[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100578955":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":35,"responsibleParty":431,"collaborators":18,"id":433,"slug":18,"hasResults":434,"nctId":435,"briefTitle":436,"officialTitle":437,"acronym":438,"eligibilityCriteria":439,"healthyVolunteers":434,"sex":440,"minAge":441,"maxAge":18,"enrollmentInfo":442,"targetDuration":18,"studyType":445,"phases":446,"briefSummary":448,"conditions":449,"keywords":451,"overallStatus":456,"whyStopped":18,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":461,"completionDateStruct":463,"leadSponsor":465,"locationsCount":466},{"fullName":5,"class":6},"University Hospital, Toulouse","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Stopping dupilumab","EXPERIMENTAL","The experimental strategy comprises stopping dupilumab with no dose-reducing or interval of time-increasing strategy from the day of inclusion\u002Frandomisation",[13],"Drug: Stopping dupilumab",{"label":15,"type":16,"description":17,"interventionNames":18},"Dupilumab continuation","NO_INTERVENTION","Dupilumab continuation at the same dose and same interval as baseline",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"DRUG","Stopping dupilumab with no dose-reducing or interval of time-increasing strategy",[9],[25],{"name":26,"affiliation":5,"role":27},"Laurent GUILLEMINAULT, MD, PhD","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":33,"email":34},"Laurent GUILLEMINAULT, Md, PhD","CONTACT","0567771850","+33","guilleminault.l@chu-toulouse.fr",[36,49,63,77,91,105,119,133,147,161,175,189,198,212,226,240,254,268,282,293,304,318,332,347,361,375,389,403,417],{"facility":37,"status":18,"city":38,"state":37,"zip":39,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"CHU de Toulouse","Toulouse","31059","France",{"type":42,"coordinates":43},"Point",[44,45],1.44367,43.60426,{"lat":45,"lon":44},[48],{"name":26,"role":31,"phone":32,"phoneExt":33,"email":34},{"facility":50,"status":18,"city":51,"state":40,"zip":52,"country":40,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"CHU Amiens-Picardie","Amiens","80480",{"type":42,"coordinates":54},[55,56],2.3,49.9,{"lat":56,"lon":55},[59],{"name":60,"role":31,"phone":61,"phoneExt":33,"email":62},"Claire ANDREJAK, MD, PhD","0322087893","andrejak.claire@chu-amiens.fr",{"facility":64,"status":18,"city":65,"state":40,"zip":66,"country":40,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"CHR d'Angers","Angers","49100",{"type":42,"coordinates":68},[69,70],-0.55202,47.47156,{"lat":70,"lon":69},[73],{"name":74,"role":31,"phone":75,"phoneExt":33,"email":76},"Yasmina PASCAUD MANSOUR, MD","0245353461","yasmina.mansour@chu-angers.fr",{"facility":78,"status":18,"city":79,"state":40,"zip":80,"country":40,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"CH de Bayonne","Bayonne","64100",{"type":42,"coordinates":82},[83,84],-1.473,43.49316,{"lat":84,"lon":83},[87],{"name":88,"role":31,"phone":89,"phoneExt":33,"email":90},"Cécilia NOCENT, MD","0559443852","cnocent@ch-cotebasque.fr",{"facility":92,"status":18,"city":93,"state":40,"zip":94,"country":40,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"CHU de Besançon","Besançon","25000",{"type":42,"coordinates":96},[97,98],6.01815,47.24878,{"lat":98,"lon":97},[101],{"name":102,"role":31,"phone":103,"phoneExt":33,"email":104},"Cindy BARNIG, MD, PhD","0647737530","cbarnig@chu-besancon.fr",{"facility":106,"status":18,"city":107,"state":40,"zip":108,"country":40,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"CHU de Brest","Brest","29200",{"type":42,"coordinates":110},[111,112],-4.48628,48.39029,{"lat":112,"lon":111},[115],{"name":116,"role":31,"phone":117,"phoneExt":33,"email":118},"Françis