALL","65 Years",{"count":82,"type":83},22,"ESTIMATED","INTERVENTIONAL",[86],"PHASE4","This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.",[89,90],"Heat Stress","Aging","2025-10-21",{"date":93,"type":94},"2025-10-23","ACTUAL",{"date":96,"type":94},"2024-10-04",{"date":98,"type":83},"2026-09-30",{"name":5,"class":6},1]