Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorInstitute for Clinical and Experimental Medicine
About this trial
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients with acutely decompensated heart failure with reduced left ventricular ejection fraction.
Eligibility criteria
Qualifiers
LVEF <35%
Acute heart failure with low cardiac output syndrome or cardiogenic shock
Disqualifiers
Severe liver failure
Severe acidosis
Inability to insert nasogastric tube
Gastric paralysis / ileus
Trial design
Treatments tested in this trial
- Ketone Monoester (KE)
Treatment groups
12 Participants
are divided into 1 treatment groupLocations
1Institute for Clinical and Experimental Medicine (IKEM)14021, PraguePrague, Czechia
Sponsors and collaborators
Institute for Clinical and Experimental Medicine
Lead sponsor
Source ClinicalTrials.gov