COUTURAUD, MD, PhD","0298347347","francis.couturaud@chu-brest.fr",{"facility":120,"status":18,"city":121,"state":40,"zip":122,"country":40,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"CHU de Caen","Caen","14000",{"type":42,"coordinates":124},[125,126],-0.35912,49.18585,{"lat":126,"lon":125},[129],{"name":130,"role":31,"phone":131,"phoneExt":33,"email":132},"Helen FOUQUET, MD","0231064677","fouquet-h@chu-caen.fr",{"facility":134,"status":18,"city":135,"state":40,"zip":136,"country":40,"cosmosGeoPoint":137,"geoPoint":141,"contacts":142},"CH de Cannes","Cannes","06400",{"type":42,"coordinates":138},[139,140],7.01275,43.55135,{"lat":140,"lon":139},[143],{"name":144,"role":31,"phone":145,"phoneExt":33,"email":146},"Fabien ROLLAND, MD","0493697860","f.rolland@ch-cannes.fr",{"facility":148,"status":18,"city":149,"state":40,"zip":150,"country":40,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"CHU de Clermont-Ferrand","Clermont-Ferrand","63000",{"type":42,"coordinates":152},[153,154],3.08682,45.77969,{"lat":154,"lon":153},[157],{"name":158,"role":31,"phone":159,"phoneExt":33,"email":160},"Camille ROLLAND-DEBORD, MD","0473751653","crollanddebord@chu-clermontferrand.fr",{"facility":162,"status":18,"city":163,"state":40,"zip":164,"country":40,"cosmosGeoPoint":165,"geoPoint":169,"contacts":170},"CHI de Créteil","Créteil","94000",{"type":42,"coordinates":166},[167,168],2.46569,48.79266,{"lat":168,"lon":167},[171],{"name":172,"role":31,"phone":173,"phoneExt":33,"email":174},"Amel BOUDJEMAA, MD","0157022080","amel.boudjemaa@chicreteil.fr",{"facility":176,"status":18,"city":177,"state":40,"zip":178,"country":40,"cosmosGeoPoint":179,"geoPoint":183,"contacts":184},"CHU de Dijon","Dijon","21000",{"type":42,"coordinates":180},[181,182],5.01391,47.31344,{"lat":182,"lon":181},[185],{"name":186,"role":31,"phone":187,"phoneExt":33,"email":188},"Philippe BONNIAUD, MD, PhD","0380293772","philippe.bonniaud@chu-dijon.fr",{"facility":190,"status":18,"city":191,"state":40,"zip":192,"country":40,"cosmosGeoPoint":18,"geoPoint":18,"contacts":193},"CH Annecy Genevois","Epagny-Metz-Annecy","74370",[194],{"name":195,"role":31,"phone":196,"phoneExt":33,"email":197},"Toufik DIDI, MD","0450636603","tdidi@ch-annecygenevois.fr",{"facility":199,"status":18,"city":200,"state":40,"zip":201,"country":40,"cosmosGeoPoint":202,"geoPoint":206,"contacts":207},"CHU Grenoble-Alpes","La Tronche","38700",{"type":42,"coordinates":203},[204,205],5.74629,45.20507,{"lat":205,"lon":204},[208],{"name":209,"role":31,"phone":210,"phoneExt":33,"email":211},"Christel SAINT-RAYMOND, MD","0476765522","csaint-raymond@chu-grenoble.fr",{"facility":213,"status":18,"city":214,"state":40,"zip":215,"country":40,"cosmosGeoPoint":216,"geoPoint":220,"contacts":221},"Hôpital Kremlin Bicêtre","Le Kremlin-Bicêtre","94270",{"type":42,"coordinates":217},[218,219],2.36073,48.81471,{"lat":219,"lon":218},[222],{"name":223,"role":31,"phone":224,"phoneExt":33,"email":225},"Antoine BEURNIER, MD","0145217896","antoine.beurnier@aphp.fr",{"facility":227,"status":18,"city":228,"state":40,"zip":229,"country":40,"cosmosGeoPoint":230,"geoPoint":234,"contacts":235},"CH Le Mans","Le Mans","72037",{"type":42,"coordinates":231},[232,233],0.20251,48.0021,{"lat":233,"lon":232},[236],{"name":237,"role":31,"phone":238,"phoneExt":33,"email":239},"François GOUPIL, MD","0243434345","fgoupil@ch-lemans.fr",{"facility":241,"status":18,"city":242,"state":40,"zip":243,"country":40,"cosmosGeoPoint":244,"geoPoint":248,"contacts":249},"Institut Coeur Poumon, CHU de