[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626361":3},{"organization":4,"outcomesModule":7,"designInfo":30,"detailedDescription":38,"studyPopulation":29,"armGroups":39,"interventions":50,"overallOfficials":58,"centralContacts":62,"locations":67,"responsibleParty":84,"collaborators":29,"id":86,"slug":29,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":87,"sex":92,"minAge":93,"maxAge":29,"enrollmentInfo":94,"targetDuration":29,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":69,"whyStopped":29,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"University of California, San Francisco","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":29},[9],{"measure":10,"description":11,"timeFrame":12},"Pain score on the Visual Analog Scale (VAS)","Whether atropine use impacts post-operative pain score on the standard Visual Analog Scale (VAS)","1 month",[14,17,20,23,26],{"measure":15,"description":16,"timeFrame":12},"Anterior chamber inflammation (aqueous cell and flare)","Whether atropine impacts the occurrence of post-operative inflammation, quantified as aqueous cell and flare, using the Standardization of Uveitis Nomenclature (SUN) Criteria",{"measure":18,"description":19,"timeFrame":12},"Cystoid macular edema detected by optical coherence tomography","Whether atropine impacts the occurrence of cystoid macular edema after surgery, detected by optical coherence tomography scanning of the retina",{"measure":21,"description":22,"timeFrame":12},"Time to visual recovery","Whether atropine impacts the time to visual recovery",{"measure":24,"description":25,"timeFrame":12},"Intraocular pressure","Whether atropine impacts intraocular pressure after surgery",{"measure":27,"description":28,"timeFrame":12},"Posterior synechiae formation","Presence or absence of posterior synechiae assessed by slit lamp examination at post-operative visits",null,{"allocation":31,"interventionModel":32,"interventionModelDescription":29,"primaryPurpose":33,"observationalModel":29,"timePerspective":29,"maskingInfo":34},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":35,"maskingDescription":29,"whoMasked":36},"SINGLE",[37],"INVESTIGATOR","Atropine eyedrops are often used after certain eye surgeries. This study will compare several outcomes following surgery in patients either using or not using this treatment.",[40,44],{"label":41,"type":42,"description":43,"interventionNames":29},"Control","NO_INTERVENTION","No atropine",{"label":45,"type":46,"description":47,"interventionNames":48},"Experimental","EXPERIMENTAL","Participant uses atropine eyedrops",[49],"Drug: Atropine 1%",[51],{"type":52,"name":53,"description":54,"armGroupLabels":55,"otherNames":56},"DRUG","Atropine 1%","Subtraction of atropine eyedrops from post-operative treatment regimen",[45],[57],"Atropine",[59],{"name":60,"affiliation":5,"role":61},"Jay Stewart, MD","PRINCIPAL_INVESTIGATOR",[63],{"name":60,"role":64,"phone":65,"phoneExt":29,"email":66},"CONTACT","415-353-9635","eyestudy@ucsf.edu",[68],{"facility":5,"status":69,"city":70,"state":71,"zip":72,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":80,"contacts":81},"RECRUITING","San Francisco","California","94143","United States","US",{"type":76,"coordinates":77},"Point",[78,79],-122.41942,37.77493,{"lat":79,"lon":78},[82],{"name":83,"role":64,"phone":65,"phoneExt":29,"email":66},"Jay Stewart",{"type":85,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100626361",false,"NCT07434635","APPRAISE: Assessment of Pain and Posterior Synechiae Reduction With Atropine, an Investigation of Post-Surgical Eyes","APPRAISE","Inclusion Criteria:\n\n* patient undergoing vitrectomy surgery\n* able to give informed consent\n\nExclusion Criteria:\n\n* post-operative eyedrop regimens that include topical non steroidal anti-inflammatory medications\n* subjects with altered post-operative eyedrop schedule for enhanced inflammation control\n* documented allergy to atropine","ALL","18 Years",{"count":95,"type":96},62,"ESTIMATED","INTERVENTIONAL",[99],"PHASE4","The study will evaluate whether atropine eyedrops are beneficial when used after certain eye surgeries.",[102],"Eye Disorders",[104,105],"atropine","eye surgery","2026-02-19",{"date":108,"type":109},"2026-02-25","ACTUAL",{"date":111,"type":96},"2026-02",{"date":113,"type":96},"2029-02",{"name":5,"class":6},1]