[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573247":3},{"organization":4,"outcomesModule":7,"designInfo":45,"detailedDescription":11,"studyPopulation":11,"armGroups":55,"interventions":66,"overallOfficials":11,"centralContacts":74,"locations":80,"responsibleParty":97,"collaborators":11,"id":99,"slug":11,"hasResults":100,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":11,"eligibilityCriteria":104,"healthyVolunteers":100,"sex":105,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":11,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":11,"overallStatus":83,"whyStopped":11,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"The Second Affiliated Hospital of Chongqing Medical University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"The incidence of chronic postsurgical pain",null,"from the end of surgery to 3 months after surgery",[14,18,21,23,26,28,31,35,39,42],{"measure":15,"description":16,"timeFrame":17},"The incidence of acute postoperative pain with a score ≥4","Use pain Numeric Rating Scale(NRS) to evaluate the movement-evoked pain score and rest pain score. (NRS scale 0-10, where 0 was no pain, and 10 was the worst possible pain)","from the end of surgery to 6 hours,12 hours, 24 hours , 48 hours and 72 hours after surgery.",{"measure":19,"description":20,"timeFrame":17},"The severity of acute postoperative pain","Use pain Numeric Rating Scale(NRS) to evaluate the movement-evoked pain score and rest pain score.(NRS scale 0-10, where 0 was no pain, and 10 was the worst possible pain)",{"measure":22,"description":20,"timeFrame":12},"The severity of chronic postsurgical pain",{"measure":24,"description":25,"timeFrame":12},"The incidence of neuropathic pain","The DN4 questionnaire (Douleur Neuropathique 4) was used to evaluate neuropathic pain. The DN4 is a validated diagnostic tool consisting of 10 items, with scores ranging from 0 to 10. A score of 4 or higher indicates the presence of neuropathic pain.",{"measure":27,"description":11,"timeFrame":17},"The frequency of postoperative rescue analgesic use",{"measure":29,"description":11,"timeFrame":30},"The dose of analgesic use","from the end of surgery to 6 hours,12 hours, 24 hours and 48 hours after surgery.",{"measure":32,"description":33,"timeFrame":34},"The quality of recovery score at 3 days Postoperatively","The QoR-15 scale, ranging from 0 to 150 with higher scores indicating better recovery, was used to assess the quality of recovery on postoperative day 3.","from the end of surgery to 3 days.",{"measure":36,"description":37,"timeFrame":38},"Health related quality of life score at 3 months Postoperatively","The SF-8 scale, with a scoring range of 0 to 100 where higher scores indicate better physical and mental health, was used to evaluate health-related quality of life at 3 months postoperatively.","from the end of surgery to 3 months after surgery.",{"measure":40,"description":11,"timeFrame":41},"Postoperative length of hospital stay","from end of surgery to about 3 to 7 days after surgery.",{"measure":43,"description":11,"timeFrame":44},"The incidence of adverse reactions","From admission to 3 month post-discharge",{"allocation":46,"interventionModel":47,"interventionModelDescription":11,"primaryPurpose":48,"observationalModel":11,"timePerspective":11,"maskingInfo":49},"RANDOMIZED","PARALLEL","PREVENTION",{"masking":50,"maskingDescription":11,"whoMasked":51},"TRIPLE",[52,53,54],"PARTICIPANT","INVESTIGATOR","OUTCOMES_ASSESSOR",[56,61],{"label":57,"type":58,"description":11,"interventionNames":59},"Coenzyme Q10","EXPERIMENTAL",[60],"Drug: Coenzyme Q10",{"label":62,"type":63,"description":11,"interventionNames":64},"Placebo","PLACEBO_COMPARATOR",[65],"Other: Placebo",[67,71],{"type":68,"name":57,"description":69,"armGroupLabels":70,"otherNames":11},"DRUG","Coenzyme Q10 was administered from admission to one month after discharge at a dose of 200 mg per day (200 mg\u002Fqd).",[57],{"type":6,"name":62,"description":72,"armGroupLabels":73,"otherNames":11},"The placebo was administered from hospital admission until one month after discharge.",[62],[75],{"name":76,"role":77,"phone":78,"phoneExt":11,"email":79},"Guangyou Duan, ph.D","CONTACT","(+86)18323376014","duangy@hospital.cqmu.edu.cn",[81],{"facility":82,"status":83,"city":84,"state":85,"zip":86,"country":87,"countryCode":88,"cosmosGeoPoint":89,"geoPoint":94,"contacts":95},"Guangyou Duan","RECRUITING","Chongqing","Chongqing Municipality","400010","China","CN",{"type":90,"coordinates":91},"Point",[92,93],106.55771,29.56026,{"lat":93,"lon":92},[96],{"name":82,"role":77,"phone":78,"phoneExt":11,"email":79},{"type":98,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100573247",false,"NCT06743802","The Effect of Coenzyme Q10 in Preventing Pain After Thoracoscopic Surgery","The Effect of Coenzyme Q10 in Preventing Pain After Thoracoscopic Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 18-75 years;\n* American Society of Anesthesiology (ASA) physical status classification I-III;\n* Scheduled for elective lung resection surgery under thoracoscopy;\n* Voluntarily opting for patient-controlled intravenous analgesia;\n* Willing to participate in this trial after consultation with the patient or their family and signing the informed consent form.\n\nExclusion Criteria:\n\n* History of previous thoracotomy or thoracoscopic surgery;\n* Patients converted to open thoracotomy intraoperatively;\n* Severe hepatic or renal dysfunction;\n* History of substance abuse;\n* Pregnancy or breastfeeding;\n* History of chronic pain;\n* Use of coenzyme Q10 for more than one month;\n* Allergy to coenzyme Q10;\n* Patients unable to communicate or cooperate.","ALL","18 Years","75 Years",{"count":109,"type":110},264,"ESTIMATED","INTERVENTIONAL",[113],"PHASE4","This study aimed to assess the effectiveness of Coenzyme Q10 in preventing both acute and chronic pain following thoracoscopic surgery, with a focus on its potential benefits in reducing the incidence and severity of pain.",[116],"Postoperative Pain","2025-02-25",{"date":119,"type":120},"2025-02-26","ACTUAL",{"date":122,"type":120},"2025-01-09",{"date":124,"type":110},"2026-03-20",{"name":5,"class":6},1]