[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583983":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":69,"collaborators":26,"id":72,"slug":26,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":26,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":26,"enrollmentInfo":80,"targetDuration":26,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Arm","EXPERIMENTAL","Preoperative oral supplementation (immunonutrition)",[13],"Dietary Supplement: Preoperative oral immunonutrition formula",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Arm","ACTIVE_COMPARATOR","Preoperative oral supplementation (polymeric)",[19],"Dietary Supplement: Preoperative oral Isocaloric and isoproteic polymeric formula",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Preoperative oral immunonutrition formula","Intervention arm will daily receive, for 7 days, a preoperative oral formula with immunonutrients: 500 kcal of energy, 41 g of protein, 60 g of carbohydrates, 11 g of lipids, 5.7 g of glutamine, 7 g of arginine, 3.6 g of leucine, 2.7 g of isoleucine, 3.7 g of valine, and 0.35 g of omega 3",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Preoperative oral Isocaloric and isoproteic polymeric formula","Control arm will daily receive, for 7 days, an isocaloric and isoproteic preoperative oral formula: 500 kcal of energy, 41 g of protein, 60 g of carbohydrates, and 11 g of lipids",[15],[32],{"name":33,"affiliation":5,"role":34},"Aurora E Serralde Zúñiga, MD, PhD","PRINCIPAL_INVESTIGATOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":39,"email":40},"CONTACT","+52 5554870900","2193","aurozabeth@yahoo.com.mx",[42],{"facility":33,"status":43,"city":44,"state":45,"zip":46,"country":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","Mexico City","Tlalpan","14080","Mexico",{"type":49,"coordinates":50},"Point",[51,52],-99.12766,19.42847,{"lat":52,"lon":51},[55,56,59,61,63,65,67],{"name":33,"role":37,"phone":38,"phoneExt":39,"email":40},{"name":57,"role":58,"phone":26,"phoneExt":26,"email":26},"José F Estrada Moya, MSc","SUB_INVESTIGATOR",{"name":60,"role":58,"phone":26,"phoneExt":26,"email":26},"Martha Guevara Cruz, MD, PhD",{"name":62,"role":58,"phone":26,"phoneExt":26,"email":26},"Luis E González Salazar, PhD",{"name":64,"role":58,"phone":26,"phoneExt":26,"email":26},"Adriana G Flores López, MSc",{"name":66,"role":58,"phone":26,"phoneExt":26,"email":26},"Omar Vergara Fernández, MD",{"name":68,"role":58,"phone":26,"phoneExt":26,"email":26},"Noel Salgado Nesme, MD",{"type":34,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Aurora Elizabeth Serralde Zúñiga","Principal Investigator","100583983",false,"NCT06883422","Pre-Surgical Immunonutrition's Effect on Colorectal Surgery","Impact of Pre-surgical Oral Immunonutrition on Plasma Levels of Branched-chain Amino Acids in Elective Colorectal Surgery Patients: a Randomized, Double-blind, Controlled, Clinical Trial","Inclusion Criteria:\n\n* Both sexes\n* Over 18 years of age\n* Scheduled for elective colorectal surgery (Resection and intestinal reconnection)\n* Obtaining patient consent\n\nExclusion Criteria:\n\n* Consumption of nutritional supplements during the 2 weeks prior to patient enrollment\n* Consumption of additional nutritional supplements during the 7 days corresponding to the study intervention period\n* Patients diagnosed with chronic kidney disease\n* Patients diagnosed with hepatic cirrhosis\n* Documented allergy to any of the ingredients in the formulas under evaluation (milk and\u002For soy).","ALL","18 Years",{"count":81,"type":82},126,"ESTIMATED","INTERVENTIONAL",[85],"NA","Colorectal surgery patients face excessive catabolism, increasing inflammation and immune compromise. The administration of nutritional supplements known as immunonutrition before gastrointestinal surgery has been shown to improve clinical outcomes; however, the mechanisms underlying these benefits remain inconclusive.\n\nThe objective of the study is to evaluate the effect of preoperative nutritional supplementation with an immunonutrient-enriched formula compared to an isocaloric and isoproteic formula on plasma BCAA concentration in patients undergoing elective colorectal surgery. A double-blind, randomized controlled clinical trial will be conducted. Patients will be required to drink the supplement daily for the 7 days preceding the surgical intervention. Patients in both groups will be instructed to maintain their usual food intake. During the study, there will be two patient assessments and a review of medical records to document the outcomes.",[88],"Colorectal Surgery",[88,90,91,92,93],"Immunonutrition","Enhanced Recovery After Surgery","Preoperative Care","Amino Acids Branched-Chain","2026-03-23",{"date":96,"type":97},"2026-03-27","ACTUAL",{"date":99,"type":97},"2023-05-25",{"date":101,"type":82},"2026-12-31",{"name":5,"class":6},1]