[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577563":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":28,"responsibleParty":54,"collaborators":56,"id":64,"slug":20,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":20,"enrollmentInfo":73,"targetDuration":20,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":86,"overallStatus":31,"whyStopped":20,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Centre Hospitalier Universitaire, Amiens","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Parkinson's disease","EXPERIMENTAL","Patients 18 years age or older with Parkinson's disease or essential tremor and tremor resistant to medical therapy with a contraindication to deep brain stimulation or refusal deep brain stimulation",[13],"Procedure: laser electrode",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","laser electrode","A laser electrode is implanted surgically in the ventral and inteermediary nucleus of the thalamus (VIM).",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":26,"email":27},"Michel LEFRANC, Pr","CONTACT","0322088950","33","lefranc.michel@chu-amiens.fr",[29],{"facility":30,"status":31,"city":32,"state":20,"zip":33,"country":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"CHRU Amiens","RECRUITING","Salouël","80480","France",{"type":36,"coordinates":37},"Point",[38,39],2.2434,49.86988,{"lat":39,"lon":38},[42,44,47,50,52],{"name":43,"role":24,"phone":25,"phoneExt":26,"email":27},"Michel Lefranc, Pr",{"name":45,"role":46,"phone":20,"phoneExt":20,"email":20},"Melissa Tir, MD","SUB_INVESTIGATOR",{"name":48,"role":49,"phone":20,"phoneExt":20,"email":20},"David MALTETE, Pr","PRINCIPAL_INVESTIGATOR",{"name":51,"role":49,"phone":20,"phoneExt":20,"email":20},"Claire THIRIEZ, MD",{"name":53,"role":49,"phone":20,"phoneExt":20,"email":20},"Jean-Claude BOUFFETEAU, MD",{"type":55,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[57,59,61],{"name":58,"class":6},"University Hospital, Rouen",{"name":60,"class":6},"University Hospital, Caen",{"name":62,"class":63},"Central Hospital Saint Quentin","OTHER_GOV","100577563",false,"NCT06799923","Possibilities of Use MRI-Guided Laser Interstitial Thermal Therapy in Medically Intractable Tremor","Possibilities of Use Magnetic Resonance Imaging (MRI)-Guided Laser Interstitial Thermal Therapy (LITT) in Treatment of Medically Intractable Tremor","PossibiLITT","Inclusion Criteria:\n\n* Patients 18 years age or older with Parkinson\\'s disease or essential tremor and tremor resistant to medical therapy with a contraindication to deep brain stimulation or refusal deep brain stimulation\n\nExclusion Criteria:\n\n* Contraindication to MRI\n* Contraindication to general anesthesia\n* Patient unable to give their free and informed consent because of cognitive or psychiatric disorders\n* Brain anatomical abnormalities not allowing intervention\n* Adults protected (guardianship, curators) or deprived of liberty.","ALL","18 Years",{"count":74,"type":75},15,"ESTIMATED","INTERVENTIONAL",[78],"NA","Medically intractable tremors are a common difficult clinical situation. Deep brain stimulation decreases Parkinson's disease tremor and essential tremor, but not all patients are candidates from a diagnostic, medical, or social standpoint, prompting the need for alternative surgical strategies. Less invasive lesional brain surgery (thalamotomy) procedures by radio-surgery or MRI-guided focused ultrasound have emerged and have proven to be effective in these third-line indications. Recently, a new technology has emerged allowing the performance of minimally invasive lesion surgeries by MRI-Guided Laser Interstitial Thermal Therapy (MRIg-LITT). MRIg-LITT has been shown to be effective and safe in management of epilepsies and brain tumors. However, no study has evaluated MRIg-LITT for performing thalamotomy in medically intractable tremor.In a pilot study, the investigators propose to evaluate the effect and safety of unilateral thalamotomy by MRIg-LITT in the management of medically intractable tremor of parkinsonian or essential origin.",[81,82,83,84,85],"Laser Interstitial Thermal Therapy","Parkinson Disease","Essential Tremor","Movement Disorders","MRI",[87,82,83,84,85],"laser interstitial thermal therapy","2025-01-28",{"date":90,"type":91},"2025-01-29","ACTUAL",{"date":93,"type":91},"2024-08-01",{"date":95,"type":75},"2026-04",{"name":5,"class":6},1]