Prospective, observational study to define precipitants and predictors of development of Acute-on-Chronic Liver Failure (ACLF) after surgical interventions, allowing to develop a risk stratification for elective procedures in cirrhotic patients. As well as identifying molecular mechanisms of post-interventional ACLF and thus preparing the ground for development of new therapeutic approaches.
Male or female adult (≥18 years) patient
With or without liver cirrhosis (diagnosed either histologically or by a combination of clinical, laboratory and radiological signs)
Or Non-cirrhotic portal hypertension
Non-pregnant, non-lactating females
Pregnant or lactating females
Patients undergoing surgery as form of palliative cancer therapy
Presence or history of severe extra-hepatic diseases
HIV-positive patients
University Hospital, Bonn
Lead sponsor