[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584658":3},{"organization":4,"outcomesModule":7,"designInfo":47,"detailedDescription":11,"studyPopulation":11,"armGroups":56,"interventions":68,"overallOfficials":78,"centralContacts":83,"locations":93,"responsibleParty":226,"collaborators":11,"id":228,"slug":11,"hasResults":229,"nctId":230,"briefTitle":231,"officialTitle":231,"acronym":11,"eligibilityCriteria":232,"healthyVolunteers":229,"sex":233,"minAge":234,"maxAge":11,"enrollmentInfo":235,"targetDuration":11,"studyType":238,"phases":239,"briefSummary":241,"conditions":242,"keywords":11,"overallStatus":96,"whyStopped":11,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":253},{"fullName":5,"class":6},"Copenhagen Respiratory Research","NETWORK",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":37},[9],{"measure":10,"description":11,"timeFrame":12},"Readmission for COPD exacerbation or death from all causes",null,"30 days",[14,17,20,22,25,27,29,32,34],{"measure":15,"description":11,"timeFrame":16},"Days alive and out of hospital","14 days",{"measure":18,"description":11,"timeFrame":19},"Mortality","90 days",{"measure":21,"description":11,"timeFrame":19},"Readmission for COPD exacerbation",{"measure":23,"description":24,"timeFrame":19},"All-cause infections","Defined as a new prescription of antibacterial medication.",{"measure":26,"description":11,"timeFrame":12},"Need for mechanical ventilation",{"measure":28,"description":11,"timeFrame":12},"New onset infections",{"measure":30,"description":11,"timeFrame":31},"Daily amount of insulin administered to the patient by day 7 or discharge from hospital","7 days",{"measure":33,"description":11,"timeFrame":12},"Gastrointestinal bleeding",{"measure":35,"description":36,"timeFrame":31},"Blood glucose levels","Measured at day 3 and day 7",[38,41,44],{"measure":39,"description":40,"timeFrame":31},"Procalcitonin (PCT) at baseline","Procalcitonin (PCT) at baseline, day 3 and day 7. If still at hospital.",{"measure":42,"description":43,"timeFrame":31},"C-reactive protein (CRP) at baseline","C-reactive protein (CRP) at baseline, day 3 and day 7. If still in hospital.",{"measure":45,"description":46,"timeFrame":31},"Blood eosinophil count (EOS) at baseline","Blood eosinophil count (EOS) at baseline, day 3 and day 7. If still in hospital.",{"allocation":48,"interventionModel":49,"interventionModelDescription":50,"primaryPurpose":51,"observationalModel":11,"timePerspective":11,"maskingInfo":52},"RANDOMIZED","PARALLEL","The study is a cluster randomized controlled trial. It consists of two arms, in which patients will be randomized to receive treatment with either Hydrocortisone or Methylprednisolone.","TREATMENT",{"masking":53,"maskingDescription":11,"whoMasked":54},"SINGLE",[55],"OUTCOMES_ASSESSOR",[57,63],{"label":58,"type":59,"description":60,"interventionNames":61},"Treatment with Hydrocortisone.","ACTIVE_COMPARATOR","This arm will recieve a dose of 200 mg of Hydrocortisone intravenously once daily for five days.",[62],"Drug: Hydrocortisone",{"label":64,"type":59,"description":65,"interventionNames":66},"Treatment with Methylprednisolone","This arm will recieve a dose of 40 mg of Methylprednisolone intravenously once daily for five days.",[67],"Drug: Methylprednisolone (drug)",[69,74],{"type":70,"name":71,"description":72,"armGroupLabels":73,"otherNames":11},"DRUG","Methylprednisolone (drug)","ATC code: H02AB06. Can be changed to Prednisolone 50 mg orally.",[64],{"type":70,"name":75,"description":76,"armGroupLabels":77,"otherNames":11},"Hydrocortisone","ATC-code: H02AB09. Can be changed to 50 mg x 4 daily orally if appropriate.",[58],[79],{"name":80,"affiliation":81,"role":82},"Jens-Ulrik Stæhr Jensen, MD, PHD","COP:RESP","STUDY_DIRECTOR",[84,89],{"name":80,"role":85,"phone":86,"phoneExt":87,"email":88},"CONTACT","38673057","+45","jens.ulrik.jensen@regionh.dk",{"name":90,"role":85,"phone":91,"phoneExt":87,"email":92},"Pradeesh Sivapalan, MD, PHD","29880601","pradeesh.sivapalan.02@regionh.dk",[94,108,118,124,133,142,152,161,171,181,190,199,208,217],{"facility":95,"status":96,"city":97,"state":98,"zip":99,"country":100,"countryCode":101,"cosmosGeoPoint":102,"geoPoint":107,"contacts":11},"Bornholm Hospital","RECRUITING","Rønne","Bornholm","3700","Denmark","DK",{"type":103,"coordinates":104},"Point",[105,106],14.70664,55.10091,{"lat":106,"lon":105},{"facility":109,"status":96,"city":110,"state":111,"zip":112,"country":100,"countryCode":101,"cosmosGeoPoint":113,"geoPoint":117,"contacts":11},"Amager Hospital","Copenhagen","Copenhagen