[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100361063":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":35,"centralContacts":40,"locations":50,"responsibleParty":293,"collaborators":297,"id":303,"slug":10,"hasResults":304,"nctId":305,"briefTitle":306,"officialTitle":306,"acronym":307,"eligibilityCriteria":308,"healthyVolunteers":309,"sex":310,"minAge":10,"maxAge":10,"enrollmentInfo":311,"targetDuration":314,"studyType":315,"phases":10,"briefSummary":316,"conditions":317,"keywords":319,"overallStatus":53,"whyStopped":10,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":331,"locationsCount":332},{"fullName":5,"class":6},"University Hospital Tuebingen","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Primary participant:",null,"Participants affected by hereditary spastic paraplegia (HSP) or a phenotypically related disorder Primary participants will be followed at annual intervals. The workup includes clinical, imaging, sensor-based, patient\u002Fobserver reported and molecular outcome parameters and biosampling.\n\nParticipants with unknown genetic diagnosis may receive genetic testing including whole exome or whole genome sequencing and other OMICS techniques.",[13,14],"Other: Clinical rating scale to measure disease severity and progression","Diagnostic Test: Next-Gen Sequencing (NGS)",{"label":16,"type":10,"description":17,"interventionNames":18},"Secondary participant\u002F First or second-degree","First or second degree unaffected family members of primary participants. Secondary participants may undergo the same study procedures as primary participants.",[14],{"label":20,"type":10,"description":21,"interventionNames":22},"Unrelated healthy control","Unrelated healthy controls Healthy controls may undergo the same study procedures as primary participants.",[14],[24,30],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"Clinical rating scale to measure disease severity and progression","A 13-item scale to rate functional impairment occurring in pure forms of spastic paraplegia (SP). Additional symptoms constituting a complicated form of SP are recorded in an inventory.",[9],[29],"Spastic Paraplegia Rating Scale (SPRS)",{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"DIAGNOSTIC_TEST","Next-Gen Sequencing (NGS)","Whole Genome Sequencing, Whole Exome Sequencing, Transcriptomics, Proteomics, Metabolomics",[9,16,20],[36],{"name":37,"affiliation":38,"role":39},"Rebecca Schüle, PD Dr.","University Hospital Tübingen","PRINCIPAL_INVESTIGATOR",[41,46],{"name":37,"role":42,"phone":43,"phoneExt":44,"email":45},"CONTACT","+49 7071 29","85653","rebecca.schuele-freyer@uni-tuebingen.de",{"name":47,"role":42,"phone":43,"phoneExt":48,"email":49},"Ludger Schöls, Prof. Dr.","85548","ludger.schoels@uni-tuebingen.de",[51,76,95,116,132,154,171,187,205,223,239,255,277],{"facility":52,"status":53,"city":54,"state":10,"zip":55,"country":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"University Innsbruck","RECRUITING","Innsbruck","6020","Austria",{"type":58,"coordinates":59},"Point",[60,61],11.39454,47.26266,{"lat":61,"lon":60},[64,68,71,73],{"name":65,"role":42,"phone":66,"phoneExt":10,"email":67},"Matthias Amprosi","+43 512 504 83686","matthias.amprosi@i-med.ac.at",{"name":69,"role":42,"phone":66,"phoneExt":10,"email":70},"Sylvia Bösch","sylvia.boesch@i-med.ac.at",{"name":72,"role":39,"phone":10,"phoneExt":10,"email":10},"Sylvia Bösch, MD",{"name":74,"role":75,"phone":10,"phoneExt":10,"email":10},"Matthias Amprosi, MD","SUB_INVESTIGATOR",{"facility":77,"status":53,"city":78,"state":10,"zip":79,"country":80,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"German Center for Neurodegenerative Diseases (DZNE) Bonn","Bonn","53127","Germany",{"type":58,"coordinates":82},[83,84],7.09549,50.73438,{"lat":84,"lon":83},[87,91,93],{"name":88,"role":42,"phone":89,"phoneExt":10,"email":90},"Thomas Klockgether","+49 228 28715726","Thomas.Klockgether@dzne.de",{"name":92,"role":39,"phone":10,"phoneExt":10,"email":10},"Thomas Klockgether, MD",{"name":94,"role":75,"phone":10,"phoneExt":10,"email":10},"Xenia