Ephedrine for Reducing Onset Time of Rocurinium in Elderly Patients
ConditionNeuromuscular Blockade
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age80+
SponsorMatias Vested
About this trial
The aim of this study is to determine the onset time of rocuronium after administration of ephedrine 0.15 mg/kg in patients with age ≥ 80 years. The hypothesis of this study is that ephedrine 0.15 mg/kg provides a shorter onset time compared to placebo (saline).
Eligibility criteria
Qualifiers
Age ≥ 80
Scheduled for elective operations under general anesthesia with intubation
American Society of Anesthesiologists physical status classification (ASA) I to III
Informed consent
Disqualifiers
Known allergy to rocuronium or ephedrine
Neuromuscular disease that may interfere with neuromuscular data
Indication for rapid sequence induction
Daily use of beta-blocking agents
Trial design
Treatments tested in this trial
- Ephedrine Hydrochloride 30 mg/ml
- Saline (NaCl 0,9 %) (placebo)
Treatment groups
80 Participants
are divided into 2 treatment groupsLocations
2Department of Anaesthesiology, Pain and Respiratory Support, Rigshospitalet Glostrup2100, Copenhagen Denmark
Department of Anesthesia, Centre of Head and Orthopedics, 6013 Rigshospitalet2100, Copenhagen Denmark
Sponsors and collaborators
Matias Vested
Lead sponsor
Rigshospitalet, Denmark
Sponsor institution
Source ClinicalTrials.gov