[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613506":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":19,"responsibleParty":30,"collaborators":19,"id":32,"slug":19,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":19,"eligibilityCriteria":37,"healthyVolunteers":33,"sex":38,"minAge":39,"maxAge":40,"enrollmentInfo":41,"targetDuration":19,"studyType":44,"phases":45,"briefSummary":47,"conditions":48,"keywords":19,"overallStatus":53,"whyStopped":19,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":19},{"fullName":5,"class":6},"Southern College of Optometry","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"acoltremon","EXPERIMENTAL","Switching to acoltremon 0.003% will significantly improve the signs and symptoms of participants who were being treated with Xiidra at 28 days post-treatment compared to baseline.",[13],"Drug: acoltremon 0.003%",[15],{"type":16,"name":17,"description":11,"armGroupLabels":18,"otherNames":19},"DRUG","acoltremon 0.003%",[9],null,[21,26],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Chris Lievens, OD","CONTACT","901-722-3330","clievens@sco.edu",{"name":27,"role":23,"phone":28,"phoneExt":19,"email":29},"Quentin Franklin, BS, BA","6592064188","QuentinFranklin@uab.edu",{"type":31,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100613506",false,"NCT07267481","Switching From Xiidra to TRYPTYR","Efficacy of Switching Participants Treated With Xiidra to TRYPTYR","Inclusion Criteria:\n\n* Adults ≥18 years of age.\n* Have a history of DED for at least the past 6 months.\n* Are currently using Xiidra as directed by their eye care provider for ≥1 month.\n* Are symptomatic as determined with SPEED (≥7) and have an abnormal Schirmer test score \\[≥2 to \\\u003C10 mm\u002F5 min\\]) at Screening\u002FBaseline. If Shirmer only qualifies for one eye, that will be the study eye. If Shirmer qualifies for both eyes, the right eye will be the study eye.\n* Have corrected distance visual acuity of 20\u002F40 or better.\n* Willing to discontinue contact lens wear 24 hours prior to screening visit and throughout the study.\n\nExclusion Criteria:\n\n* Have a systemic health condition that is known to alter tear film physiology (e.g., primary and secondary Sjögren's syndrome).\n* Have a history of ocular surgery within the past 12 months.\n* Have a history of severe ocular trauma, active ocular infection or inflammation that is not dry eye related.\n* Punctal plugs in place for \\\u003C 3 months and\u002For Lacrifill in place for \\> 5 months.\n* Have ever used Accutane\n* Currently using ocular medications, including topical anti-inflammatory drops, (other than Xiidra) 1 month prior to enrollment\n* Any artificial tear use at enrollment must remain consistent throughout the study.\n* Are pregnant or breast feeding.\n* Have had a physical meibomian gland treatment withing 1 month of enrollment.\n* Initiated, discontinued or changed dose of a systemic medication known to cause ocular drying (e.g., antihistamines or tricyclic antidepressants) within 14 days of the screening visit.\n* Have a condition or be in a situation, which in the investigator's opinion, may put the participant at significant risk, may confound the results, or may significantly interfere with their study participation.","ALL","18 Years","99 Years",{"count":42,"type":43},100,"ESTIMATED","INTERVENTIONAL",[46],"PHASE4","To determine the efficacy of switching participants who are being treated with Xiidra to acoltremon 0.003%.\n\nHypothesis: Switching to acoltremon 0.003% will greatly improve the signs and symptoms of participants who were being treated with Xiidra at 28 days post-treatment compared to baseline.",[49,50,51,52],"Dry Eye","Dry Eyes Chronic","Dry Eye Syndromes","Eye Diseases","NOT_YET_RECRUITING","2025-11-25",{"date":56,"type":57},"2025-12-05","ACTUAL",{"date":59,"type":43},"2025-12-15",{"date":61,"type":43},"2026-05-01",{"name":5,"class":6}]