[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639649":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":20,"locations":26,"responsibleParty":44,"collaborators":11,"id":48,"slug":11,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":11,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":11,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":73,"whyStopped":11,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Zhongshan Ophthalmic Center, Sun Yat-sen University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Alfentanil Sequential Dose Group","EXPERIMENTAL",null,[13],"Drug: Alfentanil",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"DRUG","Alfentanil","All patients receive 2.5 mg\u002Fkg propofol injected over 30 seconds. Alfentanil is administered 1 minute prior to propofol. The dose is adjusted by steps of 2 µg\u002Fkg based on the previous patient's response (successful insertion = decrease dose; failed insertion = increase dose).",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":11,"email":25},"Rui Zhang, M.D.","CONTACT","+86 15802025520","zhangr52@mail.sysu.edu.cn",[27],{"facility":28,"status":11,"city":29,"state":30,"zip":31,"country":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Department of Anesthesiology, Zhongshan Ophthalmic Center, Sun Yat-sen University","Guangzhou","Guangdong","510000","China",{"type":34,"coordinates":35},"Point",[36,37],113.25,23.11667,{"lat":37,"lon":36},[40],{"name":41,"role":23,"phone":42,"phoneExt":11,"email":43},"Tairan Lin, M.D.","+86 15622130745","talonlam@foxmail.com",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Rui Zhang","Associate Chief Physician","100639649",false,"NCT07581665","Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children","Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children: A Prospective, Up-and-Down Sequential Allocation Study","Inclusion Criteria:\n\n* Aged 7 to 12 years\n* Undergoing elective day surgery\n* ASA physical status I-II\n* Body Mass Index (BMI) between 14 and 24 kg\u002Fm²\n* Accompanied by a fully capable guardian within 24 hours after discharge\n\nExclusion Criteria:\n\n* Allergy to opioids\n* Unresolved upper respiratory tract infection within the past 1 week\n* Abnormal heart, lung, liver, or kidney function, or metabolic diseases\n* Airway anatomical abnormalities (e.g., micrognathia, laryngomalacia, macroglossia) or OSAHS (Obstructive Sleep Apnea-Hypopnea Syndrome)\n* Use of analgesics, sedatives, or other psychotropic drugs within the past 2 weeks\n* Refusal to sign the informed consent form","ALL","7 Years","12 Years",{"count":58,"type":59},40,"ESTIMATED","INTERVENTIONAL",[62],"PHASE4","This study uses a prospective, up-and-down sequential allocation method to determine the median effective dose (ED50) and 95% effective dose (ED95) of alfentanil combined with propofol for successful laryngeal mask airway (LMA) insertion in children aged 7-12 undergoing elective day surgery.",[65,66,67,68],"Pediatric Anesthesia","Airway Management","General Anesthesia","LMA",[17,70,65,68,71,72],"Propofol","Dixon Method","Effective dose","NOT_YET_RECRUITING","2026-05-05",{"date":76,"type":77},"2026-05-12","ACTUAL",{"date":79,"type":59},"2026-05-01",{"date":81,"type":59},"2027-03-30",{"name":5,"class":6},1]