[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604575":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":30,"responsibleParty":42,"collaborators":25,"id":46,"slug":25,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":47,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":25,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":67,"whyStopped":25,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Sinai University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Bee Venom Phonophoresis","EXPERIMENTAL","Participants receive bee venom phonophoresis therapy applied to the affected knee(s) using standardized ultrasound parameters. Bee venom topical preparation will be mixed with ultrasound coupling gel and applied to the treatment area. Ultrasound will be delivered at a standardized frequency, intensity, and duration determined before study commencement.",[13,14],"Device: Ultrasound therapy unit","Biological: Bee venom topical preparation (for phonophoresis)",{"label":16,"type":17,"description":18,"interventionNames":19},"Control - Placebo Phonophoresis","PLACEBO_COMPARATOR","Participants receive placebo phonophoresis using the same ultrasound parameters as the experimental group, but with a neutral coupling gel that does not contain bee venom. This ensures the same patient experience without the active bee venom component.",[13],[21,26],{"type":22,"name":23,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Ultrasound therapy unit",[9,16],null,{"type":27,"name":28,"description":28,"armGroupLabels":29,"otherNames":25},"BIOLOGICAL","Bee venom topical preparation (for phonophoresis)",[9],[31],{"facility":32,"status":25,"city":33,"state":25,"zip":34,"country":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":25},"Sinai university","Cairo","44511","Egypt",{"type":37,"coordinates":38},"Point",[39,40],31.24967,30.06263,{"lat":40,"lon":39},{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Amany Gomaa Atiaa","lecturer","100604575",false,"NCT07151300","Phonophoresis With Bee Venom: Evaluating Its Efficacy in Managing Pain and Enhancing Mobility in Knee Osteoarthritis Patients","BEE-KNEE","Inclusion Criteria:\n\n* Age 40-75 years\n* Clinically and radiographically confirmed knee osteoarthritis\n* Moderate to severe pain (VAS ≥ 4)\n* Willingness to provide informed consent\n\nExclusion Criteria:\n\n* Allergy to bee products or topical agents used in the study\n* Knee surgery or trauma in the past year\n* Intra-articular injection in the past 6 months\n* Other musculoskeletal or systemic conditions affecting the knees (e.g., rheumatoid arthritis)\n* Pregnancy or contraindication to ultrasound therapy","ALL","40 Years","75 Years",{"count":56,"type":57},30,"ESTIMATED","INTERVENTIONAL",[60],"NA","Brief Summary:\n\nThis single-blind, randomized controlled trial will investigate the efficacy of bee venom phonophoresis in managing pain and improving mobility in patients with knee osteoarthritis. Thirty adults aged 40-75 years with clinically and radiographically confirmed knee osteoarthritis will be randomly assigned to receive either bee venom phonophoresis or placebo phonophoresis with a neutral gel. Ultrasound parameters will be standardized for all participants.\n\nPrimary outcomes are pain reduction, measured by the Visual Analog Scale (VAS), and functional mobility, assessed by the Timed Up and Go (TUG) test. The secondary outcome is walking endurance, measured by the Six-Minute Walk Test (6MWT). Assessments will be conducted at baseline and post-intervention.\n\nThe study is designed to determine whether bee venom phonophoresis offers greater clinical benefit compared to placebo phonophoresis, potentially providing a non-invasive, adjunctive treatment option for knee osteoarthritis. Ethical approval has been obtained from the Faculty of Physical Therapy, Sinai University, and all participants will provide written informed consent.",[63,64],"Knee Osteoarthritis","Osteoarthritis",[64,66],"Osteoarthritis, Knee","NOT_YET_RECRUITING","2026-05-05",{"date":70,"type":71},"2026-05-11","ACTUAL",{"date":73,"type":57},"2026-05-15",{"date":75,"type":57},"2026-12-25",{"name":5,"class":6},1]