[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100543687":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":212,"collaborators":26,"id":216,"slug":26,"hasResults":217,"nctId":218,"briefTitle":219,"officialTitle":219,"acronym":26,"eligibilityCriteria":220,"healthyVolunteers":217,"sex":221,"minAge":222,"maxAge":26,"enrollmentInfo":223,"targetDuration":26,"studyType":226,"phases":227,"briefSummary":229,"conditions":230,"keywords":26,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":241},{"fullName":5,"class":6},"China Medical University, China","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control: 80% Oxygen","PLACEBO_COMPARATOR","Before anesthesia induction, the participants inhaled 100% oxygen through the mask for 3 minutes. After successful anesthesia induction, the fraction of inspired oxygen (FiO2) will be adjusted to 80%, and the total gas flow rate will be set at 2L\u002Fminute. All patients will receive treatment through the lung-protective ventilation strategy. The respiratory parameters are VT: 6-8mL\u002Fkg, positive end-expiratory pressure (PEEP), 6-8 cmH2O; RR: 1:2, and respiratory rate will be adjusted by maintaining a partial pressure of carbon dioxide at 35-45 mmHg. Manual lung recruitment maneuvers will be performed after tracheal intubation and before tracheal extubation. Blood will be collected for blood gas analysis within 48 hours after surgery.",[13],"Drug: 80% Oxygen",{"label":15,"type":16,"description":17,"interventionNames":18},"Experimental: 40% Oxygen","EXPERIMENTAL","Before anesthesia induction, the participants inhaled 100% oxygen through the mask for 3 minutes. After successful anesthesia induction, FiO2 will be adjusted to 40%, and the total gas flow rate will be set at 2L\u002Fminute. All patients will receive treatment through the lung-protective ventilation strategy. The respiratory parameters are VT: 6-8mL\u002Fkg, positive end-expiratory pressure (PEEP), 6-8 cmH2O; RR: 1:2, and respiratory rate will be adjusted by maintaining a partial pressure of carbon dioxide at 35-45 mmHg. Manual lung recruitment maneuvers will be performed after tracheal intubation and before tracheal extubation. However, when intraoperative oxygen saturation is less than 94%, the manual lung recruitment maneuver will also be performed. Patients should transfer to 80% Oxygen group if intraoperative oxygen saturation less than 85%.Blood will be collected for blood gas analysis within 48 hours after surgery.",[19],"Drug: 40% Oxygen",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","80% Oxygen","After successful anesthesia induction, the fraction of inspired oxygen (FiO2) will be adjusted to 80%, and the total gas flow rate will be set at 2L\u002Fminute.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"40% Oxygen","After successful anesthesia induction, the fraction of inspired oxygen (FiO2) will be adjusted to 40%, and the total gas flow rate will be set at 2L\u002Fminute.",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Tianhao Zhang, M.D.","CONTACT","+862483283100","zhth774176947@163.com",{"name":38,"role":34,"phone":35,"phoneExt":26,"email":39},"Yang An, M.D.","cmu_ay2016@163.com",[41,59,70,81,92,103,111,122,130,141,152,163,171,182,193,201],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"the First Hospital of China Medical University","RECRUITING","Shenyang","Liaoning","110001","China",{"type":49,"coordinates":50},"Point",[51,52],123.43278,41.79222,{"lat":52,"lon":51},[55],{"name":56,"role":34,"phone":57,"phoneExt":26,"email":58},"Wenfei Tan, M.D.,Ph.D","024-83283100","winfieldtan@hotmail.com",{"facility":60,"status":43,"city":61,"state":26,"zip":26,"country":47,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Beijing Friendship Hospital, Capital Medical University","Beijing",{"type":49,"coordinates":63},[64,65],116.39723,39.9075,{"lat":65,"lon":64},[68],{"name":69,"role":34,"phone":26,"phoneExt":26,"email":26},"Yun Wang",{"facility":71,"status":43,"city":72,"state":26,"zip":26,"country":47,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Sichuan Provincial People's Hospital","Chendu",{"type":49,"coordinates":74},[75,76],121.03163,30.92504,{"lat":76,"lon":75},[79],{"name":80,"role":34,"phone":26,"phoneExt":26,"email":26},"Qian Lei",{"facility":82,"status":43,"city":83,"state":26,"zip":26,"country":47,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Chifeng Municipal Hospital","Chifeng",{"type":49,"coordinates":85},[86,87],118.96361,42.26833,{"lat":87,"lon":86},[90],{"name":91,"role":34,"phone":26,"phoneExt":26,"email":26},"Jiannan Song",{"facility":93,"status":43,"city":94,"state":26,"zip":26,"country":47,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"Dalian Third People's Hospital","Dalian",{"type":49,"coordinates":96},[97,98],121.60222,38.91222,{"lat":98,"lon":97},[101],{"name":102,"role":34,"phone":26,"phoneExt":26,"email":26},"Shiling Zhao",{"facility":104,"status":43,"city":94,"state":26,"zip":26,"country":47,"cosmosGeoPoint":105,"geoPoint":107,"contacts":108},"First Affiliated Hospital, Dalian Medical University",{"type":49,"coordinates":106},[97,98],{"lat":98,"lon":97},[109],{"name":110,"role":34,"phone":26,"phoneExt":26,"email":26},"Yong