[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100490700":3},{"organization":4,"armGroups":7,"interventions":75,"overallOfficials":90,"centralContacts":94,"locations":104,"responsibleParty":120,"collaborators":99,"id":123,"slug":99,"hasResults":124,"nctId":125,"briefTitle":126,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":124,"sex":129,"minAge":130,"maxAge":99,"enrollmentInfo":131,"targetDuration":99,"studyType":134,"phases":135,"briefSummary":137,"conditions":138,"keywords":141,"overallStatus":107,"whyStopped":99,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":158},{"fullName":5,"class":6},"University of Connecticut","OTHER",[8,15,20,24,28,32,36,40,44,48,52,56,60,64,68,71],{"label":9,"type":10,"description":11,"interventionNames":12},"Condition 1","ACTIVE_COMPARATOR","Standard CHRP Intervention Components",[13,14],"Behavioral: community-friendly health recovery program","Drug: Pre-Exposure Prophylaxis and Post-Exposure Prophylaxis",{"label":16,"type":17,"description":18,"interventionNames":19},"Condition 2","EXPERIMENTAL","Standard CHRP Intervention Components and Information Processing Components",[13,14],{"label":21,"type":17,"description":22,"interventionNames":23},"Condition 3","Standard CHRP Intervention Components and Memory Components",[13,14],{"label":25,"type":17,"description":26,"interventionNames":27},"Condition 4","Standard CHRP Intervention Components, Information Processing Components, and Memory Components",[13,14],{"label":29,"type":17,"description":30,"interventionNames":31},"Condition 5","Standard CHRP Intervention Components, Executive Functioning Components",[13,14],{"label":33,"type":17,"description":34,"interventionNames":35},"Condition 6","Standard CHRP Intervention Components, Information Processing Components, and Executive Functioning Components",[13,14],{"label":37,"type":17,"description":38,"interventionNames":39},"Condition 7","Standard CHRP Intervention Components, Memory Components, and Executive Functioning Components",[13,14],{"label":41,"type":17,"description":42,"interventionNames":43},"Condition 8","Standard CHRP Intervention Components, Information Processing Components, Memory Components, and Executive Functioning Components",[13,14],{"label":45,"type":17,"description":46,"interventionNames":47},"Condition 9","Standard CHRP Intervention Components and Attention Components",[13,14],{"label":49,"type":17,"description":50,"interventionNames":51},"Condition 10","Standard CHRP Intervention Components, Information Processing Components, and Attention Components",[13,14],{"label":53,"type":17,"description":54,"interventionNames":55},"Condition 11","Standard CHRP Intervention Components, Memory Components, and Attention Components",[13,14],{"label":57,"type":17,"description":58,"interventionNames":59},"Condition 12","Standard CHRP Intervention Components, Information Processing Components, Memory Components, and Attention Components",[13,14],{"label":61,"type":17,"description":62,"interventionNames":63},"Condition 13","Standard CHRP Intervention Components, Executive Functioning Components, and Attention Components",[13,14],{"label":65,"type":17,"description":66,"interventionNames":67},"Condition 14","Standard CHRP Intervention Components, Executive Functioning Components, Attention Components, and Information Processing Components",[13,14],{"label":69,"type":17,"description":66,"interventionNames":70},"Condition 15",[13,14],{"label":72,"type":17,"description":73,"interventionNames":74},"Condition 16","Standard CHRP Intervention Components, Executive Functioning Components, Attention Components, Information Processing Components, and Memory Components",[13,14],[76,83],{"type":77,"name":78,"description":79,"armGroupLabels":80,"otherNames":81},"BEHAVIORAL","community-friendly health recovery program","Participants will receive 4 weekly 45 minute sessions HIV prevention sessions.",[9,49,53,57,61,65,69,72,16,21,25,29,33,37,41,45],[82],"CHRP",{"type":84,"name":85,"description":86,"armGroupLabels":87,"otherNames":88},"DRUG","Pre-Exposure Prophylaxis and Post-Exposure Prophylaxis","Participants will be prescribed Pre-exposure prophylaxis (PrEP) is a biomedical intervention.",[9,49,53,57,61,65,69,72,16,21,25,29,33,37,41,45],[89],"PrEP",[91],{"name":92,"affiliation":5,"role":93},"Michael Copenhaver, PhD","PRINCIPAL_INVESTIGATOR",[95,101],{"name":96,"role":97,"phone":98,"phoneExt":99,"email":100},"Brian Sibilio, BS","CONTACT","2037814690",null,"brian.sibilio@uconn.edu",{"name":102,"role":97,"phone":98,"phoneExt":99,"email":103},"Tanya Adler, MS","tanya.adler@uconn.edu",[105],{"facility":106,"status":107,"city":108,"state":109,"zip":110,"country":111,"cosmosGeoPoint":112,"geoPoint":117,"contacts":118},"APT Foundation","RECRUITING","New Haven","Connecticut","06519","United States",{"type":113,"coordinates":114},"Point",[115,116],-72.92816,41.30815,{"lat":116,"lon":115},[119],{"name":96,"role":97,"phone":98,"phoneExt":99,"email":100},{"type":93,"investigatorFullName":121,"investigatorTitle":122,"investigatorAffiliation":5,"oldNameTitle":99,"oldOrganization":99},"Michael Copenhaver","Professor","100490700",false,"NCT05669534","Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP","MOST","Inclusion Criteria:\n\n* being 18 years or older\n* meeting DSM-V criteria for opioid dependence and being newly prescribed and adherent to Medication for Opioid Use Disorder (e.g., methadone, buprenorphine) at the APT Foundation, Inc.\n* showing mild cognitive impairment based on the Montreal Cognitive Assessment (MoCA) screening\n* having initiated Pre-Exposure Prophylaxis (PrEP) within the past week\n* confirming HIV-negative status through proof of PrEP prescription\n* reporting unsafe injection drug use practices or unprotected sex within the past 3 months\n* having a cell phone\n* being able to read and understand in English\n\nExclusion Criteria:\n\n* unable to provide consent\n* actively suicidal\n* actively homicidal\n* actively psychotic\n* display MoCA scores suggestive of dementia","ALL","18 Years",{"count":132,"type":133},256,"ESTIMATED","INTERVENTIONAL",[136],"PHASE4","The investigators will conduct an optimization trial among N=256 PWID newly started on medication for opioid use disorder and Pre-Exposure Prophylaxis (PrEP) to assess the performance of four intervention components (Attention, Executive Functioning, Memory, and Information Processing) aimed at enhancing the ability of PWID on MOUD to process and utilize HIV prevention content, leading to improvements in HIV prevention information, motivation, behavioral skills, and behaviors (IMB).",[139,140],"Hiv","Opioid Use Disorder",[142,143,144,145,146,147,148],"people who inject drugs","HIV","cognitive dysfunction","pre-exposure prophylaxis","multiphase optimization strategy","medication for opioid use disorder","opioid use disorder","2026-06-12",{"date":151,"type":152},"2026-06-15","ACTUAL",{"date":154,"type":152},"2023-03-01",{"date":156,"type":133},"2027-01-01",{"name":5,"class":6},1]