LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age65+
SponsorYale University
About this trial
To establish the effectiveness and tolerability of standard of care anti-anginal treatment (beta-blocker and calcium channel blocker medications) in older adults with symptomatic Stable Ischemic Heart Disease (SIHD) and multiple chronic conditions (MCC).
Eligibility criteria
Qualifiers
Age ≥65 years
≥ 2 Multiple Chronic Conditions as defined by Centers for Medicare and Medicaid Services (CMS)
positive non-invasive functional or anatomic testing suggestive of obstructive coronary artery disease
coronary angiography with stenosis ≥70% in a coronary artery ≥2 mm in diameter or
Disqualifiers
Current taking (both) a beta-blocker AND a calcium channel blocker*
significant hypotension
high grade AV block
severe symptomatic bradycardia
Trial design
Treatments tested in this trial
- Clinician Discretion
- Beta blocker
- Calcium channel blocker
Treatment groups
741 Participants
are divided into 2 treatment groupsLocations
10Connecticut
Yale School of Medicine06520, New Haven United States
Georgia
Wellstar Research Institute30060, Marietta United States
Illinois
Cook County Health60612, Chicago United States
Massachusetts
Brigham and Women's Hospital02115, Boston United States
Sponsors and collaborators
Yale University
Lead sponsor
Source ClinicalTrials.gov