[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521806":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":25,"locations":31,"responsibleParty":49,"collaborators":24,"id":52,"slug":24,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":24,"maxAge":59,"enrollmentInfo":60,"targetDuration":24,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":34,"whyStopped":24,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Endeavor Health","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Calfactant (Infasurf)","EXPERIMENTAL","Neonate, 28-35 weeks gestation, less than 48 hours of age, with respiratory distress syndrome on CPAP \\> 30% oxygen will be given 3ml\u002Fkg of Calfacant",[13],"Drug: MIST surfactant",{"label":15,"type":10,"description":16,"interventionNames":17},"Poractant alfa (Curosurf)","Neonate, 28-35 weeks gestation, less than 48 hours of age, with respiratory distress syndrome on CPAP \\> 30% oxygen will be given 2.5ml\u002Fkg of Poractant alfa.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","MIST surfactant","Surfactant will be given via MIST while neonate is on CPAP",[9,15],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},"Matthew Derrick","CONTACT","18475702920","mderrick@northshore.org",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Northshore University Healthsystem","RECRUITING","Evanston","Illinois","60201","United States",{"type":40,"coordinates":41},"Point",[42,43],-87.69006,42.04114,{"lat":43,"lon":42},[46],{"name":47,"role":28,"phone":48,"phoneExt":24,"email":30},"Matthew Derrick, mbbs","8475702920",{"type":50,"investigatorFullName":27,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Attending Neonatologist","100521806",false,"NCT06074380","Non Inferiority Trial Investigating Surfactants Administered Via MIST","Niftisurf","Inclusion Criteria:\n\n* Preterm infants 28-35 6\u002F7 weeks' gestation and less than 48 hours of age who have a clinical diagnosis of respiratory distress syndrome confirmed by a chest x-ray on nasal continuous positive airway pressure (NCPAP) and FiO2 ≥0.30\n\nExclusion Criteria:\n\n* Infants will be excluded if there is a congenital anomaly or an alternative cause for respiratory distress.\n* Infants who require emergent intubation will not be enrolled in the interventions.","ALL","48 Hours",{"count":61,"type":62},262,"ESTIMATED","INTERVENTIONAL",[65],"PHASE4","RESEARCH DESIGN Multicenter, randomized, controlled trial. RECRUITMENT Entry criteria Preterm infants 28-35 6\u002F7 weeks' gestation and less than 48 hours of age who have a clinical diagnosis of respiratory distress syndrome. Infants who are on NCPAP and FiO2 ≥0.30 will randomized to curosurf or infasurf via MIST.\n\nExclusion criteria Infants will be excluded if there is a congenital anomaly or an alternative cause for respiratory distress.\n\nBabies who require emergent intubation will not be enrolled in the interventions.\n\nParental Consent will be obtained prior to randomization.",[68],"Respiratory Distress Syndrome",[70,71,72],"Pulmonary Surfactant","CPAP","Neonate","2025-08-04",{"date":75,"type":76},"2025-08-07","ACTUAL",{"date":78,"type":76},"2024-01-01",{"date":80,"type":62},"2027-12-01",{"name":5,"class":6},1]