[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100542004":3},{"organization":4,"outcomesModule":7,"designInfo":16,"detailedDescription":11,"studyPopulation":19,"armGroups":20,"interventions":31,"overallOfficials":11,"centralContacts":11,"locations":37,"responsibleParty":57,"collaborators":59,"id":62,"slug":11,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":11,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":11,"enrollmentInfo":71,"targetDuration":11,"studyType":74,"phases":11,"briefSummary":75,"conditions":76,"keywords":11,"overallStatus":40,"whyStopped":11,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"IRCCS SYNLAB SDN","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"To evaluate by analysis of data obtained from NGS techniques whether and which proteins belonging to the Sirtuin family may be deregulated in patients with atherosclerosis or calcific aortic stenosis",null,"36 months",[14],{"measure":15,"description":11,"timeFrame":12},"To evaluate the experimental results achieved in the clinical-diagnostic context",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":17,"timePerspective":18,"maskingInfo":11},"COHORT","PROSPECTIVE","The study plans to recruit 100 patients admitted to AOU Federico II Cardiac Surgery in Naples subject to surgical procedure with atherosclerosis and calcific aortic stenosis with and without diabetes over a 36-month period. Patients without atherosclerosis or aortic valve stenosis will be considered as a control population and where possible included in a statistical design paired for age and sex with the study population",[21,25,28],{"label":22,"type":11,"description":11,"interventionNames":23},"atherosclerosis and calcific aortic stenosis with diabetes patients",[24],"Diagnostic Test: lncRNA signature analyses",{"label":26,"type":11,"description":11,"interventionNames":27},"atherosclerosis and calcific aortic stenosis without diabetes patients",[24],{"label":29,"type":11,"description":11,"interventionNames":30},"Patients without atherosclerosis undergoing surgical procedure for endocarditis",[24],[32],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":11},"DIAGNOSTIC_TEST","lncRNA signature analyses","Specific validation experiments will be performed by Real-Time PCR (C-reactive protein), Western Blot, flow cytometry and microscopy",[29,22,26],[38],{"facility":39,"status":40,"city":41,"state":11,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Irccs Synlab Sdn","RECRUITING","Naples","80143","Italy","IT",{"type":46,"coordinates":47},"Point",[48,49],14.26811,40.85216,{"lat":49,"lon":48},[52],{"name":53,"role":54,"phone":55,"phoneExt":11,"email":56},"Monica Franzese, PhD","CONTACT","+393334041413","direzionescientifica.irccssdn@synlab.it",{"type":58,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[60],{"name":61,"class":6},"Federico II University","100542004",false,"NCT06337227","Potential Role of Sirtuins As Epigenetic Biomarkers of the Patient with Atherosclerosis or Calcific Aortic Stenosis","Potential Role of Sirtuins As Epigenetic Biomarkers for the Clinical Management of the Patient with Atherosclerosis or Calcific Aortic Stenosis","Inclusion Criteria:\n\n* Patients with atherosclerosis or calcific aortic stenosis with and without diabetes older than 18 years of either sex;\n* Patients without atherosclerosis undergoing surgical procedure for endocarditis;\n* Patients who will have signed informed consent\n\nExclusion Criteria:\n\n* Patients for whom biological material cannot be recovered for study purposes;\n* Patients who refuse to participate in the study",true,"ALL","18 Years",{"count":72,"type":73},3,"ESTIMATED","OBSERVATIONAL","The project aims to shed light on the role of Sirtuins, enzymes belonging to the third class of histone deacetylases (class III) involved in epigenetic modifications (deacetylation), focusing mainly on Sirtuin 6 (SIRT6), as a regulator of atherosclerosis and severe aortic valve stenosis through molecular-based and epigenetic studies in human VSMC cells.",[77],"Atherosclerosis and Calcific Aortic Stenosis with and Without Diabetes","2025-03-07",{"date":80,"type":81},"2025-03-11","ACTUAL",{"date":83,"type":81},"2023-10-19",{"date":85,"type":73},"2026-10",{"name":5,"class":6},1]