[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636743":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":28,"locations":34,"responsibleParty":199,"collaborators":11,"id":203,"slug":11,"hasResults":204,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":11,"eligibilityCriteria":208,"healthyVolunteers":204,"sex":209,"minAge":210,"maxAge":11,"enrollmentInfo":211,"targetDuration":11,"studyType":214,"phases":215,"briefSummary":217,"conditions":218,"keywords":11,"overallStatus":121,"whyStopped":11,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":232},{"fullName":5,"class":6},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental (T-cell Guided Group)","EXPERIMENTAL",null,[13],"Drug: CMV-Specific T-cell Guided Letermovir Discontinuation",{"label":15,"type":16,"description":11,"interventionNames":17},"Active Comparator (Standard Prophylaxis Group)","ACTIVE_COMPARATOR",[18],"Drug: Standard Letermovir Prophylaxis",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","CMV-Specific T-cell Guided Letermovir Discontinuation","Patients receive Letermovir prophylaxis (480 mg\u002Fday orally or IV) according to the standard protocol until approximately 100 days post-transplantation, regardless of T-cell recovery status.",[9],{"type":21,"name":26,"description":23,"armGroupLabels":27,"otherNames":11},"Standard Letermovir Prophylaxis",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":11,"email":33},"wei MD, PhD","CONTACT","+86 027-85726003","shiwei076@hust.edu.cn",[35,53,68,83,94,109,120,132,143,154,169,184],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Chinese PLA General Hospital","NOT_YET_RECRUITING","Beijing","Beijing Municipality","100853","China",{"type":43,"coordinates":44},"Point",[45,46],116.39723,39.9075,{"lat":46,"lon":45},[49],{"name":50,"role":31,"phone":51,"phoneExt":11,"email":52},"Fei Li","+86 18611406860","847982123@qq.com",{"facility":54,"status":37,"city":55,"state":56,"zip":57,"country":41,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"The Second Hospital of Hebei Medical University","Shijiazhuang","Hebei","050000",{"type":43,"coordinates":59},[60,61],114.47861,38.04139,{"lat":61,"lon":60},[64],{"name":65,"role":31,"phone":66,"phoneExt":11,"email":67},"Fuxu Wang","+86 13931100360","827064030@qq.com",{"facility":69,"status":37,"city":70,"state":71,"zip":72,"country":41,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Henan Cancer Hospital","Zhengzhou","Henan","450008",{"type":43,"coordinates":74},[75,76],113.64861,34.75778,{"lat":76,"lon":75},[79],{"name":80,"role":31,"phone":81,"phoneExt":11,"email":82},"Jian Zhou","+86 13623822347","zhoujiandoctor@163.com",{"facility":84,"status":37,"city":70,"state":71,"zip":85,"country":41,"cosmosGeoPoint":86,"geoPoint":88,"contacts":89},"The First Affiliated Hospital of Zhengzhou University","450052",{"type":43,"coordinates":87},[75,76],{"lat":76,"lon":75},[90],{"name":91,"role":31,"phone":92,"phoneExt":11,"email":93},"Weijie Cao","+86 15093360671","caoweijie2003@126.com",{"facility":95,"status":37,"city":96,"state":97,"zip":98,"country":41,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Jingzhou First People's Hospital","Jingzhou","Hubei","434000",{"type":43,"coordinates":100},[101,102],112.19028,30.35028,{"lat":102,"lon":101},[105],{"name":106,"role":31,"phone":107,"phoneExt":11,"email":108},"Jie Tan","+86 18163137226","Tanjie@yangtzeu.edu.cn",{"facility":110,"status":37,"city":96,"state":97,"zip":111,"country":41,"cosmosGeoPoint":112,"geoPoint":114,"contacts":115},"Jingzhou Central Hospital","434020",{"type":43,"coordinates":113},[101,102],{"lat":102,"lon":101},[116],{"name":117,"role":31,"phone":118,"phoneExt":11,"email":119},"Yuanyan Tang","+86 18107168243","343665915@qq.com",{"facility":5,"status":121,"city":122,"state":97,"zip":123,"country":41,"cosmosGeoPoint":124,"geoPoint":128,"contacts":129},"RECRUITING","Wuhan","430022",{"type":43,"coordinates":125},[126,127],114.26667,30.58333,{"lat":127,"lon":126},[130],{"name":131,"role":31,"phone":32,"phoneExt":11,"email":33},"Wei Shi, M.D.",{"facility":133,"status":37,"city":122,"state":97,"zip":134,"country":41,"cosmosGeoPoint":135,"geoPoint":137,"contacts":138},"Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology","430030",{"type":43,"coordinates":136},[126,127],{"lat":127,"lon":126},[139],{"name":140,"role":31,"phone":141,"phoneExt":11,"email":142},"Yang Cao","+86 