Effects of Minimal-Flow Sevoflurane and Multimodal Analgesia in Head and Neck Cancer Surgery
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18-99
SponsorNational Taiwan University Hospital
About this trial
This study evaluates the anesthetic-sparing and renal protection effects of minimal-flow sevoflurane anesthesia combined with multimodal analgesia using dexmedetomidine, ketamine, and lidocaine in head and neck cancer patients undergoing free flap microvascular surgery. The 2x2 factorial randomized controlled trial aims to compare sevoflurane usage and renal function changes with different fresh gas flow rates and multimodal analgesia.
Eligibility criteria
Qualifiers
Age 18-99 years
Scheduled for head and neck cancer tumor resection and free flap reconstruction surgery
Disqualifiers
Preoperative tracheostomy
History of previous head and neck cancer tumor resection
Anemia (hematocrit <30% or recent transfusion)
Hypertension on ACEI/ARB medications
Trial design
Treatments tested in this trial
- Multimodal analgesia using dexmedetomidine-ketamine-lidocaine mixture
- Minimal flow sevoflurane
Treatment groups
60 Participants
are divided into 4 treatment groupsLocations
This trial has no locations
Sponsors and collaborators
National Taiwan University Hospital
Lead sponsor
Source ClinicalTrials.gov