[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581093":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":38,"responsibleParty":52,"collaborators":56,"id":59,"slug":12,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":12,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":41,"whyStopped":12,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"KU Leuven","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Usual care","NO_INTERVENTION","care as usual: central laboratory troponine testing",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Intervention","ACTIVE_COMPARATOR","To establish in a randomized interventional controlled trial whether a novel POC test-guided strategy in acute chest pain patients in the ED results in a reduced length of stay compared to the usual central laboratory testing strategy when managing patients with a suspicion of NSTEMI",[18],"Device: Point-of-Care high-sensitivity troponin testing",[20],{"type":21,"name":22,"description":16,"armGroupLabels":23,"otherNames":12},"DEVICE","Point-of-Care high-sensitivity troponin testing",[14],[25],{"name":26,"affiliation":27,"role":28},"Jan YJ Verbakel, MD, PhD, Professor","Leuven Unit for Health Technology Assessment Research, University of Leuven","STUDY_DIRECTOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":12,"email":34},"Tine De Burghgraeve, PhD","CONTACT","+3216377276","tine.deburghgraeve@kuleuven.be",{"name":36,"role":32,"phone":12,"phoneExt":12,"email":37},"David Bos, PhD student, MD","david.bos@kuleuven.be",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":12},"KU\u002F UZ Leuven ED","RECRUITING","Leuven","Vlaams-Brabant","3000","Belgium",{"type":47,"coordinates":48},"Point",[49,50],4.70093,50.87959,{"lat":50,"lon":49},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"PRINCIPAL_INVESTIGATOR","Jan Verbakel","Professor",[57],{"name":58,"class":6},"Universitaire Ziekenhuizen KU Leuven","100581093",false,"NCT06845826","Point-of-Care Troponin Testing in the Emergency Department","Point-of-Care High-Sensitivity Troponin Testing in the Emergency Department to Assess Myocardial Infarction for Timely Discharge","CERMIT","Inclusion Criteria:\n\n* Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures - At least 18 years of age at the time of signing the Informed Consent Form (ICF)\n* Age \\\u003C 75 years of age\n* Presenting with chest pain or chest pain-equivalent symptom suspect of acute coronary syndrome at the University Hospitals Leuven emergency department; Symptoms must have (had) a minimum duration of 15 minutes, and the current, ongoing episode of symptoms must have started within the past 12 hours.\n\nExclusion Criteria:\n\n* Unable to provide written informed consent\n* Age \\\u003C18 years or \\>75 years\n* Chest pain or equivalent symptom with a duration shorter than 15 minutes, or an onset of the current, ongoing episode of symptoms more than 12 hours ago\n* Clinically unstable patients or confirmed STEMI patients, requiring immediate treatment\n* Patients with recent chest trauma\n* Patients transferred from another hospital\n* Any disorder, which in the investigator's opinion might jeopardise participant's safety or compliance with the CISP.","ALL","18 Years","75 Years",{"count":70,"type":71},1552,"ESTIMATED","INTERVENTIONAL",[74],"NA","The goal of this study is to evaluate whether a POC-guided testing strategy to exclude non-ST elevation myocardial infarction (NSTEMI) in acute chest pain patients presenting at the emergency department (ED) can result in a shorter length of stay compared to the routine central laboratory testing strategy. Currently, most often two high-sensitivity troponin (hs-cTn) tests are required for exclusion of NSTEMI, and central laboratories are struggling to achieve the recommended turnaround time of 60 minutes. Novel POC hs-cTn testing technology can provide results in minutes, potentially reducing the ED length of stay. This may lead to a reduction in ED crowding, which is a growing worldwide healthcare problem, resulting in poorer patient outcomes. This study may therefore improve patient burden, ED staff workload, and lead to more efficient expenditure of healthcare resources.\n\nWe will perform a prospective, cross-sectional, interventional, single-center, open label, randomized trial.\n\nAll consecutive patients older than 18 years and younger than 75 years presenting at the UZ Leuven emergency department with chest pain or chest pain-equivalent symptoms suspected of an acute coronary syndrome (ACS) will be invited to participate in the study. After informed consent patients will be randomized into the point-of-care testing (POCT) group or the usual care group. Patients in the POCT group will undergo the novel POC test-guided strategy. In the POC strategy the first hs-cTnI test shortly after admission to the ED will be performed on the POC Atellica VTLi. The second test will be performed with the usual central laboratory hs-cTnT test. Patients in the usual care group will undergo the usual testing strategy with one or two hs-cTnT tests performed in the hospital's central laboratory.",[77],"Acute Coronary Syndromes",[79,80,81],"POCT","troponine testing","acute coronary syndrome","2026-03-16",{"date":84,"type":85},"2026-03-18","ACTUAL",{"date":87,"type":85},"2025-06-30",{"date":89,"type":71},"2026-12-30",{"name":5,"class":6},1]