13986142606","caoyangemma@163.com",{"facility":144,"status":37,"city":122,"state":97,"zip":145,"country":41,"cosmosGeoPoint":146,"geoPoint":148,"contacts":149},"Zhongnan Hospital of Wuhan University","430071",{"type":43,"coordinates":147},[126,127],{"lat":127,"lon":126},[150],{"name":151,"role":31,"phone":152,"phoneExt":11,"email":153},"Fei Chen","+86 13545297071","chenfeiwhu@whu.edu.cn",{"facility":155,"status":37,"city":156,"state":157,"zip":158,"country":41,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"The Affiliated Hospital of Inner Mongolia Medical University","Hohhot","Inner Mongolia","010050",{"type":43,"coordinates":160},[161,162],111.65222,40.81056,{"lat":162,"lon":161},[165],{"name":166,"role":31,"phone":167,"phoneExt":11,"email":168},"Da Gao","+86 13947130473","gaoda72@163.com",{"facility":170,"status":37,"city":171,"state":172,"zip":173,"country":41,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"The First Affiliated Hospital of Nanchang University","Nanchang","Jiangxi","330006",{"type":43,"coordinates":175},[176,177],115.85306,28.68396,{"lat":177,"lon":176},[180],{"name":181,"role":31,"phone":182,"phoneExt":11,"email":183},"Xianbao Huang","+86 18679119505","huangxianbao2017@163.com",{"facility":185,"status":37,"city":186,"state":187,"zip":188,"country":41,"cosmosGeoPoint":189,"geoPoint":193,"contacts":194},"The First Affiliated Hospital of Wenzhou Medical University","Wenzhou","Zhejiang","325000",{"type":43,"coordinates":190},[191,192],120.66682,27.99942,{"lat":192,"lon":191},[195],{"name":196,"role":31,"phone":197,"phoneExt":11,"email":198},"Lan Sun Sun","+86 13587685726","sunlan91@126.com",{"type":200,"investigatorFullName":201,"investigatorTitle":202,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","WeiShi","Chief Physician","100636743",false,"NCT07569653","Letermovir Prophylaxis Duration Guided by CMV-Specific T-cell Monitoring After Allo-HSCT.","A Multicenter, Randomized, Controlled, Open-label Clinical Study to Evaluate the Efficacy and Safety of Letermovir Prophylaxis Duration Guided by Dynamic Monitoring of Specific T-cells for Preventing Cytomegalovirus Infection in Adult Recipients of Allogeneic Hematopoietic Stem Cell Transplantation in China.","Inclusion Criteria:\n\n1. Recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT).\n2. CMV serostatus of the recipient is positive (R+).\n3. Aged 18 years or older.\n4. Expected survival \\> 6 months.\n5. Provision of signed informed consent.\n\nExclusion Criteria:\n\n* 1.Active CMV infection or CMV disease at the time of screening.\n\n  2.Known hypersensitivity to Letermovir or its excipients.\n\n  3.Severe hepatic or renal impairment.\n\n  4.Pregnant or breastfeeding women.","ALL","18 Years",{"count":212,"type":213},120,"ESTIMATED","INTERVENTIONAL",[216],"PHASE4","The purpose of this study is to evaluate the efficacy and safety of a personalized strategy for discontinuing Letermovir (a drug used to prevent Cytomegalovirus \\[CMV\\] infection) based on the recovery of the patient's own immune system.\n\nCytomegalovirus (CMV) is a common and serious complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Currently, Letermovir is typically given as a standard prevention for about 100 days post-transplant. However, some patients may recover their CMV-specific immunity earlier, while others may need longer protection.\n\nIn this study, researchers will use a dynamic monitoring technology (QuantiFERON-CMV) to detect the level of CMV-specific T-cells in patients. Participants will be randomly assigned to either the experimental group or the control group:\n\nExperimental Group: Letermovir discontinuation will be guided by T-cell recovery. If the test shows that the patient's CMV-specific T-cells have recovered, Letermovir may be stopped earlier than the standard 100 days.\n\nControl Group: Patients will receive the standard Letermovir prophylaxis for approximately 100 days, regardless of T-cell status.\n\nThe study aims to determine if this immune-guided strategy can effectively prevent CMV infection while potentially reducing the duration of medication and associated costs, without increasing the risk of CMV disease.",[219,220,221,222],"Cytomegalovirus Infections","Cytomegalovirus Disease","Hematopoietic Stem Cell Transplantation","Graft vs Host Disease","2026-05-27",{"date":225,"type":226},"2026-06-01","ACTUAL",{"date":228,"type":226},"2025-10-30",{"date":230,"type":213},"2027-12",{"name":201,"class":6},12]