About this trial

This randomized, double-blind clinical trial aims to evaluate the impact of photobiomodulation therapy on postoperative outcomes in patients undergoing coronary artery bypass grafting (CABG). The study will compare two techniques for saphenous vein graft harvesting: the conventional technique and the no-touch technique. Participants will be randomly allocated into four groups: conventional harvesting with placebo, conventional harvesting with photobiomodulation, no-touch harvesting with placebo, and no-touch harvesting with photobiomodulation. The primary objective is to evaluate the effects of photobiomodulation on wound healing and postoperative complications related to the saphenous vein harvesting site. Secondary outcomes include clinical outcomes and functional capacity after surgery. The results may contribute to improving postoperative recovery and optimizing surgical strategies in patients undergoing myocardial revascularization.

Eligibility criteria

Qualifiers

Patients diagnosed with coronary artery disease scheduled to undergo elective coronary artery bypass grafting (CABG)

Use of the saphenous vein as a graft for myocardial revascularization

Ability to understand the study procedures and provide written informed consent

Disqualifiers

Emergency coronary artery bypass surgery

Previous surgery in the lower limb that prevents saphenous vein harvesting

Active infection at the surgical site or lower limb

Severe peripheral arterial disease in the lower limbs

Trial design

Treatments tested in this trial

  • Photobiomodulation Therapy
  • Placebo Laser
  • Conventional Saphenous Vein Harvesting
  • No-Touch Saphenous Vein Harvesting

Treatment groups

292 Participants
are divided into 4 treatment groups

Locations

1
Hospital São Paulo, Federal University of São Paulo04021001, São PauloSão Paulo, Brazil

Sponsors and collaborators

Federal University of São Paulo

Lead sponsor