Lille","Lille","59000",{"type":42,"coordinates":245},[246,247],3.05512,50.63391,{"lat":247,"lon":246},[250],{"name":251,"role":31,"phone":252,"phoneExt":33,"email":253},"Stéphanie FRY, MD","0320445948","stephanie.fry@chu-lille.fr",{"facility":255,"status":18,"city":256,"state":40,"zip":257,"country":40,"cosmosGeoPoint":258,"geoPoint":262,"contacts":263},"Hôpital Croix Rousse","Lyon","69004",{"type":42,"coordinates":259},[260,261],4.84789,45.74906,{"lat":261,"lon":260},[264],{"name":265,"role":31,"phone":266,"phoneExt":33,"email":267},"Gille DEVOUASSOUX, MD, PhD","0426732947","gilles.devouassoux@chu-lyon.fr",{"facility":269,"status":18,"city":270,"state":40,"zip":271,"country":40,"cosmosGeoPoint":272,"geoPoint":276,"contacts":277},"Hôpital Avicenne","Paris","75012",{"type":42,"coordinates":273},[274,275],2.3488,48.85341,{"lat":275,"lon":274},[278],{"name":279,"role":31,"phone":280,"phoneExt":33,"email":281},"Lucile SESE, MD","06677289103","Lucile.sese@aphp.fr",{"facility":283,"status":18,"city":270,"state":40,"zip":284,"country":40,"cosmosGeoPoint":285,"geoPoint":287,"contacts":288},"Hôpital Européen Georges Pompidou","75015",{"type":42,"coordinates":286},[274,275],{"lat":275,"lon":274},[289],{"name":290,"role":31,"phone":291,"phoneExt":33,"email":292},"Thibaud SOUMAGNE, MD","0156093462","thibaud.soumagne@live.fr",{"facility":294,"status":18,"city":270,"state":40,"zip":295,"country":40,"cosmosGeoPoint":296,"geoPoint":298,"contacts":299},"Hôpital Bichât","75018",{"type":42,"coordinates":297},[274,275],{"lat":275,"lon":274},[300],{"name":301,"role":31,"phone":302,"phoneExt":33,"email":303},"Camille TAILLE, MD, PhD","0140256802","camille.taille@aphp.fr",{"facility":305,"status":18,"city":306,"state":40,"zip":307,"country":40,"cosmosGeoPoint":308,"geoPoint":312,"contacts":313},"CHU de Bordeaux","Pessac","33600",{"type":42,"coordinates":309},[310,311],-0.6324,44.80565,{"lat":311,"lon":310},[314],{"name":315,"role":31,"phone":316,"phoneExt":33,"email":317},"Pierre-Olivier GIRODET, MD, PhD","0557623194","pierre-olivier.girodet@chu-bordeaux.fr",{"facility":319,"status":18,"city":320,"state":40,"zip":321,"country":40,"cosmosGeoPoint":322,"geoPoint":326,"contacts":327},"Hôpital Lyon Sud","Pierre-Bénite","69495",{"type":42,"coordinates":323},[324,325],4.82424,45.70359,{"lat":325,"lon":324},[328],{"name":329,"role":31,"phone":330,"phoneExt":33,"email":331},"Nathalie FREYMOND, MD","0478864401","nathalie.freymond@chu-lyon.fr",{"facility":333,"status":18,"city":334,"state":40,"zip":335,"country":40,"cosmosGeoPoint":336,"geoPoint":340,"contacts":341},"CHU de Guadeloupe","Pointe à Pitre","97159",{"type":42,"coordinates":337},[338,339],1.98937,44.07984,{"lat":339,"lon":338},[342],{"name":343,"role":31,"phone":344,"phoneExt":345,"email":346},"Chantal RAHERISON SEMJEN, MD, PhD","891360","+590","chantal.raherison@chu-guadeloupe.fr",{"facility":348,"status":18,"city":349,"state":40,"zip":350,"country":40,"cosmosGeoPoint":351,"geoPoint":355,"contacts":356},"CHU de Reims","Reims","51092",{"type":42,"coordinates":352},[353,354],4.02853,49.26526,{"lat":354,"lon":353},[357],{"name":358,"role":31,"phone":359,"phoneExt":33,"email":360},"Jeanne-Marie PEROTIN-COLLARD, MD, PhD","0326787614","jmperotin-collard@chu-reims.fr",{"facility":362,"status":18,"city":363,"state":40,"zip":364,"country":40,"cosmosGeoPoint":365,"geoPoint":369,"contacts":370},"CH de Roubaix","Roubaix","59100",{"type":42,"coordinates":366},[367,368],3.17456,50.69421,{"lat":368,"lon":367},[371],{"name":372,"role":31,"phone":373,"phoneExt":33,"email":374},"Nicolas JUST, MD","0320993048","nicolas.just@ch-roubaix.fr",{"facility":376,"status":18,"city":377,"state":40,"zip":378,"country":40,"cosmosGeoPoint":379,"geoPoint":383,"contacts":384},"CHU