Kobeleva, MD",{"facility":96,"status":53,"city":97,"state":10,"zip":98,"country":80,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"University of Erlangen","Erlangen","91054",{"type":58,"coordinates":100},[101,102],11.00783,49.59099,{"lat":102,"lon":101},[105,109,112,114],{"name":106,"role":42,"phone":107,"phoneExt":10,"email":108},"Susanne Seifert","+49 9131 85 44751","susanne.seifert@uk-erlangen.de",{"name":110,"role":42,"phone":107,"phoneExt":10,"email":111},"Pia-Marie Pryssok","pia-marie.pryssok@uk-erlangen.de",{"name":113,"role":39,"phone":10,"phoneExt":10,"email":10},"Jürgen Winkler, MD",{"name":115,"role":75,"phone":10,"phoneExt":10,"email":10},"Heiko Gassner, Dr. Phil.",{"facility":117,"status":53,"city":118,"state":10,"zip":119,"country":80,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"University Medicine Essen","Essen","45147",{"type":58,"coordinates":121},[122,123],7.01228,51.45657,{"lat":123,"lon":122},[126,130],{"name":127,"role":42,"phone":128,"phoneExt":10,"email":129},"Sylwia Kante","+49 201 - 7236513","sylwia.kante@uk-essen.de",{"name":131,"role":39,"phone":10,"phoneExt":10,"email":10},"Stephan Klebe, MD",{"facility":133,"status":53,"city":134,"state":10,"zip":135,"country":80,"cosmosGeoPoint":136,"geoPoint":140,"contacts":141},"University Göttingen","Göttingen","37075",{"type":58,"coordinates":137},[138,139],9.93228,51.53443,{"lat":139,"lon":138},[142,146,148,150,152],{"name":143,"role":42,"phone":144,"phoneExt":10,"email":145},"Anja Schadenberg","+49 551 39 10206","aschadenberg@med.uni-goettingen.de",{"name":147,"role":39,"phone":10,"phoneExt":10,"email":10},"Michael Sereda, MD",{"name":149,"role":75,"phone":10,"phoneExt":10,"email":10},"Sonja Fritzsch, MD",{"name":151,"role":75,"phone":10,"phoneExt":10,"email":10},"Knut Brockmann, MD",{"name":153,"role":39,"phone":10,"phoneExt":10,"email":10},"Anne van Riesen, MD",{"facility":155,"status":156,"city":157,"state":10,"zip":158,"country":80,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"University Heidelberg","NOT_YET_RECRUITING","Heidelberg","69120",{"type":58,"coordinates":160},[161,162],8.69079,49.40768,{"lat":162,"lon":161},[165,169],{"name":166,"role":42,"phone":167,"phoneExt":10,"email":168},"Heike Jacobi","+49 6221 - 56 - 7510","Heike.Jacobi@med.uni-heidelberg.de",{"name":170,"role":39,"phone":10,"phoneExt":10,"email":10},"Heike Jacobi, MD",{"facility":172,"status":156,"city":173,"state":10,"zip":174,"country":80,"cosmosGeoPoint":175,"geoPoint":179,"contacts":180},"University of Lübeck","Lübeck","23562",{"type":58,"coordinates":176},[177,178],10.68729,53.86893,{"lat":178,"lon":177},[181,185],{"name":182,"role":42,"phone":183,"phoneExt":10,"email":184},"Maike Dümcke-Zilian","+49 451 3101 8215","maike.duemcke-zilian@neuro.uni-luebeck.de",{"name":186,"role":39,"phone":10,"phoneExt":10,"email":10},"Alexander Münchau, MD",{"facility":188,"status":53,"city":189,"state":10,"zip":190,"country":80,"cosmosGeoPoint":191,"geoPoint":195,"contacts":196},"German Center for Neurogedenerative Diseases (DZNE) Magdeburg","Magdeburg","39120",{"type":58,"coordinates":192},[193,194],11.63189,52.13129,{"lat":194,"lon":193},[197,201,203],{"name":198,"role":42,"phone":199,"phoneExt":10,"email":200},"Michaela Butryn","+49 391-67-13431","michaela.butryn@med.ovgu.de",{"name":202,"role":39,"phone":10,"phoneExt":10,"email":10},"Stefan Vielhaber, MD",{"name":204,"role":75,"phone":10,"phoneExt":10,"email":10},"Michaela Butryn, MD",{"facility":206,"status":53,"city":207,"state":10,"zip":208,"country":80,"cosmosGeoPoint":209,"geoPoint":213,"contacts":214},"German Center for Neurodegenerative Diseases (DZNE) München","München","80336",{"type":58,"coordinates":210},[211,212],13.31243,51.60698,{"lat":212,"lon":211},[215,219,221],{"name":216,"role":42,"phone":217,"phoneExt":10,"email":218},"Jasmina Al-Tamami","+49 89 4400 57425","jasmina.altamami@med.uni-muenchen.de",{"name":220,"role":39,"phone":10,"phoneExt":10,"email":10},"Thomas Klopstock, MD",{"name":222,"role":75,"phone":10,"phoneExt":10,"email":10},"Florentine Radelfahrt, MD",{"facility":224,"status":156,"city":225,"state":10,"zip":226,"country":80,"cosmosGeoPoint":227,"geoPoint":231,"contacts":232},"University