Luan",{"facility":112,"status":43,"city":113,"state":26,"zip":26,"country":47,"cosmosGeoPoint":114,"geoPoint":118,"contacts":119},"First Affiliated Hospital of Harbin Medical University","Harbin",{"type":49,"coordinates":115},[116,117],126.65,45.75,{"lat":117,"lon":116},[120],{"name":121,"role":34,"phone":26,"phoneExt":26,"email":26},"Kun Wang",{"facility":123,"status":43,"city":113,"state":26,"zip":26,"country":47,"cosmosGeoPoint":124,"geoPoint":126,"contacts":127},"Harbin Medical University Cancer Hospital",{"type":49,"coordinates":125},[116,117],{"lat":117,"lon":116},[128],{"name":129,"role":34,"phone":26,"phoneExt":26,"email":26},"Fei Han",{"facility":131,"status":43,"city":132,"state":26,"zip":26,"country":47,"cosmosGeoPoint":133,"geoPoint":137,"contacts":138},"First Medical University and Shandong Provincial Qianfoshan Hospital","Jinan",{"type":49,"coordinates":134},[135,136],116.99722,36.66833,{"lat":136,"lon":135},[139],{"name":140,"role":34,"phone":26,"phoneExt":26,"email":26},"Jianbo Wu",{"facility":142,"status":43,"city":143,"state":26,"zip":26,"country":47,"cosmosGeoPoint":144,"geoPoint":148,"contacts":149},"First Affiliated Hospital of Kunming Medical University","Kunming",{"type":49,"coordinates":145},[146,147],102.71833,25.03889,{"lat":147,"lon":146},[150],{"name":151,"role":34,"phone":26,"phoneExt":26,"email":26},"Jianlin Shao",{"facility":153,"status":43,"city":154,"state":26,"zip":26,"country":47,"cosmosGeoPoint":155,"geoPoint":159,"contacts":160},"Affiliated Hospital of Qingdao University","Qingdao",{"type":49,"coordinates":156},[157,158],120.38042,36.06488,{"lat":158,"lon":157},[161],{"name":162,"role":34,"phone":26,"phoneExt":26,"email":26},"Wei Feng",{"facility":164,"status":43,"city":44,"state":26,"zip":26,"country":47,"cosmosGeoPoint":165,"geoPoint":167,"contacts":168},"Liaoning Cancer Hospital and Institute",{"type":49,"coordinates":166},[51,52],{"lat":52,"lon":51},[169],{"name":170,"role":34,"phone":26,"phoneExt":26,"email":26},"Zeqing Huang",{"facility":172,"status":43,"city":173,"state":26,"zip":26,"country":47,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"Shenzhen People's Hospita","Shenzhen",{"type":49,"coordinates":175},[176,177],114.0683,22.54554,{"lat":177,"lon":176},[180],{"name":181,"role":34,"phone":26,"phoneExt":26,"email":26},"Chaoran Wu",{"facility":183,"status":43,"city":184,"state":26,"zip":26,"country":47,"cosmosGeoPoint":185,"geoPoint":189,"contacts":190},"First Hospital of Hebei Medical University","Shijia Zhuang",{"type":49,"coordinates":186},[187,188],109.84894,34.17775,{"lat":188,"lon":187},[191],{"name":192,"role":34,"phone":26,"phoneExt":26,"email":26},"Li Wang",{"facility":194,"status":43,"city":184,"state":26,"zip":26,"country":47,"cosmosGeoPoint":195,"geoPoint":197,"contacts":198},"Second Hospital of Hebei Medical University",{"type":49,"coordinates":196},[187,188],{"lat":188,"lon":187},[199],{"name":200,"role":34,"phone":26,"phoneExt":26,"email":26},"Lining Huang",{"facility":202,"status":43,"city":203,"state":26,"zip":26,"country":47,"cosmosGeoPoint":204,"geoPoint":208,"contacts":209},"YANBIAN University Hospital（Yanbian Hospital）","Yanbian",{"type":49,"coordinates":205},[206,207],107.6096,36.41442,{"lat":207,"lon":206},[210],{"name":211,"role":34,"phone":26,"phoneExt":26,"email":26},"Yongshan Nan",{"type":213,"investigatorFullName":214,"investigatorTitle":215,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Wenfei Tan","Professor,Chairman","100543687",false,"NCT06359106","Effects of Different Inhaled Oxygen Concentrations on Lung Function in Older Patients After Laparoscopic Gastrointestinal Surgery Under General Anesthesia","Inclusion Criteria:\n\n* Age not less than 65 years\n* American Society of Anesthesiologists grades I-III\n* No history of drug allergies or abnormal anesthesia.\n* The duration of mechanical ventilation was expected to be more than 2 hours.\n* Laparoscopic Gastrointestinal Surgery\n* The preoperative oxygen saturation was not less than 94%.\n* The patients will be planned to extubate in the operating room.\n\nExclusion Criteria:\n\n* History of acute lung injury or acute respiratory distress syndrome (ARDS) within 3 months.\n* Cardiac function Class IV (New York Heart Association classification)\n* Chronic renal failure (renal cell filtration rate \\\u003C30 ml min-11.73\u002Fm2), severe liver disease\n* Patients with blurred consciousness and cognitive dysfunction\n* Severe coagulation dysfunction.\n* Without preoperative oxygen inhalation, blood oxygen level \\\u003C94%, and severe pulmonary dysfunction\n* Patients with endotracheal tubes were admitted to the intensive care unit (ICU) after surgery.\n* Body mass index (BMI) \\>30kg\u002Fm2\n* Inability to complete the study","ALL","65 Years",{"count":224,"type":225},1176,"ESTIMATED","INTERVENTIONAL",[228],"PHASE4","This was a multicenter, prospective, parallel-grouping, randomized controlled clinical study comparing low FiO2 (40%) and high FiO2 (80%) levels in older patients undergoing laparoscopic gastrointestinal surgery.",[231],"Oxygenation Index","2026-01-23",{"date":234,"type":235},"2026-01-26","ACTUAL",{"date":237,"type":235},"2024-07-02",{"date":239,"type":225},"2026-06-30",{"name":5,"class":6},16]