Beta-lactam Plus Levofloxacin to Enhance Therapy in Streptococcal Septicemia
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorMahidol University
About this trial
A double-blind randomized controlled trial comparing beta-lactam plus levofloxacin versus beta-lactam monotherapy for the treatment of Streptococcal bacteremia
Eligibility criteria
Qualifiers
Adults age>18 years
Blood culture positive for Streptococcus (<72 hours before enrollment)
at least 1 bottle of S. pyogenes, S. agalactiae, S. pneumoniae, S. suis
at least 2 bottle of other Streptococci
Disqualifiers
Known allergy to beta-lactam or fluroquinolone antibiotics
Pregnancy or lactating mother
EKG with QT prolongation
Diagnosis of infective endocarditis
Trial design
Treatments tested in this trial
- Beta-lactam monotherapy
- Beta-lactam plus levofloxacin combination therapy
Treatment groups
165 Participants
are divided into 2 treatment groupsLocations
4Faculty of Medicine Siriraj Hospital Bangkok Thailand
Maharaj Nakorn Chiang Mai Hospital Chiang Mai Thailand
Maharaj Nakhon Ratchasima Nakhon Ratchasima Thailand
Ratchburi Hospital Ratchaburi Thailand
Sponsors and collaborators
Mahidol University
Lead sponsor
Source ClinicalTrials.gov