Health Trials

About this trial

This randomized clinical trial aims to evaluate the effectiveness of two medications-hydrocortisone ointment and lidocaine solution-applied to the endotracheal tube in reducing postoperative throat pain, hoarseness, and cough following thyroid or parathyroid surgery with neuromonitoring.

A total of 764 adult patients undergoing elective neck surgery at Saint-Petersburg State University Hospital will be enrolled and randomly assigned to receive either a hydrocortisone-coated or lidocaine-coated endotracheal tube.

Outcomes will be assessed upon awakening from anesthesia, at 24 hours, and again at 3 days postoperatively.

The findings may contribute to improving postoperative comfort and recovery for patients undergoing similar surgical procedures.

Eligibility criteria

Qualifiers

Patients scheduled for elective open surgery on the thyroid/parathyroid glands with intraoperative neuromonitoring.

Age ≥18 years.

Willing and able to provide voluntary informed consent for participation in the study.

Disqualifiers

Pregnancy (for women of childbearing potential).

Known allergy to hydrocortisone or lidocaine.

Refusal to participate in the study.

Trial design

Treatments tested in this trial

  • Hydrocortisone Acetate 1% Ointment
  • Lidocaine hydrochloride 0,05% with chlorhexidine

Treatment groups

764 Participants
are divided into 2 treatment groups

Locations

1
Saint Petersburg State University Hospital Saint Petersburg Russia

Sponsors and collaborators

Saint Petersburg State University, Russia

Lead sponsor

Smooth Drug Development

Collaborator

Source ClinicalTrials.gov