of Regensburg","Regensburg","93053",{"type":58,"coordinates":228},[229,230],12.10161,49.01513,{"lat":230,"lon":229},[233,237],{"name":234,"role":42,"phone":235,"phoneExt":10,"email":236},"Zacharias Kohl","+49 941 941 3074","zacharias.kohl@ukr.de",{"name":238,"role":39,"phone":10,"phoneExt":10,"email":10},"Zacharias Kohl, MD",{"facility":240,"status":156,"city":241,"state":10,"zip":242,"country":80,"cosmosGeoPoint":243,"geoPoint":247,"contacts":248},"German Center for Neurodegenerative Diseases (DZNE) Rostock","Rostock","18147",{"type":58,"coordinates":244},[245,246],12.14049,54.0887,{"lat":246,"lon":245},[249,253],{"name":250,"role":42,"phone":251,"phoneExt":10,"email":252},"Christoph Kamm","+49 381 4944763","christoph.kamm@med.uni-rostock.de",{"name":254,"role":39,"phone":10,"phoneExt":10,"email":10},"Christoph Kamm, MD",{"facility":256,"status":53,"city":257,"state":10,"zip":258,"country":80,"cosmosGeoPoint":259,"geoPoint":263,"contacts":264},"University of Tübingen and German Center for Neurodegenerative Diseases (DZNE) Tübingen","Tübingen","72076",{"type":58,"coordinates":260},[261,262],9.05222,48.52266,{"lat":262,"lon":261},[265,269,271,273,275],{"name":266,"role":42,"phone":267,"phoneExt":10,"email":268},"Katrin Dillmann","+49 7071 29 85653","katrin.dillmann@med.uni-tuebingen.de",{"name":270,"role":39,"phone":10,"phoneExt":10,"email":10},"Rebecca Schüle, MD",{"name":272,"role":75,"phone":10,"phoneExt":10,"email":10},"Ludger Schöls, MD",{"name":274,"role":75,"phone":10,"phoneExt":10,"email":10},"Ingeborg Krägeloh-Mann, MD",{"name":276,"role":75,"phone":10,"phoneExt":10,"email":10},"Marion Döbler-Neumann, MD",{"facility":278,"status":156,"city":279,"state":10,"zip":280,"country":281,"cosmosGeoPoint":282,"geoPoint":286,"contacts":287},"IRCCS Medea Scientific Institute, Conegliano-PIeve di Soligo Research Centre","Pieve di Soligo","31053","Italy",{"type":58,"coordinates":283},[284,285],12.17128,45.89836,{"lat":285,"lon":284},[288,292],{"name":289,"role":42,"phone":290,"phoneExt":10,"email":291},"Andrea Martinuzzi, MD","0438 414337","andrea.martinuzzi@lanostrafamiglia.it",{"name":289,"role":39,"phone":10,"phoneExt":10,"email":10},{"type":294,"investigatorFullName":295,"investigatorTitle":296,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Dr. Rebecca Schule","Principal Investigator, Leading Consultant",[298,301],{"name":299,"class":300},"German Federal Ministry of Education and Research","OTHER_GOV",{"name":302,"class":6},"German Center for Neurodegenerative Diseases (DZNE)","100361063",false,"NCT03981276","Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders","HSP-PBP","Inclusion criteria:\n\n* One of the following:\n\n  1. Primary participant: Clinical or genetic diagnosis of HSP or a related disorder\n  2. Secondary participant: Unaffected family member (1st or 2nd degree relative) of primary participant (with the above-mentioned restrictions for special populations) able to give informed consent\n  3. Unrelated healthy control able to give informed consent\n\n     AND\n* Written informed consent\n\nAND\n\n\\- Participants are willing and able to comply with study procedures\n\nExclusion criteria:\n\n* Missing informed consent of primary or secondary participant\u002F healthy control\u002F legal representatives\n* For controls: evidence of a neurodegenerative disease or movement disorders; inability to give informed consent",true,"ALL",{"count":312,"type":313},2000,"ESTIMATED","20 Years","OBSERVATIONAL","The aim of this study is to determine the clinical spectrum and natural progression of Hereditary Spastic Paraplegias (HSP) and related disorders in a prospective multicenter natural history study, identify digital, imaging and molecular biomarkers that can assist in diagnosis and therapy development and study the genetic etiology and molecular mechanisms of these diseases.",[318],"Hereditary Spastic Paraplegia",[318,320,321,322],"Biomarker","Genetic etiology","Molecular mechanisms","2021-05-18",{"date":325,"type":326},"2021-05-19","ACTUAL",{"date":328,"type":326},"2019-10-14",{"date":330,"type":313},"2041-08",{"name":295,"class":6},13]