[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634166":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":32,"locations":33,"responsibleParty":53,"collaborators":57,"id":60,"slug":32,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":32,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":36,"whyStopped":32,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Kasr El Aini Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Antihistamine","ACTIVE_COMPARATOR","chlorpheniramine 0.25 mg\u002FKg in 2 ml",[13],"Drug: Antihestamine",{"label":15,"type":16,"description":17,"interventionNames":18},"control","PLACEBO_COMPARATOR","equal volume of normal saline",[19],"Drug: Placebo",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Antihestamine","chlorpheniramine 0.25 mg\u002FKg in 2 ml immediately after separation from CPB, before protamine administration",[9],[27],"chlorpheniramine",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Placebo","equal volume normal saline",[15],null,[34],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Misr Universty for Scince and Technology","RECRUITING","Giza","October","12582","Egypt",{"type":42,"coordinates":43},"Point",[44,45],31.20861,30.00944,{"lat":45,"lon":44},[48],{"name":49,"role":50,"phone":51,"phoneExt":32,"email":52},"Ahmed Mohamed Elhaddad, Assisstant Professor","CONTACT","0201224042847","drblacksmith5@kasralainy.edu.eg",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Ahmed Mohamed Mohamed Elhaddad","assisstant professor",[58],{"name":59,"class":6},"Misr University for Science and Technology","100634166",false,"NCT07536152","Antihistamine for Prevention of HTR After Blood Primed CPB","Prophylactic Antihistamine for Prevention of Hypotensive Transfusion Reaction After Blood Primed Cardiopulmonary Bypass in Pediatric Cardiac Surgery: a Randomized-controlled Study","HTR - CPB","Inclusion Criteria:\n\n* Acyanotic congenital heart disease.\n* Age :1 -7 years.\n* Genre: both.\n\nExclusion Criteria:\n\n* Redo patient.\n* History of allergy to antihistamines.\n* Bleeding disorders with INR \\> 1.5 and\u002For platelets \\\u003C 50,000.\n* Emergency procedure.","ALL","1 Year","7 Years",{"count":71,"type":72},40,"ESTIMATED","INTERVENTIONAL",[75],"PHASE4","This study will be a randomized, double-blinded, placebo-controlled study conducted at a university hospital. Forty children undergoing elective repair of a congenital heart defect will be included. The patients will be randomly allocated (20 patients per group) to receive a single intravenous dose of combined chlorpheniramine or normal saline immediately after separation from CPB, before protamine administration.",[78],"Blood Transfusion Associated Adverse Reactions",[80],"prevention of hypotensive transfusion reaction","2026-04-16",{"date":83,"type":84},"2026-04-21","ACTUAL",{"date":86,"type":84},"2026-03-01",{"date":88,"type":72},"2026-12",{"name":5,"class":6},1]