[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591697":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":10,"centralContacts":35,"locations":44,"responsibleParty":56,"collaborators":10,"id":58,"slug":10,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":10,"enrollmentInfo":66,"targetDuration":69,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":76,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"National University Hospital, Singapore","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients diagnosed with patient foramen ovale and ischemic stroke or transient ischemic attack.",null,"The PACIFIC-PFO registry aims to include patients from Asia and Oceania. Academic, non-academic, urban and rural sites will be included. Principal investigators will be neurologists or cardiologists. A confirmed diagnosis of ischemic stroke or TIA is mandatory before enrolment. Information on the interventions performed and treatment instigated (e.g. PFO closure, medical therapy) will be collected.",[13,14],"Procedure: PFO closure using approved PFO closure devices, Surgical PFO closure","Drug: Medical management",[16,27],{"type":17,"name":18,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","PFO closure using approved PFO closure devices, Surgical PFO closure",[9],[21,22,23,24,25,26],"Amplatzer™ Septal Occluder","Amplatzer™ PFO Occluder","Amplatzer™ Cribriform (for a septum with more than one hole)","Gore® Cardioform Septal Occluder","Gore® Cardioform ASD Occluder (for larger ASDs)","STARFlex® Septal Closure System",{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DRUG","Medical management","Antiplatelet therapy\n\n* ASA, also called acetylsalicylic acid (Aspirin, Asaphen, Entrophen, Novasen)\n* clopidogrel (Plavix)\n* ticagrelor (Brilinta)\n* dipyridamole (Persantine)\n* cilostazol\n\nAnticoagulation therapy\n\n* apixaban (Eliquis)\n* dabigatran (Pradaxa)\n* edoxaban (Lixiana)\n* rivaroxaban (Xarelto)\n* warfarin (Coumadin)",[9],[33,34],"Antiplatelet therapy e.g. aspirin, clopidogrel, ticagrelor, dipyridamole, cilostazol, or a combination of these medications","Anticoagulation e.g warfarin, direct oral anticoagulants",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},"Benjamin Y Tan, MBBS","CONTACT","+65 6779 5555","benjamin_yq_tan@nuhs.edu.sg",{"name":42,"role":38,"phone":39,"phoneExt":10,"email":43},"Ching-Hui Sia, MBBS","ching_hui_sia@nuhs.edu.sg",[45],{"facility":46,"status":10,"city":47,"state":10,"zip":10,"country":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"National University Hospital","Singapore",{"type":49,"coordinates":50},"Point",[51,52],103.85007,1.28967,{"lat":52,"lon":51},[55],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},{"type":57,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100591697",false,"NCT06983795","Pioneering Advancements in Cardiocerebrovascular Interactions in the Asia pacFIC - Patent Foramen Ovale Study","PACIFIC-PFO","Inclusion Criteria\n\n1. Subject has experienced acute ischemic stroke or transient ischemic attack\n2. Subject is screened with presence of PFO (right-to-left shunt) on appropriate cardiac imaging (transthoracic echocardiography and\u002For transesophageal echocardiography) or transcranial Doppler bubble study\n3. Age ≥18 years\n\nExclusion Criteria\n\n1. Stroke mimics, haemorrhagic stroke or cerebral venous thrombosis\n2. Subjects with less than 3 months of follow up","ALL","18 Years",{"count":67,"type":68},1000,"ESTIMATED","5 Years","OBSERVATIONAL","A registry of patients from the Asia-Pacific region with PFO and ischemic stroke, designed to study the characteristics, investigations, treatment and outcomes using real-world data.",[73,74],"Ischemic Stroke","Patent Foramen Ovale",[74,73],"NOT_YET_RECRUITING","2025-05-14",{"date":79,"type":80},"2025-05-21","ACTUAL",{"date":82,"type":68},"2025-07",{"date":84,"type":68},"2030-12",{"name":5,"class":6},1]