[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100054302":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":36,"centralContacts":50,"locations":56,"responsibleParty":68,"collaborators":36,"id":72,"slug":36,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":73,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":36,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":100,"whyStopped":36,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Federal University of São Paulo","OTHER",[8,15,21,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Conventional Harvesting + Placebo","PLACEBO_COMPARATOR","Patients undergoing conventional saphenous vein harvesting with simulated laser application (placebo).",[13,14],"Device: Placebo Laser","Procedure: Conventional Saphenous Vein Harvesting",{"label":16,"type":17,"description":18,"interventionNames":19},"Conventional Harvesting + Photobiomodulation","EXPERIMENTAL","Patients undergoing conventional saphenous vein harvesting with active photobiomodulation therapy applied to the surgical incision.",[20,14],"Device: Photobiomodulation Therapy",{"label":22,"type":10,"description":23,"interventionNames":24},"No-touch Harvesting + Placebo","Patients undergoing saphenous vein harvesting using the no-touch technique with simulated laser application.",[13,25],"Procedure: No-Touch Saphenous Vein Harvesting",{"label":27,"type":17,"description":28,"interventionNames":29},"No-touch Harvesting + Photobiomodulation","Patients undergoing saphenous vein harvesting using the no-touch technique with active photobiomodulation therapy applied to the surgical incision.",[20,25],[31,37,41,46],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DEVICE","Photobiomodulation Therapy","Photobiomodulation will be applied using a cluster laser device (E-light, DMC Equipamentos Ltda., Brazil) with wavelength of 660 nm and output power of 100 mW. The therapy will be applied along the surgical incision of the saphenous vein harvesting site using a point technique with standardized spacing between application points. The intervention will be performed intraoperatively and during the early postoperative period.",[16,27],null,{"type":32,"name":38,"description":39,"armGroupLabels":40,"otherNames":36},"Placebo Laser","Simulated photobiomodulation therapy applied using the same laser device without emission of therapeutic laser energy. This placebo procedure is used to maintain blinding of participants and outcome assessors.",[9,22],{"type":42,"name":43,"description":44,"armGroupLabels":45,"otherNames":36},"PROCEDURE","Conventional Saphenous Vein Harvesting","Conventional Saphenous Vein Harvesting refers to the traditional open surgical technique used to obtain the great saphenous vein for grafting procedures, most commonly in coronary artery bypass grafting (CABG). The procedure involves a continuous longitudinal incision along the course of the vein in the lower limb, allowing direct visualization and careful dissection of the vessel from surrounding tissues. Side branches are ligated or clipped, and the harvested vein is subsequently prepared for use as a vascular graft. The technique is performed under sterile surgical conditions by qualified surgeons.",[16,9],{"type":42,"name":47,"description":48,"armGroupLabels":49,"otherNames":36},"No-Touch Saphenous Vein Harvesting","No-Touch Saphenous Vein Harvesting refers to a surgical technique for harvesting the great saphenous vein in which the vein is removed together with a pedicle of surrounding perivascular tissue, avoiding direct manual manipulation and excessive distension of the vessel. The procedure is performed through an open incision under sterile conditions, preserving the vein's adventitia, vasa vasorum, and surrounding connective tissue in order to minimize endothelial injury and maintain vascular integrity. Side branches are carefully ligated or clipped, and the harvested graft is prepared according to institutional surgical protocols for subsequent use in vascular or coronary artery bypass procedures.",[27,22],[51],{"name":52,"role":53,"phone":54,"phoneExt":36,"email":55},"Solange Guizilini, PhD","CONTACT","+55 11 982887753","sguizilini@unifesp.br",[57],{"facility":58,"status":36,"city":59,"state":59,"zip":60,"country":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":36},"Hospital São Paulo, Federal University of São Paulo","São Paulo","04021001","Brazil",{"type":63,"coordinates":64},"Point",[65,66],-46.63611,-23.5475,{"lat":66,"lon":65},{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"PRINCIPAL_INVESTIGATOR","Solange Guizilini","Principal Investigator","100054302",false,"NCT07699679","Photobiomodulation in Coronary Artery Bypass Grafting With No-Touch vs Conventional Saphenous Vein Harvesting.","Impact of Photobiomodulation in Coronary Artery Bypass Surgery: Comparison Between No-Touch and Conventional Saphenous Vein Harvesting Techniques on Clinical Outcomes, Functional Capacity, and Wound Healing: A Randomized Clinical Trial","PHOTON","Inclusion Criteria:\n\n* Patients diagnosed with coronary artery disease scheduled to undergo elective coronary artery bypass grafting (CABG)\n* Use of the saphenous vein as a graft for myocardial revascularization\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Emergency coronary artery bypass surgery\n* Previous surgery in the lower limb that prevents saphenous vein harvesting\n* Active infection at the surgical site or lower limb\n* Severe peripheral arterial disease in the lower limbs\n* Hemodynamic instability preventing study protocol procedures\n* Participation in another interventional clinical trial that may interfere with the outcomes of this study\n* Patients unable to perform postoperative functional capacity assessments\n* Individuals with highly pigmented skin or sensibility that may alter light absorption and penetration of the photobiomodulation therapy.","ALL","18 Years","75 Years",{"count":83,"type":84},292,"ESTIMATED","INTERVENTIONAL",[87],"NA","This randomized, double-blind clinical trial aims to evaluate the impact of photobiomodulation therapy on postoperative outcomes in patients undergoing coronary artery bypass grafting (CABG). The study will compare two techniques for saphenous vein graft harvesting: the conventional technique and the no-touch technique. Participants will be randomly allocated into four groups: conventional harvesting with placebo, conventional harvesting with photobiomodulation, no-touch harvesting with placebo, and no-touch harvesting with photobiomodulation. The primary objective is to evaluate the effects of photobiomodulation on wound healing and postoperative complications related to the saphenous vein harvesting site. Secondary outcomes include clinical outcomes and functional capacity after surgery. The results may contribute to improving postoperative recovery and optimizing surgical strategies in patients undergoing myocardial revascularization.",[90,91,92],"Coronary Artery Disease","Coronary Artery Bypass Graft (CABG)","Surgical Wound Healing",[94,95,96,97,98,99],"Photobiomodulation","Low-Level Laser Therapy","Coronary Artery Bypass Grafting","Saphenous Vein Harvesting","No-Touch Technique","Wound Healing","NOT_YET_RECRUITING","2026-07-08",{"date":103,"type":104},"2026-07-13","ACTUAL",{"date":106,"type":84},"2026-08",{"date":108,"type":84},"2028-03",{"name":5,"class":6},1]