Health Trials

About this trial

Exploring the effect of protective ileostomy compared with transverse colostomy on the occurrence of complications, the occurrence of serious side effects of adjuvant chemotherapy and disease recurrence in patients with low rectal cancer after radical surgery from the perspective of intestinal microecology.

Eligibility criteria

Qualifiers

Pathological confirmed adenocarcinoma of the rectum;

Patients age between 18-80;

Baseline AJCC stage I-III: cT1-4N0-2M0 (AJCC-8 version);

Eastern Cooperative Oncology Group (ECOG) physical status score of 0 to 2;

Disqualifiers

Other types of rectal cancer (adenosquamous carcinoma, squamous carcinoma, neuroendocrine tumors, clear cell carcinoma, spindle cell carcinoma, undifferentiated carcinoma);

Combination of rectal cancer with multiple carcinomas;

Pre-operative presence of acute and chronic infectious diseases or foci of infection;

Intraoperative radical surgery was not performed for various reasons；

Trial design

Treatments tested in this trial

  • Ileostomy
  • Transverse colostomy

Treatment groups

300 Participants
are divided into 2 treatment groups

Locations

1
Fudan University Shanghai Cancer Center200032, Shanghai China

Sponsors and collaborators

Fudan University

Lead sponsor

Source ClinicalTrials.gov