[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100569866":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":29,"centralContacts":33,"locations":38,"responsibleParty":58,"collaborators":28,"id":61,"slug":28,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":28,"eligibilityCriteria":65,"healthyVolunteers":62,"sex":66,"minAge":67,"maxAge":28,"enrollmentInfo":68,"targetDuration":28,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":41,"whyStopped":28,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Emory University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Continuous Glucose Monitoring with Adjusted Insulin Doses","EXPERIMENTAL","Patients with ketosis-prone diabetes will wear a continuous glucose monitor (CGM) from the time of hospital discharge until insulin discontinuation. Insulin doses will be adjusted based on CGM glucose readings.",[13,14],"Device: Continuous Glucose Monitoring","Drug: Insulin",[16,23],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DEVICE","Continuous Glucose Monitoring","After insulin discontinuation participants continue wearing their CGMs, for a total of 3 months.",[9],[22],"Freestyle Libre",{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","Insulin","Participants will receive standard-of-care insulin treatment. Insulin dosing will be adjusted based on CGM glucose readings.",[9],null,[30],{"name":31,"affiliation":5,"role":32},"Priyathama Vellanki, MD, MS","PRINCIPAL_INVESTIGATOR",[34],{"name":31,"role":35,"phone":36,"phoneExt":28,"email":37},"CONTACT","(404) 778-1687","priyathama.vellanki@emory.edu",[39,52],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":28},"Grady Health System","RECRUITING","Atlanta","Georgia","30303","United States",{"type":47,"coordinates":48},"Point",[49,50],-84.38798,33.749,{"lat":50,"lon":49},{"facility":53,"status":41,"city":42,"state":43,"zip":54,"country":45,"cosmosGeoPoint":55,"geoPoint":57,"contacts":28},"Emory University Hospital Midtown","30308",{"type":47,"coordinates":56},[49,50],{"lat":50,"lon":49},{"type":32,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"Priyathama Vellanki","Associate Professor","100569866",false,"NCT06699810","Modeling Ketosis-Prone Diabetes Remission Via Diverse Mechanisms of Glucotoxicity","Inclusion Criteria:\n\n* Provide informed consent\n* Have a BMI ≥ 28 kg\u002Fm2\n* Be of African American ancestry\n* Meet diagnostic criteria for DKA. Diagnostic criteria for DKA will include a plasma glucose \\> 250 mg\u002Fdl, a venous pH \\\u003C 7.30, a serum bicarbonate \\\u003C 18 mmol\u002Fl, and serum ketones (beta-hydroxy butyrate) \\> 1.5 mmol\u002FL.\n\nExclusion Criteria:\n\n* Significant medical or surgical illness including but not limited to myocardial ischemia, congestive heart failure, chronic peripheral venous insufficiency, chronic renal insufficiency, liver insufficiency (serum transaminases 3 times the upper limit of normal) and acute or chronic infectious processes\n* Have recognized uncontrolled endocrine disorders such as hypercortisolism, acromegaly, or hyperthyroidism\n* Anemia (hemoglobin \\\u003C 12.5 g\u002FdL for men, \\\u003C11.5 gm\u002FdL for women), bleeding disorders, or abnormalities in coagulation studies\n* Pregnant\n* Diagnosis of diabetes \\> 90 days before the presentation of DKA\n* Unable to give consent","ALL","18 Years",{"count":69,"type":70},12,"ESTIMATED","INTERVENTIONAL",[73],"PHASE4","The goal of this study is to quantify day-to-day changes in blood glucose during treatment towards remission in ketosis-prone diabetes (KPDM) and describe them using a mathematical model of KPDM pathogenesis and remission.",[76],"Ketosis Prone Diabetes",[78,79],"diabetic ketoacidosis","type 2 diabetes","2026-06-12",{"date":82,"type":83},"2026-06-15","ACTUAL",{"date":85,"type":83},"2025-01-23",{"date":87,"type":70},"2027-01",{"name":5,"class":6},2]