The Impact of Dietary Salt on the Severity of Eczema

Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of California, San Francisco

About this trial

The goal of this clinical trial is to evaluate the feasibility of low-sodium diet to improve eczema severity. The main questions it aims to answer are:

* Does a low-sodium diet improve eczema severity? * How does a low-sodium diet impact skin sodium concentration? * Is skin sodium concentration associated with eczema severity?

Researchers will ask all participant to follow a low-sodium diet, then compare sodium tablets to a placebo (a look-alike substance that contains no drug) to specifically examine the impact of altering sodium intake.

Participants will:

* Follow a low-salt diet for the duration of the 24-week study * Take sodium chloride tablets every day for 5 weeks followed by a placebo every day for 5 weeks after a 2-week washout period, or vice versa * Complete up to 4 virtual check-in visits * Visit the clinic 4 times to answer questionnaires, provide bio samples, complete dietary recalls, and undergo non-contrast sodium MRI

Eligibility criteria

Qualifiers

Participants ages 18 years

Willing and able to undergo non-contrast MRI.

Disqualifiers

Contraindications to MRI (such as cardiac pacemakers, claustrophobia, non-compatible intracranial vascular clips, IUDs, or other implants)

A cardiac event in the past 6 months

Impaired function of the liver or kidney (glomerular filtration rate <60 mL/min)

Medications that influence sodium excretion (e.g., diuretics or SGLT2 inhibitors)

Trial design

Treatments tested in this trial

  • Sodium chloride tablets
  • Placebo Tablets

Treatment groups

40 Participants
are divided into 2 treatment groups

Locations

2
San Francisco VA Medical Center94115, San FranciscoCalifornia, United States
UCSF Mt Zion Campus94511, San FranciscoCalifornia, United States

Sponsors and collaborators

University of California, San Francisco

Lead sponsor

United States Department of Defense

Collaborator