[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622859":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":28,"locations":34,"responsibleParty":50,"collaborators":11,"id":54,"slug":11,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":11,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":11,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":11,"overallStatus":37,"whyStopped":11,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Port Said University hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group OFA (Opioid-Free Anesthesia):","ACTIVE_COMPARATOR",null,[13],"Drug: Dexmedetomidine",{"label":15,"type":10,"description":11,"interventionNames":16},"Group OBA (Opioid-Based Anesthesia)",[17],"Drug: Fentanyl (IV)",[19,24],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"DRUG","Dexmedetomidine","patients will Receive dexmedetomidine with a loading dose of 1 μg\u002Fkg followed by a maintenance infusion of 0.5 μg\u002Fkg\u002Fh.",[9],{"type":20,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"Fentanyl (IV)","patients will Receive fentanyl with a loading dose of 1 μg\u002Fkg followed by a maintenance infusion of 0.5 μg\u002Fkg\u002Fh.",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":11,"email":33},"Nashwa gomaa Ahmed, MD","CONTACT","00201005289328","dr_nashwa_2008@yahoo.com",[35],{"facility":36,"status":37,"city":38,"state":11,"zip":39,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Port said university","RECRUITING","Port Said","42111","Egypt",{"type":42,"coordinates":43},"Point",[44,45],32.3019,31.26531,{"lat":45,"lon":44},[48],{"name":49,"role":31,"phone":32,"phoneExt":11,"email":33},"nashwa gomaa ahmed, MD",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Nashwa Ahmed",", Lecturer of Anaesthesia and Surgical Intensive Care, Faculty of Medicine, Port Said University, Egypt","100622859",false,"NCT07389096","Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis","Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis A Prospective Randomized Double-Blind Controlled Trial","Inclusion Criteria:Patients younger than 18 years of age, classified as American Society of Anesthesiologists (ASA) Physical Status I or II, and will be scheduled for surgical correction of adolescent idiopathic scoliosis.\n\n\\-\n\nExclusion Criteria:• Refusal to participate in the study or to allow use of personal data\n\n* Non-idiopathic scoliosis\n* Contraindications to commonly used perioperative medications\n* ASA Physical Status ≥ III\n* Presence of neuromuscular disorders or severe cardiac dysfunction\n* Requirement for postoperative mechanical ventilation\n* Regular use of analgesics or opioids\n* History of allergy to opioids or dexmedetomidine\n* Diagnosed mental disorders\n* Severe hepatic or renal dysfunction\n* Coagulopathy or significant pulmonary disease\n* Preoperative or postoperative neurological deficits\n* Occurrence of serious arrhythmia, hypotension, or bradycardia necessitating discontinuation of dexmedetomidine infusion","ALL","8 Years","18 Years",{"count":64,"type":65},30,"ESTIMATED","INTERVENTIONAL",[68],"PHASE4","Opioid-free anesthesia (OFA) is a multimodal analgesic approach designed to eliminate the intraoperative use of systemic, neuraxial, or intracavitary opioids. This technique employs a combination of antinociceptive agents targeting various pathways within the central and peripheral nervous systems to achieve effective analgesia.\n\nDexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist, is a centrally acting non-opioid agent increasingly utilized in clinical practice for its antinociceptive and anxiolytic properties. Only a few prospective randomized controlled trials have specifically examined the postoperative analgesic efficacy of intraoperative dexmedetomidine infusion in patients undergoing spinal surgery, with limited data focusing on this as a primary endpoint. Importantly, no clinical studies have investigated its analgesic impact in patients undergoing spinal surgery under general anesthesia.",[71],"Opioid Free Anesthesia","2026-01-30",{"date":74,"type":75},"2026-02-05","ACTUAL",{"date":72,"type":65},{"date":78,"type":65},"2027-01-31",{"name":52,"class":6},1]