Limiting perioperative tachycardia (aiming for a heart rate \<90 beats per minute throughout the perioperative period) using the ultra-short acting beta-blocker landiolol in patients with cardiovascular risk factors undergoing major surgery might lower the incidence of perioperative myocardial injury. Feasibility of the intervention needs to be proven prior to conduction of a larger trial.
Patients undergoing elective non-cardiac surgery defined as intermediate or high-risk by the 2022 european society of cardiology (ESC) guidelines
surgery performed under general anesthesia;
expected length of hospital stay ≥ 24 hours;
age ≥ 45 years;
unable to consent or follow study procedures;
absolute contraindications for exercise testing;
pregnancy or intention to become pregnant;
active cardiac conditions (such as unstable coronary syndromes, decompensated heart failure, significant arrhythmias, severe valvular disease);
Insel Gruppe AG, University Hospital Bern
Lead sponsor