de Nantes","Saint-Herblain","44800",{"type":42,"coordinates":380},[381,382],-1.651,47.21154,{"lat":382,"lon":381},[385],{"name":386,"role":31,"phone":387,"phoneExt":33,"email":388},"François-Xavier BLANC, MD, PhD","0240165710","xavier.blanc@chu-nantes.fr",{"facility":390,"status":18,"city":391,"state":40,"zip":392,"country":40,"cosmosGeoPoint":393,"geoPoint":397,"contacts":398},"Nouvel Hôpital Civil","Strasbourg","67000",{"type":42,"coordinates":394},[395,396],7.74553,48.58392,{"lat":396,"lon":395},[399],{"name":400,"role":31,"phone":401,"phoneExt":33,"email":402},"Naji KHAYATH, MD","0369550898","naji.khayath@chru-strasbourg.fr",{"facility":404,"status":18,"city":405,"state":40,"zip":406,"country":40,"cosmosGeoPoint":407,"geoPoint":411,"contacts":412},"Hôpital Foch","Suresnes","92150",{"type":42,"coordinates":408},[409,410],2.22929,48.87143,{"lat":410,"lon":409},[413],{"name":414,"role":31,"phone":415,"phoneExt":33,"email":416},"Colas TCHERAKIAN, MD, PhD","0146252315","c.tcherakian@hopital-foch.com",{"facility":418,"status":18,"city":419,"state":40,"zip":420,"country":40,"cosmosGeoPoint":421,"geoPoint":425,"contacts":426},"Hôpital Tarbes Lourdes","Tarbes","65000",{"type":42,"coordinates":422},[423,424],0.07139,43.23407,{"lat":424,"lon":423},[427],{"name":428,"role":31,"phone":429,"phoneExt":33,"email":430},"Joëlle COURDEAU, MD","0562546060","jcourdeau-labourie@ch-tarbes.vic.fr",{"type":432,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100578955",false,"NCT06818019","Withdrawal of Dupilumab in Severe Asthma","WIthdrawal of DUpilumab in Severe Asthma: a Randomized Non-inferiority-controlled Trial","WIDUSA","Inclusion Criteria:\n\n* Adult patients ≥ 18 years old\n* Treated with dupilumab for at least 36 months for severe asthma\n* Well controlled asthma defined by an Asthma Control Questionnaire score ≥ 18 and 0 or 1 exacerbation within the year prior to the inclusion visit\n\nExclusion Criteria:\n\n* Patients who refuse to discontinue dupilumab, for any reason\n* Patients with Forced expiratory volume in one second ≤ 30% of predicted values\n* Patients treated by an oral corticosteroid dose ≥ 10 mg\u002Fday (in prednisone equivalent)\n* Patients who have to discontinue dupilumab for a reason other than controlled asthma, such as an adverse drug reaction, a planned or current pregnancy, or a planned switch to another biologic indicated in severe asthma\n* Patients who have to continue dupilumab for the treatment of comorbidities apart from nasal polyposis\n* Active smoking\n* Pregnancy or breastfeeding","ALL","18 Years",{"count":443,"type":444},205,"ESTIMATED","INTERVENTIONAL",[447],"PHASE4","Asthma management has been revolutionised by the development of biological therapies. Dupilumab is an anti-interleukin4 receptor marketed in 2020 for severe asthmatic patients with 2 exacerbations or more within the last 12 months. Although data showed that safety and efficacy of dupilumab are sustained when treatment is extended up to 3 years, no study has emerged regarding dupilumab discontinuation. This study aims to demonstrate the non-inferiority regarding strategy failure at 24 months of stopping dupilumab (intervention group) compared with its continuation (control group) in controlled asthma patients receiving this drug for at least 3 years.",[450],"Severe Asthma",[452,453,454,455],"severe asthma","dupilumab","exacerbation","discontinuation","NOT_YET_RECRUITING","2025-02-07",{"date":459,"type":460},"2025-02-10","ACTUAL",{"date":462,"type":444},"2025-04-02",{"date":464,"type":444},"2029-12-31",{"name":5,"class":6},29]