City","2300",{"type":103,"coordinates":114},[115,116],12.56553,55.67594,{"lat":116,"lon":115},{"facility":119,"status":96,"city":110,"state":111,"zip":120,"country":100,"countryCode":101,"cosmosGeoPoint":121,"geoPoint":123,"contacts":11},"Bispebjerg Hospital","2400",{"type":103,"coordinates":122},[115,116],{"lat":116,"lon":115},{"facility":125,"status":96,"city":126,"state":111,"zip":127,"country":100,"countryCode":101,"cosmosGeoPoint":128,"geoPoint":132,"contacts":11},"Frederiksberg Hospital","Frederiksberg","2000",{"type":103,"coordinates":129},[130,131],12.53463,55.67938,{"lat":131,"lon":130},{"facility":134,"status":96,"city":135,"state":111,"zip":136,"country":100,"countryCode":101,"cosmosGeoPoint":137,"geoPoint":141,"contacts":11},"Gentofte Hospital","Hellerup","2900",{"type":103,"coordinates":138},[139,140],12.57093,55.73204,{"lat":140,"lon":139},{"facility":143,"status":96,"city":144,"state":145,"zip":146,"country":100,"countryCode":101,"cosmosGeoPoint":147,"geoPoint":151,"contacts":11},"Herlev Hospital","Herlev","Copnhagen Surroundings","2730",{"type":103,"coordinates":148},[149,150],12.43998,55.72366,{"lat":150,"lon":149},{"facility":153,"status":96,"city":154,"state":145,"zip":155,"country":100,"countryCode":101,"cosmosGeoPoint":156,"geoPoint":160,"contacts":11},"Hvidovre Hospital","Hvidovre","2650",{"type":103,"coordinates":157},[158,159],12.47708,55.64297,{"lat":159,"lon":158},{"facility":162,"status":96,"city":163,"state":164,"zip":165,"country":100,"countryCode":101,"cosmosGeoPoint":166,"geoPoint":170,"contacts":11},"Nordsjællands Hospital","Hillerød","North Zealand","3400",{"type":103,"coordinates":167},[168,169],12.30081,55.92791,{"lat":169,"lon":168},{"facility":172,"status":96,"city":173,"state":174,"zip":175,"country":100,"countryCode":101,"cosmosGeoPoint":176,"geoPoint":180,"contacts":11},"Holbæk Sygehus","Holbæk","Region Sjælland","4300",{"type":103,"coordinates":177},[178,179],11.71279,55.7175,{"lat":179,"lon":178},{"facility":182,"status":96,"city":183,"state":174,"zip":184,"country":100,"countryCode":101,"cosmosGeoPoint":185,"geoPoint":189,"contacts":11},"University Hospital of Region Zealand, Køge","Køge","4600",{"type":103,"coordinates":186},[187,188],12.18214,55.45802,{"lat":188,"lon":187},{"facility":191,"status":96,"city":192,"state":174,"zip":193,"country":100,"countryCode":101,"cosmosGeoPoint":194,"geoPoint":198,"contacts":11},"Næstved Sygehus","Næstved","4700",{"type":103,"coordinates":195},[196,197],11.76092,55.22992,{"lat":197,"lon":196},{"facility":200,"status":96,"city":201,"state":174,"zip":202,"country":100,"countryCode":101,"cosmosGeoPoint":203,"geoPoint":207,"contacts":11},"Ringsted Sygehus","Ringsted","4100",{"type":103,"coordinates":204},[205,206],11.79011,55.4426,{"lat":206,"lon":205},{"facility":209,"status":96,"city":210,"state":174,"zip":211,"country":100,"countryCode":101,"cosmosGeoPoint":212,"geoPoint":216,"contacts":11},"University Hospital of Region Zealand, Roskilde","Roskilde","4000",{"type":103,"coordinates":213},[214,215],12.08035,55.64152,{"lat":215,"lon":214},{"facility":218,"status":96,"city":219,"state":174,"zip":220,"country":100,"countryCode":101,"cosmosGeoPoint":221,"geoPoint":225,"contacts":11},"Slagelse Sygehus","Slagelse","4200",{"type":103,"coordinates":222},[223,224],11.35459,55.40276,{"lat":224,"lon":223},{"type":227,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100584658",false,"NCT06892210","Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)","Inclusion Criteria:\n\n* Age ≥40 years\n* Chronic obstructive pulmonary disease with acute exacerbation, unspecified: ICDJ44\n\nExclusion Criteria:\n\n* All diagnoses that would merit treatment with a specific corticosteroid\n* Pregnant or breastfeeding women\n* Active tuberculosis or invasive fungal infection","ALL","40 Years",{"count":236,"type":237},2000,"ESTIMATED","INTERVENTIONAL",[240],"PHASE4","The goal of this cluster randomized controlled trial is to determine the optimal treatment for Acute Exacerbation of Chronic Obstructive Pulmonary Disease. The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 40 years old diagnosed with chronic obstructive pulmonary disease with acute exacerbation. The main question is whether there is a difference in readmission for COPD excerbation or all cause mortality within thirty days.\n\nParticipants will randomized to receive treatment with either hydrocortisone or prednisolone.",[243],"Chronic Obstructive Pulmonary Disease (COPD)","2026-03-16",{"date":246,"type":247},"2026-03-18","ACTUAL",{"date":249,"type":247},"2026-03-10",{"date":251,"type":237},"2030-11-01",{"name":5,"class":6},14]