[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611393":3},{"organization":4,"outcomesModule":7,"designInfo":17,"detailedDescription":11,"studyPopulation":11,"armGroups":25,"interventions":36,"overallOfficials":45,"centralContacts":50,"locations":11,"responsibleParty":59,"collaborators":11,"id":62,"slug":11,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":11,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":11,"enrollmentInfo":70,"targetDuration":11,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":85,"whyStopped":11,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":11},{"fullName":5,"class":6},"Nova Scotia Health Authority","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":11,"otherOutcomes":11},[9,13],{"measure":10,"description":11,"timeFrame":12},"Time to complete recovery of motor block",null,"Time from the intrathecal drug injection to the first documented instance of complete motor block recovery Bromage 0. Within approximately 2 hours for the Chloroprocaine group and 4 hours for the Mepivacaine group.",{"measure":14,"description":15,"timeFrame":16},"Time to complete motor block recovery of lower limbs after spinal anesthesia","Motor block will be assessed by PACU nurses in PACU using standard Bromage motor scale.","From the time of intrathecal drug injection to PACU discharge. Within approximately 3 hours for the Chloroprocaine group and 5 hours for the Mepivacaine group.",{"allocation":18,"interventionModel":19,"interventionModelDescription":11,"primaryPurpose":6,"observationalModel":11,"timePerspective":11,"maskingInfo":20},"RANDOMIZED","PARALLEL",{"masking":21,"maskingDescription":22,"whoMasked":23},"SINGLE","Surgeons, PACU Nurses, OR Nurses, Physical therapists",[24],"CARE_PROVIDER",[26,32],{"label":27,"type":28,"description":29,"interventionNames":30},"One arm receives spinal Mepivacaine 50 mg","ACTIVE_COMPARATOR","One arm receives spinal Mepivacaine 50mg for total knee arthroplasty with adductor canal block",[31],"Drug: Mepivacaine Injection",{"label":33,"type":28,"description":11,"interventionNames":34},"Spinal Chloroprocaine group",[35],"Drug: Chloroprocaine Injection",[37,42],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":11},"DRUG","Mepivacaine Injection","Comparing time to motor block recovery in PACU, time to PACU discharge, time to ambulation and length of hospital stay",[27],{"type":38,"name":43,"description":40,"armGroupLabels":44,"otherNames":11},"Chloroprocaine Injection",[33],[46],{"name":47,"affiliation":48,"role":49},"HUSAM M NASHNOUSH, MBBCH, FRCPC","Dalhousie University","PRINCIPAL_INVESTIGATOR",[51,55],{"name":47,"role":52,"phone":53,"phoneExt":11,"email":54},"CONTACT","001-902-410-9062","husam.nashnoush@nshealth.ca",{"name":56,"role":52,"phone":57,"phoneExt":11,"email":58},"Mohamed H Nashnoush, MED2","001-902-266-6010","mnashnoush@dal.ca",{"type":49,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Husam Nashnoush","Doctor Husam Nashnoush, MBBCH, FRCPC, Anesthesia Department, Central Zone, DGH, Halifax , NS","100611393",false,"NCT07239999","Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty","Randomized Controlled Trial Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty","Inclusion Criteria:\n\n* ASA I-III\n* Elective outpatient TKA\n* BMI less than 40\n* Ability to provide surgical consent\n\nExclusion Criteria:\n\n* Patient refusal\n* Opioid tolerant\n* Any contraindications to spinal anesthesia\n* Chronic opioid use 3months or more","ALL","18 Years",{"count":71,"type":72},170,"ESTIMATED","INTERVENTIONAL",[75],"PHASE4","This study or clinical trial looking to compare 2 types of freezing medications injected into the spinal fluid at the lower back between the vertebrae in patients going to have total knee replacement surgery to check for early legs movement, early discharge from recovery room, walking and hospital discharge. This could save hospital cost of such procedures.",[78,79],"Recovery Period","Anesthesia",[81,82,83,84],"Spinal anesthesia","Outpatient total knee arthroplasty","Mepivacaine","Chloroprocaine","NOT_YET_RECRUITING","2026-02-04",{"date":88,"type":89},"2026-02-06","ACTUAL",{"date":91,"type":72},"2026-03-31",{"date":93,"type":72},"2027-06-15",{"name":5,"class":6}]