[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623423":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":39,"responsibleParty":104,"collaborators":108,"id":116,"slug":18,"hasResults":117,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":117,"sex":123,"minAge":124,"maxAge":125,"enrollmentInfo":126,"targetDuration":18,"studyType":129,"phases":130,"briefSummary":132,"conditions":133,"keywords":18,"overallStatus":42,"whyStopped":18,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":148},{"fullName":5,"class":6},"Universiti Sains Malaysia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Honey group","ACTIVE_COMPARATOR","Subjects will be provided stingless bee honey packeted in sachets of 30g. They are required to consume 30gram of honey per day for a total of 90 days duration.",[13],"Biological: Stingless bee honey (Kelulut)",{"label":15,"type":16,"description":17,"interventionNames":18},"Non-honey group","NO_INTERVENTION","Subjects in this group will not receive honey. Subjects will undergo comprehensive ophthalmic examination and blood taking for measurement of serum Interleukin-6 level before and after the duration of study.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BIOLOGICAL","Stingless bee honey (Kelulut)","Kelulut is stingless bee honey, a natural biologic product produced by stinglee bee species.",[9],[26],"Kelulut",[28],{"name":29,"affiliation":5,"role":30},"Azhany Yaakub, MD, MMed, PhD","STUDY_DIRECTOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},"Thamarai Munirathinam, MD(Prague)","CONTACT","+60177712935","nitaraicz88@gmail.com",{"name":29,"role":34,"phone":18,"phoneExt":18,"email":38},"azhany@usm.my",[40,59,74,88],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Hospital Raja Perempuan Zainab II","RECRUITING","Kota Bharu","Kelantan","15586","Malaysia",{"type":48,"coordinates":49},"Point",[50,51],102.24333,6.12361,{"lat":51,"lon":50},[54,58],{"name":55,"role":34,"phone":56,"phoneExt":18,"email":57},"Munira Yusoff, Masters of Ophthamology","+60139812116","drmyusoff@gmail.com",{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},{"facility":60,"status":42,"city":61,"state":44,"zip":62,"country":46,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Hospital Sultan Ismail Petra","Kuala Krai","18000",{"type":48,"coordinates":64},[65,66],102.19925,5.5313,{"lat":66,"lon":65},[69,73],{"name":70,"role":34,"phone":71,"phoneExt":18,"email":72},"Norihan Ibrahim, Masters of Ophthamology","+60196610635","norihanibrahim13@gmail.com",{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},{"facility":75,"status":42,"city":76,"state":44,"zip":77,"country":46,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"Hospital Universiti Sains Malaysia","Kubang Kerian","16150",{"type":48,"coordinates":79},[80,81],102.27938,6.09123,{"lat":81,"lon":80},[84,86],{"name":85,"role":34,"phone":35,"phoneExt":18,"email":36},"Thamarai Munirathinam, Doctor of Medicine",{"name":87,"role":34,"phone":18,"phoneExt":18,"email":38},"Azhany Yaakub, MD (USM), MMed (Ophthal), PhD",{"facility":89,"status":42,"city":90,"state":91,"zip":92,"country":46,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"Hospital Sultanah Nur Zahirah","Kuala Terengganu","Terengganu","20400",{"type":48,"coordinates":94},[95,96],103.1408,5.3302,{"lat":96,"lon":95},[99,103],{"name":100,"role":34,"phone":101,"phoneExt":18,"email":102},"Anita Che Omar, Masters of Ophthamology","+60139221105","drnoranita@moh.gov.my",{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},{"type":105,"investigatorFullName":106,"investigatorTitle":107,"investigatorAffiliation":75,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Thamarai Munirathinam","Doctor of Medicine (MD), Medical Officer, Prinicipal Investigator, Department of Ophthalmology,",[109,112,115],{"name":110,"class":111},"Hospital Raja Perempuan Zainab II, Kota Bahru, Kelantan","UNKNOWN",{"name":113,"class":114},"Hospital Sultanah Nur Zahirah, Kuala Terengganu","OTHER_GOV",{"name":75,"class":6},"100623423",false,"NCT07396441","Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye","Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye.","HONEY-JOAG","Inclusion Criteria:\n\nJOAG patients age 15 years old and above until 40 years old at the time of diagnosis Compliant to conventional treatment achieved target intraocular pressure\n\nExclusion Criteria:\n\nPatients with allergy to honey or honey-based products OCT signal less than 6\u002F10 Concurrent retinal diseases and other optic neuropathies Systemic neurodegenerative disease Systemic comorbidities such as diabetes mellitus and autoimmune diseases Patients on other honey-based products for the last 3 months Patient who consumes honey-based products during the study duration of 3 months (monitoring via honey-diary, return of the used sachet during the follow up visits) Patients on anti-oxidants, traditional medications or herbal products for the last 3 months Topical usage of steroids, systemic steroids and non-steroidal anti-inflammatory drugs.\n\nSepsis Compliance less than 75%.","ALL","15 Years","40 Years",{"count":127,"type":128},60,"ESTIMATED","INTERVENTIONAL",[131],"PHASE4","The goal of this clinical trial is to evaluate the effects of stingless bee honey (Kelulut honey) in juvenile open-angle glaucoma patients. The study evaluates the effects on serum Interleukin 6 level(IL-6), retinal nerve fiber layer(RNFL) thickness and dry eye-related symptoms. A total of 60 participants who meet the study criteria will be randomly assigned to one of two groups. One group will consume 30 grams of Kelulut honey daily for a period of three months, while the control group will not receive honey or a placebo. Serum IL-6 level, RNFL thickness, Tear break up time (TBUT) and Schirmer Test 1 will be done before and after 90 days. Adherence to honey consumption will be monitored using a daily diary. This study aims to provide better understanding of the potential role of Kelulut honey as a supplementary therapy in patients with juvenile open-angle glaucoma.",[134,135,136,137,138],"Juvenile Open Angle Glaucoma","Dry Eye Disease (DED)","Interleukin 6","Retinal Nerve Fiber Layer Thickness","HbA1c Level","2026-02-03",{"date":141,"type":142},"2026-02-09","ACTUAL",{"date":144,"type":142},"2026-01-15",{"date":146,"type":128},"2026-06-30",{"name":5,"class":6},4]