[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635644":3},{"organization":4,"outcomesModule":7,"designInfo":22,"detailedDescription":28,"studyPopulation":21,"armGroups":29,"interventions":42,"overallOfficials":21,"centralContacts":51,"locations":57,"responsibleParty":75,"collaborators":21,"id":78,"slug":21,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":21,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":21,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":60,"whyStopped":21,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"University of Roma La Sapienza","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":21},[9,13],{"measure":10,"description":11,"timeFrame":12},"Plaque Index at the Tooth Extraction Site","Assessment of the presence or absence of visible bacterial plaque at the tooth extraction site, recorded as a dichotomous variable (Yes\u002FNo). The absence of plaque indicates better oral hygiene and a lower risk of postoperative infection.","From enrollment to the end of treatment at 15 days",{"measure":14,"description":15,"timeFrame":12},"Gingival Condition of the Peri-Alveolar Tissue","Evaluation of the gingival tissue surrounding the extraction socket based on the presence or absence of clinical signs of inflammation (e.g., redness, edema), recorded as a dichotomous variable (Yes\u002FNo). The absence of inflammation indicates healthier gingival tissue.",[17],{"measure":18,"description":19,"timeFrame":20},"Patient Satisfaction with the Product","Assessment of patient-reported satisfaction with the product using a structured questionnaire administered at the end of the treatment period.\n\nThe questionnaire will evaluate overall acceptability of the product, including:\n\n* taste\n* comfort during application\n* perceived effectiveness\n* preference compared to traditional treatment\n* perceived improvement in sensitivity Each item will be recorded as a dichotomous variable (Yes\u002FNo) (e.g., satisfied vs. not satisfied). Higher frequency of positive responses indicates greater patient satisfaction.","At 15 days post-treatment",null,{"allocation":23,"interventionModel":24,"interventionModelDescription":21,"primaryPurpose":25,"observationalModel":21,"timePerspective":21,"maskingInfo":26},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":27,"maskingDescription":21,"whoMasked":21},"NONE","The study aims to prospectively analyze the clinical action of two different topical agents on post-surgical wounds: a mousse containing biomimetic microparticles (microRepair ABX) and a standard 0.20% chlorhexidine liquid mouthwash. Patients scheduled for extraction due to endodontic or periodontal issues will be randomized into two treatment groups. The protocol includes a baseline assessment (T0) and subsequent clinical evaluations at 24 hours (T1), 7 days (T2), and 15 days (T3). Primary endpoints consist of plaque presence on the surgical wound, gingival texture, and pain levels measured via the Visual Analogue Scale (VAS). Secondary endpoints include swelling (edema), odor, tooth or prosthesis pigmentation, and oral health-related quality of life (OHIP-14). Wound healing progress is objectively quantified using the Clinical Healing Index (CHI), which assesses seven parameters: redness, edema, bleeding, pain on palpation, suppuration, granulation tissue, and the degree of epithelialization. Additionally, the study evaluates patient satisfaction and the \"pleasantness\" of the assigned product, while recording any adverse events or sensitivities during home application.",[30,36],{"label":31,"type":32,"description":33,"interventionNames":34},"Group Test: microRepair ABX Mousse","EXPERIMENTAL","Patients in this group will apply a mouthwash in mousse form enriched with microRepair particles and an Antibacterial Complex (ABX). The product is designed to bind to the oral mucosa, stimulating tissue regeneration and providing antibacterial protection to the post-extraction site.",[35],"Other: microRepair ABX Mousse",{"label":37,"type":38,"description":39,"interventionNames":40},"Group Control: CHX 0.20%","ACTIVE_COMPARATOR","Patients in this group will use a standard liquid mouthwash containing 0.20% Chlorhexidine (CHX). This represents the traditional antiseptic protocol for managing oral hygiene and preventing infection in the post-operative period.",[41],"Other: CHX mouthwash 0.20%",[43,47],{"type":6,"name":44,"description":45,"armGroupLabels":46,"otherNames":21},"microRepair ABX Mousse","Topical application of the mousse on the surgical wound starting from the day after the extraction. The mousse is specifically formulated to promote healing through microparticles that accelerate tissue repair and an antibacterial complex to prevent localized infections.",[31],{"type":6,"name":48,"description":49,"armGroupLabels":50,"otherNames":21},"CHX mouthwash 0.20%","Application of 0.20% Chlorhexidine liquid mouthwash. Used as a control treatment to evaluate the comparative effectiveness of the test product in reducing plaque, pain, and inflammation while promoting socket healing.",[37],[52],{"name":53,"role":54,"phone":55,"phoneExt":21,"email":56},"Fabrizio Guerra","CONTACT","3283150627","fabrizio.guerra@uniroma1.it",[58],{"facility":59,"status":60,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":72},"Sapienza università di Roma","RECRUITING","Roma","RM","00161","Italy","IT",{"type":67,"coordinates":68},"Point",[69,70],11.10642,44.99364,{"lat":70,"lon":69},[73],{"name":53,"role":54,"phone":55,"phoneExt":21,"email":74},"prof.fabrizio.guerra@gmail.com",{"type":76,"investigatorFullName":53,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"PRINCIPAL_INVESTIGATOR","Associate professor, MD, pHd","100635644",false,"NCT07555366","Post-Extraction Healing: microRepair vs Chlorhexidine","Evaluation of Healing in Post-Extraction Sockets Using microRepair Abx Mousse Mouthwash Versus 0.20% Chlorhexidine","Inclusion Criteria:\n\nAge range: Patients between 18 and 75 years of age.\n\nIndication for tooth extraction: Specifically for cases involving:\n\n* Destructive caries that do not allow for conservative or prosthetic recovery.\n* Untreatable endodontic and\u002For periapical lesions.\n* Advanced periodontal lesions with significant loss of supporting tissue.\n* Traumatic lesions involving root fractures (vertical or at the middle third).\n* Malpositioned teeth causing functional alterations.\n* Roots that cannot be prosthetically recovered or residual roots.\n\nExclusion Criteria:\n\nAge: Patients under 18 or over 75 years of age. Systemic Conditions: Presence of immunodepression or immunocompromisation (e.g., HIV infection).\n\nPregnancy and Lactation: Women who are currently pregnant or breastfeeding. Mental Health: Presence of psychiatric disorders. Tobacco Use: Severe smokers, defined as consuming more than 10 cigarettes per day.\n\nSubstance Abuse: History of alcohol or drug abuse.","ALL","18 Years","75 Years",{"count":88,"type":89},30,"ESTIMATED","INTERVENTIONAL",[92],"NA","This randomized clinical trial evaluates the efficacy of a microRepair ABX mouthwash mousse compared to 0.20% chlorhexidine in promoting wound healing following tooth extraction. The study monitors clinical parameters such as pain, swelling, and healing indices at 1, 7, and 15 days post-surgery. The primary objective is to determine if the microRepair ABX technology enhances tissue regeneration and reduces post-operative complications.",[95,96],"Endodontic Issue","Periodontal Issues",[98,99,100],"tooth extraction","abx","chx","2026-04-23",{"date":103,"type":104},"2026-04-29","ACTUAL",{"date":106,"type":104},"2024-09-01",{"date":108,"type":89},"2027-03-01",{"name":5,"class":6},1]