[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100406890":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":18,"centralContacts":22,"locations":30,"responsibleParty":49,"collaborators":10,"id":52,"slug":10,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":10,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":70,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"University Hospital, Bonn","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Surgery",null,"Patients with and without liver cirrhosis undergoing surgery.",[13],"Other: No Intervention",[15],{"type":6,"name":16,"description":16,"armGroupLabels":17,"otherNames":10},"No Intervention",[9],[19],{"name":20,"affiliation":5,"role":21},"Michael Praktiknjo, MD","PRINCIPAL_INVESTIGATOR",[23,27],{"name":20,"role":24,"phone":25,"phoneExt":10,"email":26},"CONTACT","+4922828716375","michael.praktiknjo@ukbonn.de",{"name":28,"role":24,"phone":10,"phoneExt":10,"email":29},"Johannes Chang, MD","johannes.chang@ukbonn.de",[31],{"facility":32,"status":33,"city":34,"state":10,"zip":10,"country":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"University Hospital Bonn","RECRUITING","Bonn","Germany",{"type":37,"coordinates":38},"Point",[39,40],7.09549,50.73438,{"lat":40,"lon":39},[43,45,46],{"name":20,"role":24,"phone":44,"phoneExt":10,"email":26},"+49228 28715770",{"name":28,"role":24,"phone":44,"phoneExt":10,"email":29},{"name":47,"role":48,"phone":10,"phoneExt":10,"email":10},"Nina Böhling, MD","SUB_INVESTIGATOR",{"type":21,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Michael Praktiknjo","PI","100406890",false,"NCT04578301","Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease","PERSEVERE","Inclusion Criteria:\n\n* Male or female adult (≥18 years) patient\n* With or without liver cirrhosis (diagnosed either histologically or by a combination of clinical, laboratory and radiological signs)\n* Or Non-cirrhotic portal hypertension\n* Non-pregnant, non-lactating females\n* Ability to understand the patient information and to personally sign and date the informed consent to participate in the study\n* The patient is co-operative and available for the entire study\n* Provided written informed consent\n* Indication for surgical intervention\n\nExclusion Criteria:\n\n* Pregnant or lactating females\n* Patients undergoing surgery as form of palliative cancer therapy\n* Presence or history of severe extra-hepatic diseases\n* HIV-positive patients\n* Previous liver or other transplantation\n* Patients with acute or subacute liver failure without underlying cirrhosis\n* Patients who decline to participate\n* Physician´s denial (e.g. the investigator considers that the patient will not follow the protocol scheduled)","ALL","18 Years",{"count":61,"type":62},200,"ESTIMATED","OBSERVATIONAL","Prospective, observational study to define precipitants and predictors of development of Acute-on-Chronic Liver Failure (ACLF) after surgical interventions, allowing to develop a risk stratification for elective procedures in cirrhotic patients. As well as identifying molecular mechanisms of post-interventional ACLF and thus preparing the ground for development of new therapeutic approaches.",[66,67,9,68,69],"Liver Cirrhosis","Portal Hypertension","Acute-On-Chronic Liver Failure","Non-Cirrhotic Portal Hypertension",[71,68,66,67,9,69],"ACLF","2022-05-17",{"date":74,"type":75},"2022-05-18","ACTUAL",{"date":77,"type":75},"2020-09-22",{"date":79,"type":62},"2026-12-31",{"name":5,"class":6},1]