About this trial

Double blind, double dummy trial of the use of IV acetaminophen versus oral acetaminophen for the prevention of delirium after cardiac surgery. The underlying hypothesis is that better pain control and less use of narcotics will lead to a lower incidence of delirium from day 1 to 7 following cardiac surgery. Other important secondary outcomes are the total use of narcotics, ICU and hospital stay, improved cognitive function at 6 months and 1 year post surgery, NSAID use at each centre and associated NSAID complications.

Eligibility criteria

Qualifiers

elective cardiac surgery

stable pre-operative

aorto-coronary bypass with or without 1 valve replacement.

Disqualifiers

None

Trial design

Treatments tested in this trial

  • acetaminophen

Treatment groups

1,100 Participants
are divided into 2 treatment groups

Locations

8
University of British ColumbiaV6T 1Z4, VancouverBritish Columbia, Canada
University of ManitobaR3T2N2, WinnipegManitoba, Canada
Trillium Health CentreL5B2V2, MississaguaOntario, Canada
University of OttawaK1N6N5, OttawaOntario, Canada

Sponsors and collaborators

McGill University Health Centre/Research Institute of the McGill University Health Centre

Lead sponsor

Laval University

Collaborator

University of British Columbia

Collaborator

St. Boniface Hospital

Collaborator

University of Ottawa

Collaborator

Trillium Health Centre

Collaborator

Université de Montréal

Collaborator

Sunnybrook Health Sciences Centre

Collaborator